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Comprehensive analysis of the thyroid undifferentiated conversion by using a mass spectrometry

Research Project

Project/Area Number 22591907
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionKyoto University

Principal Investigator

KITAMURA Morimasa  京都大学, 医学研究科, 助教 (60543262)

Co-Investigator(Kenkyū-buntansha) HIRANO Shigeru  京都大学, 大学院・医学研究科, 講師 (10303827)
TATEYA Ichirou  京都大学, 大学院・医学研究科, 助教 (20526363)
KADA Shinpei  京都大学, 大学院・医学研究科, 医員 (70543263)
Co-Investigator(Renkei-kenkyūsha) SETOU Mitsutoshi  浜松医科大学, 解剖学講座 細胞生物学分野, 教授 (20302664)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords質量顕微鏡 / 甲状腺癌 / 未分化転化 / 甲状腺 / 未分化癌 / ホスファチジルコリン / スフィンゴミエリン
Research Abstract

It was revealed that one type of Sphingomyelin and two types of phosphatidylcholine in thyroid papillary carcinoma are more expressed as compared with normal thyroid tissue by using a mass spectrometry. Sphingomyelin or phosphatidylcholine is a type of phospholipid, and it is classified by each lipid acid constituting each phospholipid.But it is not known whether there is a biological meaningor a characteristic of the cancer due to the differences in fatty acid.Ten types of lipid were expressed in undifferentiated carcinoma more than in normal thyroid tissue. It is generally known that undifferentiated carcinoma has much gene mutation as compared with papillary carcinoma. Therefore each difference in lipid distribution was expected to be large in undifferentiated carcinoma. But in fact the difference in undifferentiated carcinoma was smaller than that in papillarycarcinoma.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (10 results)

All 2012 2011 2010

All Journal Article (4 results) (of which Peer Reviewed: 3 results) Presentation (6 results)

  • [Journal Article] Increased expression of phosphatidylcholine (16:0/18:1) and (16:0/18:2) in thyroid papillary cancer2012

    • Author(s)
      Ishikawa, S., Tateya, I., Hayakawa, T., Masaki, N., Takizawa, Y., Ohno, S., Kojima, T., Kitani, Y., Kitamura, M., Hirano, S., Setou, M., Ito, J
    • Journal Title

      PLoS One

      Volume: 7(11) Issue: 11 Pages: e48873-e48873

    • DOI

      10.1371/journal.pone.0048873

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 頭頸部扁平上皮癌の分子生物学2012

    • Author(s)
      石川征司、楯谷一郎、平野 滋、伊藤壽一
    • Journal Title

      耳鼻咽喉科臨床

      Volume: 105巻 4号 Pages: 393-402

    • NAID

      10030517433

    • Related Report
      2012 Final Research Report
  • [Journal Article] Increased expression of phosphatidylcholine (16:0/18:1) and (16:0/18:2) in thyroid papillary cancer2012

    • Author(s)
      Seiji Ishikawa
    • Journal Title

      PLOSONE

      Volume: 7(11)

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 頭頸部扁平上皮癌の分子生物学2012

    • Author(s)
      石川征司, 楯谷一郎, 平野滋, 伊藤壽一
    • Journal Title

      耳鼻咽喉科臨床

      Volume: 105 Pages: 393-402

    • NAID

      10030517433

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Biomarker profiling of thyroid cancer by imaging mass spectrometry2011

    • Author(s)
      Seiji Ishikawa, Ichiro Tateya, Takahiro Hayasaka, Yoshinori Takizawa, Satoshi Ohno, Tsuyoshi Kojima, Yoshiharu Kitani, Morimasa Kitamura, Shigeru Hirano, Mitsutoshi Setou, Juichi Ito
    • Organizer
      Combined Otolaryngology Spring Meetings.
    • Place of Presentation
      Chicago
    • Related Report
      2012 Final Research Report
  • [Presentation] 質量顕微鏡による甲状腺癌の観察2011

    • Author(s)
      石川征司、楯谷一郎、早坂孝宏、瀧澤義徳、大野 覚、児嶋 剛、木谷芳晴、北村守正、平野 滋、瀬藤光利、伊藤壽一
    • Organizer
      第112回日本耳鼻咽喉科学会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] Biomarker Profiling of Thyroid Cancer by Imaging Mass Spectrometry2011

    • Author(s)
      Ishikawa S
    • Organizer
      American Head & Neck Society 2011 Annual Meeting
    • Place of Presentation
      シカゴ(アメリカ)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 質量顕微鏡による甲状腺癌の観察2010

    • Author(s)
      石川征司、楯谷一郎、大野覚、児嶋剛、木谷芳晴、瀧澤義徳、早坂孝宏、北村守正、平野滋、瀬藤光利、伊藤壽一
    • Organizer
      第43回日本甲状腺外科学会
    • Place of Presentation
      倉敷市・倉敷市民会館
    • Year and Date
      2010-10-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] 質量顕微鏡法による頭頸部腫瘍の解析2010

    • Author(s)
      楯谷一郎、石川征司、大野覚、児嶋剛、木谷芳晴、瀧澤義徳、早坂孝宏、北村守正、平野滋、瀬藤光利、伊藤壽一
    • Organizer
      第111回日本耳鼻咽喉科学会
    • Place of Presentation
      仙台市・仙台国際センター
    • Year and Date
      2010-05-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 質量顕微鏡法による甲状腺癌の観察2010

    • Author(s)
      石川征司、楯谷一郎、平野 滋、北村守正、嘉田真平、伊藤壽一
    • Organizer
      第43回日本甲状腺外科学会
    • Place of Presentation
      倉敷
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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