Comprehensive analysis of the thyroid undifferentiated conversion by using a mass spectrometry
| Project/Area Number |
22591907
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HIRANO Shigeru 京都大学, 大学院・医学研究科, 講師 (10303827)
TATEYA Ichirou 京都大学, 大学院・医学研究科, 助教 (20526363)
KADA Shinpei 京都大学, 大学院・医学研究科, 医員 (70543263)
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| Co-Investigator(Renkei-kenkyūsha) |
SETOU Mitsutoshi 浜松医科大学, 解剖学講座 細胞生物学分野, 教授 (20302664)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 質量顕微鏡 / 甲状腺癌 / 未分化転化 / 甲状腺 / 未分化癌 / ホスファチジルコリン / スフィンゴミエリン |
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| Research Abstract |
It was revealed that one type of Sphingomyelin and two types of phosphatidylcholine in thyroid papillary carcinoma are more expressed as compared with normal thyroid tissue by using a mass spectrometry. Sphingomyelin or phosphatidylcholine is a type of phospholipid, and it is classified by each lipid acid constituting each phospholipid.But it is not known whether there is a biological meaningor a characteristic of the cancer due to the differences in fatty acid.Ten types of lipid were expressed in undifferentiated carcinoma more than in normal thyroid tissue. It is generally known that undifferentiated carcinoma has much gene mutation as compared with papillary carcinoma. Therefore each difference in lipid distribution was expected to be large in undifferentiated carcinoma. But in fact the difference in undifferentiated carcinoma was smaller than that in papillarycarcinoma.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Increased expression of phosphatidylcholine (16:0/18:1) and (16:0/18:2) in thyroid papillary cancer2012
Author(s)
Ishikawa, S., Tateya, I., Hayakawa, T., Masaki, N., Takizawa, Y., Ohno, S., Kojima, T., Kitani, Y., Kitamura, M., Hirano, S., Setou, M., Ito, J
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Journal Title
PLoS One
Volume: 7(11)
Issue: 11
Pages: e48873-e48873
DOI
Related Report
Peer Reviewed
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[Presentation] Biomarker profiling of thyroid cancer by imaging mass spectrometry2011
Author(s)
Seiji Ishikawa, Ichiro Tateya, Takahiro Hayasaka, Yoshinori Takizawa, Satoshi Ohno, Tsuyoshi Kojima, Yoshiharu Kitani, Morimasa Kitamura, Shigeru Hirano, Mitsutoshi Setou, Juichi Ito
Organizer
Combined Otolaryngology Spring Meetings.
Place of Presentation
Chicago
Related Report
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