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Neuromagnetic detection of laryngeal area: Sensory evoked fields to air-puff stimulation

Research Project

Project/Area Number 22591909
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionKyushu University

Principal Investigator

ADACHI Kazuo  九州大学, 大学病院, 助教 (90380386)

Co-Investigator(Kenkyū-buntansha) UMEZAKI Toshiro  九州大学, 大学病院, 講師 (80223600)
SAWATSUBASHI Motohiro  九州大学, 大学病院, 助教 (20315203)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords喉頭粘膜感覚 / 中枢投射 / 脳磁図(MEG) / 再現性 / 脳磁図(MEG) / M60 / M100 / 咽喉頭の知覚 / MEG / 等価電流双極子
Research Abstract

The sensory projections from the oral cavity, pharynx, and larynx are crucial in assuring safe deglutition. Although several studies using neuro-imaging techniques have demonstrated cortical activation related to pharyngeal and laryngeal functions, little is known regarding sensory projections from the laryngeal area to the somatic cortex. The purpose of this study was to establish the cortical activity evoked by somatic air-puff stimulation at the laryngeal mucosa using magnetoencephalography. Twelve healthy volunteers were trained to inhibit swallowing in response to air stimuli delivered to the larynx. Minimum norm estimates was performed on the laryngeal somatosensory evoked fields (LSEFs) to best differentiate the target activations from non-task-related activations. Evoked magnetic fields were recorded with acceptable reproducibility in the left hemisphere, with peak latency of approximately 100 ms in all subjects. Peak activation was estimated at the caudolateral region of the primary somatosensory area (S1). These results establish the ability to detect LSEFs with anacceptable reproducibility within a single subject and among subjects. Therefore, this study suggests a new field for future research on the laryngeal somatic afferent input to the caudolateral region of the S1.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (9 results)

All 2012 2011

All Presentation (9 results)

  • [Presentation] 喉頭粘膜触圧覚刺激時の脳磁場活動2012

    • Author(s)
      宮地英彰、安達一雄、梅崎俊郎、澤津橋基広
    • Organizer
      福岡県地方部会第161回耳鼻咽喉科・頭頸部外科学術講演会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 喉頭粘膜触圧覚刺激時の脳磁場活動2012

    • Author(s)
      宮地英彰、梅崎俊郎、澤津橋基広
    • Organizer
      日本生体磁気学会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation]2012

    • Author(s)
      Hideaki Miyaji, Toshiro Umezaki,Motohiro Sawatsubashi
    • Organizer
      18th International conference on Biomagnetism
    • Place of Presentation
      Paris
    • Related Report
      2012 Final Research Report
  • [Presentation] Neuromagnetic detection of laryngeal area: Sensory evoked fields to air-puff stimulation2012

    • Author(s)
      宮地 英彰
    • Organizer
      18th International Conference on Biomag
    • Place of Presentation
      フランス パリ
    • Related Report
      2012 Annual Research Report
  • [Presentation] 喉頭粘膜触圧覚刺激時の脳磁場活動2012

    • Author(s)
      宮地 英彰
    • Organizer
      第113回日本耳鼻咽喉科学会
    • Place of Presentation
      新潟市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 喉頭粘膜触圧覚刺激時の脳磁場活動2012

    • Author(s)
      宮地 英彰
    • Organizer
      第27回に本生体磁気学会
    • Place of Presentation
      東京都足立区
    • Related Report
      2012 Annual Research Report
  • [Presentation] 咽喉頭知覚刺激時の脳磁場活動2011

    • Author(s)
      宮地英彰
    • Organizer
      第112回日本耳鼻咽喉科学会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2011-05-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] Measurement of laryngopharyngeal sensory evoked magnetic field in the human sensory cortex2011

    • Author(s)
      宮地英彰
    • Organizer
      Dysphagia Research Society 19th Annual Meeting
    • Place of Presentation
      San Antonio, TX
    • Year and Date
      2011-03-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 咽喉頭粘膜感覚刺激時の脳磁場活動2011

    • Author(s)
      宮地英彰、安達一雄、梅崎俊郎、澤津橋基広
    • Organizer
      第112回日本耳鼻咽喉科学会学術講演会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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