Transcutaneous immunization induces antigen specific mucosal and syatemic immune responses in mice
| Project/Area Number |
22591911
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kagoshima University |
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Principal Investigator |
MASEDA Yoshiko 鹿児島大学, 医学部・歯学部附属病院, 助教 (70535666)
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| Co-Investigator(Kenkyū-buntansha) |
KURONO Yuichi 鹿児島大学, 大学院・医歯学総合研究科, 教授 (80153427)
MIYASHITA Keiichi 鹿児島大学, 医学部・歯学部附属病院, 助教 (30585063)
NAGANO Hiromi 鹿児島大学, 大学院・医歯学総合研究科, 助教 (60613148)
MAKISE Takao 鹿児島大学, 医学部・歯学部附属病院, 医員 (30585120)
MATSUNE Shoji 鹿児島大学, 大学院・医歯学総合研究科, 准教授 (00253899)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ホスホリルコリン / コレラトキシン / 経皮免疫 / 経鼻免疫 / 特異的IgA / ﾎｽﾎﾘﾙｺﾘﾝ / ｺﾚﾗﾄｷｼﾝ / 粘膜免疫応答 / ワクチン / 舌下免疫 / 特異的抗体価 / Phoshorylcholine(PC) |
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| Research Abstract |
In order to investigate the differences in the immune responsesamong several mucosal immunizations, mice were immunized with phosphorylcholine (PC) together with cholera toxin (CT) as mucosal adjuvant intranasally and transcutaneously, and the mucosal as well as systemic immune responses were compared. PC-specific IgA antibody titers in saliva and nasal wash were increased by intaranasal as well as transcutaneous immunization to the same levels.
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Report
(4 results)
Research Products
(17 results)
