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Transcutaneous immunization induces antigen specific mucosal and syatemic immune responses in mice

Research Project

Project/Area Number 22591911
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionKagoshima University

Principal Investigator

MASEDA Yoshiko  鹿児島大学, 医学部・歯学部附属病院, 助教 (70535666)

Co-Investigator(Kenkyū-buntansha) KURONO Yuichi  鹿児島大学, 大学院・医歯学総合研究科, 教授 (80153427)
MIYASHITA Keiichi  鹿児島大学, 医学部・歯学部附属病院, 助教 (30585063)
NAGANO Hiromi  鹿児島大学, 大学院・医歯学総合研究科, 助教 (60613148)
MAKISE Takao  鹿児島大学, 医学部・歯学部附属病院, 医員 (30585120)
MATSUNE Shoji  鹿児島大学, 大学院・医歯学総合研究科, 准教授 (00253899)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsホスホリルコリン / コレラトキシン / 経皮免疫 / 経鼻免疫 / 特異的IgA / ホスホリルコリン / コレラトキシン / 粘膜免疫応答 / ワクチン / 舌下免疫 / 特異的抗体価 / Phoshorylcholine(PC)
Research Abstract

In order to investigate the differences in the immune responsesamong several mucosal immunizations, mice were immunized with phosphorylcholine (PC) together with cholera toxin (CT) as mucosal adjuvant intranasally and transcutaneously, and the mucosal as well as systemic immune responses were compared. PC-specific IgA antibody titers in saliva and nasal wash were increased by intaranasal as well as transcutaneous immunization to the same levels.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (17 results)

All 2013 2012 2011

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (15 results)

  • [Journal Article] コレラトキシン経皮免疫による粘膜免疫応答2012

    • Author(s)
      永野広海
    • Journal Title

      日本口腔・咽頭科学会

      Volume: 25(1) Pages: 79-84

    • NAID

      10030552707

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Diversity of mucosal immune responses in upper respiratory airways and the suitability of mucosal vaccines2012

    • Author(s)
      Y. Kurono
    • Journal Title

      Clinical & Experimental Allergy Reviews

      Volume: 12 Pages: 1-6

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] PC 経皮免疫による粘膜免疫応答の誘導2013

    • Author(s)
      永野広海
    • Organizer
      第31回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      倉敷
    • Related Report
      2012 Final Research Report
  • [Presentation] PC経皮免疫による粘膜免疫応答の誘導2013

    • Author(s)
      永野広海
    • Organizer
      第31回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      倉敷市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 可溶性カチオン化ホスホリルコリンによる舌下・経鼻免疫応答の誘導2012

    • Author(s)
      早水佳子
    • Organizer
      第30回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      大津市
    • Year and Date
      2012-02-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] コレラトキシン経皮免疫による粘膜免疫応答の誘導2012

    • Author(s)
      永野広海
    • Organizer
      第30回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      大津市
    • Year and Date
      2012-02-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] PC 経皮免疫による粘膜免疫応答の誘導2012

    • Author(s)
      永野広海
    • Organizer
      第10回日本ワクチン学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] ホスホリルコリンによる経鼻免疫・舌下免疫応答の違いについて2012

    • Author(s)
      間世田佳子
    • Organizer
      第10回日本ワクチン学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Intranasal immunization of with Phosphorylcholine reduced type Iallergic responses in mice. 24thCongrress of the European Rhinologic Society2012

    • Author(s)
      Y. Kurono
    • Organizer
      31th International Symposium of Infection & Allergy of the Nose
    • Place of Presentation
      Toulouse France
    • Related Report
      2012 Final Research Report
  • [Presentation] Transcutaneous immunization with cholera toxin in BALB/C mice.2012

    • Author(s)
      H. Nagano
    • Organizer
      he 14thJapan-Korea Joint Meeting of Otorhinolaryngology-Head and Neck Surgery
    • Place of Presentation
      Kyoto
    • Related Report
      2012 Final Research Report
  • [Presentation] Transcutaneous immunization with cholera toxin in BALB/c mice2012

    • Author(s)
      H.Nagano
    • Organizer
      The 14th Japan-Korea Joint Meeting of Otorhinolaryngology-Head and Neck Surgery
    • Place of Presentation
      Kyoto
    • Related Report
      2012 Annual Research Report
  • [Presentation] Intranasal immunization of with phosphorylcholine reduced type I allergic responses in mice.2012

    • Author(s)
      Y.Kurono
    • Organizer
      24th Congress of the European Rhinologic Society 31th International Symposium of Infection & Allergy of the Nose
    • Place of Presentation
      Toulouse (France)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ホスホリルコリンによる経鼻免疫・舌下免疫応答の違いについて2012

    • Author(s)
      早水佳子
    • Organizer
      第10回日本ワクチン学会
    • Place of Presentation
      横浜市
    • Related Report
      2012 Annual Research Report
  • [Presentation] PC経皮免疫による粘膜免疫応答の誘導2012

    • Author(s)
      永野広海
    • Organizer
      第10回日本ワクチン学会
    • Place of Presentation
      横浜市
    • Related Report
      2012 Annual Research Report
  • [Presentation] コレラトキシン経皮免疫による口腔粘膜免疫応答の誘導2011

    • Author(s)
      永野広海
    • Organizer
      第24回日本口腔・咽頭科学会総会学術講演会
    • Place of Presentation
      広島市
    • Year and Date
      2011-09-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] Phosphorylcholineを用いた経皮免疫について2011

    • Author(s)
      永野広海
    • Organizer
      第26回九州連合地方部会学術講演会
    • Place of Presentation
      久留米市
    • Year and Date
      2011-07-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Immunological difference in upper respiratory tracts between sublingual and intranasal immunization2011

    • Author(s)
      Yoshiko Hayamizu
    • Organizer
      10^<th> International Symposium Recent Advances in Otitis Media
    • Place of Presentation
      New Orleans U.S.A
    • Year and Date
      2011-06-08
    • Related Report
      2011 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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