Impact of TLR triggering on gamma-herpesvirus lytic replication
| Project/Area Number |
22591915
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMANAKA Noboru 和歌山県立医科大学, 医学部, 教授 (10136963)
HOTOMI Muneki 和歌山県立医科大学, 医学部, 准教授 (90336892)
TOGAWA Akihisa 和歌山県立医科大学, 医学部, 講師 (70305762)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | MHV-68 / TLR7 / TLR9 / NF-kB / 融解感染 / ガンマヘルペスウイルス / S11細胞 / リアルタイムPCR / EBV / EB関連悪性リンパ腫 / バーキットリンパ腫 / 溶解感染 / 潜伏感染 / 悪性リンパ腫 / 自然免疫 / TLR |
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| Research Abstract |
Triggering of TLR7 or TLR9 suppresses initiation of MHV-68 lytic replication by the activation of NF-kB, which leads to promotion of gamma-herpes virus latency and lymphomagenesis.
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Report
(4 results)
Research Products
(10 results)
