Gene Therapy for Head and Neck Cancer using Adeno-Associated Virus Vector Harboring Galanin Receptor type1

• Project/Area Number: 22591916
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Jichi Medical University
• Principal Investigator: KANAZAWA Hiromi 自治医科大学, 医学部, 助教 (40570643)
• Co-Investigator(Kenkyū-buntansha): 金澤 丈治 自治医科大学, 医学部, 准教授 (20336374) ; 水上 浩明 自治医科大学, 医学部, 准教授 (20311938)
• Co-Investigator(Renkei-kenkyūsha): 水上 浩明 自治医科大学, 医学部, 准教授 (20311938)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: AAV / GALR1 / 癌抑制遺伝子 / 遺伝子治療 / 頭頸部癌

Research Abstract

The invention of new therapeutic approaches against HNSCC were eagerly anticipated. In this study, we first transduced Head and Neck Cancer cell lines using a recombinant adeno-associated virus serotype 2 (rAAV2)-GFP vector and confirmed a high GFP expres