Study to control metastasis of HNSCC by targeting molecular mechanisms leading to epithelial-mesenchymal transition (EMT)
| Project/Area Number |
22591917
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
FUJII Ryoichi 慶應義塾大学, 医学部, 助教 (30348742)
SHIGETOMI Seiji 慶應義塾大学, 医学部, 助教 (30365366)
HABU Noboru 慶應義塾大学, 医学部, 助教 (60365369)
OOTSUKA Kuninori 慶應義塾大学, 医学部, 助教 (40465026)
SATO Yoichiro 慶應義塾大学, 医学部, 助教 (40624440)
WATANABE Yoshihiro 慶應義塾大学, 医学部, 助教 (30445374)
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| Research Collaborator |
SAKAMOTO Koji 慶應義塾大学, 医学部, 助教 (80338136)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 頭頸部扁平上皮癌 / 転移 / EMT(上皮間葉転換) / 細胞遊走能 / E-cadherin / 転写抑制因子 / Cox2 / 多変量解析 / 頸部リンパ節転移 / EMT（上皮間葉転換） / 生存率 / 独立予後因子 / 細胞遊走運動 / 後発性リンパ節転移 |
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| Research Abstract |
Our study of EMT (epithelial to mesenchymal transition), which is closely involved in a process of cancer metastasis, led to the following results:
1) Downregulation of E-cadherin and overexpression of SIP1 were considered to be predictive of cervical lymph node metastasis of tongue squamous cell carcinoma.
2) Ang2 was shown to enhance metastatic ability of breast cancer cells by promoting cell survival ability via suppression of apoptosis, in addition to induction of EMT.
3) Selective Cox2-inhibition was revealed to include suppression of EMT in its anti-tumor effect.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] Overexpression of SIP1 and downregulation of E-cadherin predict delayed neck metastasis in stage I/II oral tongue squamous cell carcinoma after partial glossectomy2012
Author(s)
Sakamoto K, Imanishi Y, To mi ta T, Shimoda M, Kameyama K, Shibata K, Sakai N, Ozawa H, Shigetomi S, Fujii R, Fujii M, Ogawa K
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Journal Title
Ann Surg Oncol.
Volume: 19
Issue: 2
Pages: 612-9
DOI
Related Report
Peer Reviewed
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[Journal Article] 舌扁平上皮癌症例の臨床統計学的検討2011
Author(s)
坂本耕二,今西順久,冨田俊樹,小澤宏之,田川崇正,藤井良一,重冨征爾,羽生 昇,大塚邦憲,山下拓,菅家稔,藤井正人,小川郁
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Journal Title
頭頸部癌
Volume: 37
Pages: 529-535
NAID
Related Report
Peer Reviewed
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[Presentation] Stage I/II舌癌部分切除後の後発頸部リンパ節転移予測におけるSIP1発現亢進とE-cadherin発現減弱の役割2012
Author(s)
坂本耕二,今西順久,冨田俊樹,下田将之,亀山香織,柴田克志,酒井伸也,小澤宏之,藤井良一,重冨征爾,藤井正人,小川 郁
Organizer
慶應東大ジョイントカンファレンス
Place of Presentation
東京
Year and Date
2012-02-02
Related Report
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[Presentation] StageI/II舌癌部分切除後の後発頸部リンパ節転移予測におけるEMT関連因子の役割2011
Author(s)
坂本耕二,今西順久,冨田俊樹,下田将之,亀山香織,柴田克志,酒井伸也,小澤宏之,藤井良一,重冨征爾,藤井正人,小川 郁
Organizer
第8回頭頸部腫瘍セミナー
Place of Presentation
東京
Year and Date
2011-11-25
Related Report
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[Presentation] Overexpression of SIP1 and down-regulation of E-cadherin predict delayed neck metastasis in stage I/II oral tongue squamous cell carcinoma after partial glossectomy.2011
Author(s)
Sakamoto K, Imanishi Y, Shimoda M, Kameyama K, Tomita T, Ozawa H, Tagawa, T, Shibata K, Sakai N, and Ogawa K
Organizer
AACR 102^<nd>Annual Meeting
Place of Presentation
Orlando/FA, USA
Related Report
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[Presentation] Overexpression of SIP1 and down-regulation of E-cadherin predict delayed neck metastasis in stage I/II OSCC2010
Author(s)
Sakamoto K, Imanishi Y, Shimoda M, Kameyama K, Tomita T, Ozawa H, Tagawa, T, Shibata K, Sakai N, and Ogawa K.
Organizer
AHNS 2010 Research Workshop
Place of Presentation
Arlington/VA, USA
Related Report
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