Novel therapeutic concept against head and neck cancer using disease-specific microRNAs.

• Project/Area Number: 22591918
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Keio University
• Principal Investigator: SAITO Koichiro 慶應義塾大学, 医学部, 講師 (40296679)
• Co-Investigator(Kenkyū-buntansha): ZAMA Takeru 慶應義塾大学, 医学部, 特任講師 (30296719)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 喉頭科学 / 頭頸部腫瘍 / 癌 / マイクロRNA / 治療 / 診断 / 遺伝子 / マイクロＲＮＡ / 核酸 / トランスレーショナルリサーチ

Research Abstract

In this study, we have successfully identified laryngeal cancer-specific microRNAs (miRNAs) using clinical tissue samples. While several miRNAs were over-expressed in cancers, expressions of several miRNAs were suppressed in diseased tissues. Growth level

Research Products

• [Journal Article] 頭頸部扁平上皮癌の最新情報 頭頸部扁平上皮癌に対する新しい診断法 頭頸部扁平上皮癌の腫瘍マーカー (2012)
  • Author(s): 齋藤康一郎, 座間猛
  • Journal Title: JOHNS Volume: 28 Pages: 1170-1174
• [Journal Article] 【頭頸部扁平上皮癌の最新情報】 頭頸部扁平上皮癌に対する新しい診断法 頭頸部扁平上皮癌の腫瘍マーカー (2012)
  • Author(s): 齋藤康一郎
  • Journal Title: JOHNS Volume: 28 Pages: 1170-1174
• [Presentation] シンポジウム「新しい頭頸部癌治療の展望」miRNA医薬 (2011)
  • Author(s): 齋藤康一郎、座間猛
  • Organizer: 第35回日本頭頸部癌学会
  • Place of Presentation: 愛知
  • Year and Date: 2011-06-09
• [Presentation] シンポジウム「新しい頭頸部癌治療の展望」miRNA医薬 (2011)
  • Author(s): 齋藤康一郎、座間猛
  • Organizer: 第35回日本頭頸部癌学会
  • Place of Presentation: ウインクあいち(愛知県)(招待講演)
  • Year and Date: 2011-06-09
• [Presentation] Regulation of cancer-specific microRNA by aberrant DNA methylation in laryngeal cancer. (2011)
  • Author(s): Yabe H, Saito K, Zama T, et al
  • Organizer: 102^<nd>Annual Meeting of American Association for Cancer Research
  • Place of Presentation: Orlando, FL, USA
  • Year and Date: 2011-04-05
• [Presentation] Regulation of cancer-specific microRNA by aberrant DNA methylation in laryngeal cancer (2011)
  • Author(s): Yabe H, Saito K, Zama T, et al
  • Organizer: 102^<nd> Annual Meeting of American Association for Cancer Research
  • Place of Presentation: Orlando, FL, USA
  • Year and Date: 2011-04-05
• [Presentation] The laryngeal cancer specific small RNAome revealed by deep sequencing using Applied Biosystems SOLiD platform. (2011)
  • Author(s): Saito K, Zama T, et al
  • Organizer: 102^<nd>Annual Meeting of American Association for Cancer Research
  • Place of Presentation: Orlando, FL, USA
  • Year and Date: 2011-04-04
• [Presentation] The laryngeal cancer specific small RNAome revealed by deep sequencing using Applied Biosystems SOLiD platform (2011)
  • Author(s): Saito K, Zama T, et al
  • Organizer: 102^<nd> Annual Meeting of American Association for Cancer Research
  • Place of Presentation: Orlando, FL, USA
  • Year and Date: 2011-04-04
• [Presentation] 頭頸部癌および婦人科癌における疾患特異的miRNAsとDNAメチル化異常 (2010)
  • Author(s): 齋藤康一郎、座間猛 他
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-08
• [Presentation] 頭頸部癌の新規診断治療標的としての疾患特異的マイクロRNA (2010)
  • Author(s): 矢部はる奈、齋藤康一郎、座間猛 他
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-08
• [Presentation] 頭頸部癌および婦人科癌における疾患特異的miRNAsとDNAメチル化異常(Comparative analysis between cancer-specific miRNAs and aberrant DNA methylation in head and neck cancer or gynecological cancer) (2010)
  • Author(s): 齋藤康一郎、座間猛, ら
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-08
• [Presentation] 頭頸部癌の新規診断治療標的としての疾患特異的マイクロRNA(Disease-specific miRNAs as novel diagnostic biomarker and therapeutic target for head and neck cancer) (2010)
  • Author(s): 矢部はる奈、齋藤康一郎、座間猛, ら
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-08
• [Presentation] 疾患特異的マイクロRNAを標的とした下咽頭癌の新規治療 (2010)
  • Author(s): 宇野光祐、齋藤康一郎、座間猛 他
  • Organizer: 第69回日本癌学会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-23
• [Presentation] 喉頭癌および子宮体癌における癌特異的miRNAsならびにDNAメチル化異常 (2010)
  • Author(s): 木村美和子、齋藤康一郎、座間猛 他
  • Organizer: 第69回日本癌学会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-23
• [Presentation] 疾患特異的マイクロRNAを標的とした下咽頭癌の新規治療(Disease specific miRNAs as novel therapeutic target for hypopharyngeal cancer) (2010)
  • Author(s): 宇野光祐、齋藤康一郎、座間猛, ら
  • Organizer: 第69回日本癌学会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-23
• [Presentation] 喉頭癌および子宮体癌における癌特異的miRNAsならびにDNAメチル化異常(Comparative analysis of cancer-specific miRNAs and aberrant DNA methylation in laryngeal cancer or endometrial cancer) (2010)
  • Author(s): 木村美和子、齋藤康一郎、座間猛, ら
  • Organizer: 第69回日本癌学会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-23
• [Presentation] 喉頭癌の新規診断マーカー・治療標的としてのmiR-196a (2010)
  • Author(s): 齋藤康一郎、座間猛 他
  • Organizer: 第69回日本癌学会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-22
• [Presentation] 喉頭癌の新規診断マーカー・治療標的としてのmiR-196a(miR-196a is a novel diagnostic biomarker and therapeutic target for laryngeal cancer) (2010)
  • Author(s): 齋藤康一郎、座間猛, ら
  • Organizer: 第69回日本癌学会 English Workshops
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-22
• [Presentation] miR-196a is a novel diagnostic biomarker and therapeutic target for laryngeal cancer. (2010)
  • Author(s): Saito K, Zama T, et al
  • Organizer: 101^<st>Annual Meeting of American Association for Cancer Research
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2010-04-20
• [Presentation] miR-196a is a novel diagnostic biomarker and therapeutic target for laryngeal cancer. (2010)
  • Author(s): Saito K, Zama T, et al.
  • Organizer: Annual Meeting of American Association for Cancer Research
  • Place of Presentation: Washington DC
  • Year and Date: 2010-04-20
• [Remarks]
  • URL: http://www.keio-ent.jp/
• [Remarks] 慶應義塾大学医学部 耳鼻咽喉科学教室
• [Remarks] 慶應義塾大学医学部 耳鼻咽喉科学教室
  • URL: http://www.keio-ent.jp/
• [Remarks]
  • URL: http://www.keio-ent.jp/
• [Remarks]
  • URL: http://www.keio-ent.jp/
• [Patent(Industrial Property Rights)] バイオマーカーとしての新規スモールRNAを用いた腫瘍の診断 (2011)
  • Inventor(s): 座間猛、齋藤康一郎、神本高宏
  • Industrial Property Rights Holder: 座間猛、齋藤康一郎、神本高宏
  • Filing Date: 2011-05-18
• [Patent(Industrial Property Rights)] バイオマーカーとしての新規スモールRNAを用いた腫瘍の診断 (2011)
  • Inventor(s): 座間猛, 齋藤康一郎, 神本高宏
  • Industrial Property Rights Holder: 座間猛, 齋藤康一郎, 神本高宏
  • Industrial Property Number: 2011-111206
  • Filing Date: 2011-05-18
• [Patent(Industrial Property Rights)] バイオマーカーとしてのマイクロRNAを用いた婦人科がんの診断・治療選択(Diagnosis/Therapeutic Strategy For Gynecological Cancer By Utilizing Micro-RNA as Biomarker) (2010)
  • Inventor(s): 座間猛、平沢晃、齋藤康一郎、赤羽智子
  • Industrial Property Rights Holder: 学校法人 慶應義塾
  • Filing Date: 2010-12-15
  • Overseas
• [Patent(Industrial Property Rights)] バイオマーカーとしてのマイクロRNAを用いた頭頸部腫瘍の診断・治療選択(Diagnosis/Treatment Option for Head-And-Neck Tumor Using Micro-RNA as Biomarker) (2010)
  • Inventor(s): 座間猛、齋藤康一郎、平沢晃、長西秀樹
  • Industrial Property Rights Holder: 学校法人 慶應義塾
  • Filing Date: 2010-12-06
  • Overseas
• [Patent(Industrial Property Rights)] バイオマーカーとしてのマイクロRNAを用いた頭頸部腫瘍の診断・治療選択 (Diagnosis/Treatment Option for Head-And-Neck Tumor Using Micro-RNA as Biomarker) (2010)
  • Inventor(s): 座間猛, 齋藤康一郎, 平沢晃, 長西秀樹
  • Industrial Property Rights Holder: 学校法人慶應義塾
  • Filing Date: 2010-12-06
  • Overseas
• [Patent(Industrial Property Rights)] バイオマーカーとしてのマイクロRNAを用いた婦人科がんの診断・治療選択(Diagnosis/Therapeutic Strategy For Gynecological Cancer By Utilizing Micro-RNA as Biomarker) (2010)
  • Inventor(s): 座間猛, 平沢晃, 齋藤康一郎, 赤羽智子
  • Industrial Property Rights Holder: 学校法人慶應義塾
  • Filing Date: 2010-12-15
  • Overseas