| Project/Area Number |
22591919
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|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
|
|---|
| Research Institution | Juntendo University |
|---|
Principal Investigator |
YOKOI Naoko 順天堂大学, 医学部, 准教授 (60306975)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
YOKOI Hidenori 杏林大学, 医学部, 准教授 (80317487)
池田 勝久 順天堂大学, 医学部, 教授 (70159614)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | 扁桃 / Siglec-2 / Siglec-6 / シグレック-2 / シグレック-6 / 扁桃慢性炎症疾患 / 扁桃炎 / 抑制性レセプター |
|---|
| Research Abstract |
Siglec-2 is expressed in large amounts in B-cell areas of the lymphoid follicles in the tonsils, and its expression is particularly strong in the mantle zone, which is the area of accumulation of relatively small lymphocytes similar to those found in the epithelial side. Further, Siglec-6 has been shown to be expressed in the mast cells in the connective tissue and T -cell areas, namely, in the interfollicular region; however, the expression levels differed depending on the sample. The expression levels of Siglec-2 and Siglec-6 in mast cells and B cells in focal tonsillitis, chronic tonsillitis, and tonsillar hypertrophy were analyzed and compared, but no apparent significant difference was found.
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