Elucidation of the molecular mechanism of the tonsillitis by new inhibitory receptor Siglec-2 and -6
| Project/Area Number |
22591919
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Juntendo University |
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Principal Investigator |
YOKOI Naoko 順天堂大学, 医学部, 准教授 (60306975)
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| Co-Investigator(Kenkyū-buntansha) |
YOKOI Hidenori 杏林大学, 医学部, 准教授 (80317487)
池田 勝久 順天堂大学, 医学部, 教授 (70159614)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 扁桃 / Siglec-2 / Siglec-6 / シグレック-2 / シグレック-6 / 扁桃慢性炎症疾患 / 扁桃炎 / 抑制性レセプター |
|---|
| Research Abstract |
Siglec-2 is expressed in large amounts in B-cell areas of the lymphoid follicles in the tonsils, and its expression is particularly strong in the mantle zone, which is the area of accumulation of relatively small lymphocytes similar to those found in the epithelial side. Further, Siglec-6 has been shown to be expressed in the mast cells in the connective tissue and T -cell areas, namely, in the interfollicular region; however, the expression levels differed depending on the sample. The expression levels of Siglec-2 and Siglec-6 in mast cells and B cells in focal tonsillitis, chronic tonsillitis, and tonsillar hypertrophy were analyzed and compared, but no apparent significant difference was found.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Overexpression of TEX101, a potential novel cancer marker, in head and neck squamous cell carcinoma2012
Author(s)
Yoshitake H, Yokoi H, Ishikawa H, Maruyama M, Endo S, Nojima M, Yoshida K, Yoshikawa H, Suzuki F, Takamori K, Fujiwara H, Araki Y.
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Journal Title
Cancer Biomark
Volume: 12(3)
Pages: 141-8
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[Journal Article] Antimicrobial peptides human beta-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cells2010
Author(s)
Niyonsaba F, Ushio H, Hara M, Yokoi H, Tominaga M, Takamori K, Kajiwara N, Saito H, Nagaoka I, Ogawa H, Okumura K
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Journal Title
J Immunol
Volume: 184
Pages: 3526-34
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[Journal Article] Lipo-PGE1の突発性難聴に対する有効性2010
Author(s)
飯塚崇, 笠井美里, 春山琢男, 峯川明, 齊藤達矢, 林千江里, 八尾亨, 酒井陽子, 一針幸子, 横井尚子, 横井秀格, 古川正幸, 関眞規子, 楠威志, 池田勝久
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Journal Title
耳鼻咽喉科臨床補冊
Volume: 126
Pages: 10-14
NAID
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