Molecular mechanisms of the onset of chronic tonsillitis induced by new type of cytokine, IL-17 Development of hearing aid applied to the ear drum directly driven by vibration
| Project/Area Number |
22591921
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAMIYA Kazusaku 順天堂大学, 医学部, 講師 (10374159)
KUSUNOKI Takesi 順天堂大学, 医学部, 准教授 (30248025)
IKEDA Katsuhisa 順天堂大学, 医学部, 教授 (70159614)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 口腔咽頭科学 / 扁桃炎 / Tリンパ球 / IL-17 / 扁桃濾胞 / 抗原提示細胞 / 扁桃腺 |
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| Research Abstract |
We demonstrated the relevance of IL-17 to chronic tonsillitis, tonsillar hypertrophy, and focus infection. The expression of IL-17 protein was investigated by FACS and Western blotting using tonsillar lymphocytes and peripheral blood lymphocytes. The localization and expression of IL-17 was differed among several disorders. The B cells inside tonsillar tissues stimulated by pokeweed mitogen resulted in a significant contribution to production of IL-17 antibodies.
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Report
(4 results)
Research Products
(2 results)
