Molecular mechanisms of the onset of chronic tonsillitis induced by new type of cytokine, IL-17 Development of hearing aid applied to the ear drum directly driven by vibration

• Project/Area Number: 22591921
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Juntendo University
• Principal Investigator: ICHIHARI Yukiko 順天堂大学, 医学部, 准教授 (30327803)
• Co-Investigator(Kenkyū-buntansha): KAMIYA Kazusaku 順天堂大学, 医学部, 講師 (10374159) ; KUSUNOKI Takesi 順天堂大学, 医学部, 准教授 (30248025) ; IKEDA Katsuhisa 順天堂大学, 医学部, 教授 (70159614)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 口腔咽頭科学 / 扁桃炎 / Tリンパ球 / IL-17 / 扁桃濾胞 / 抗原提示細胞 / 扁桃腺

Research Abstract

We demonstrated the relevance of IL-17 to chronic tonsillitis, tonsillar hypertrophy, and focus infection. The expression of IL-17 protein was investigated by FACS and Western blotting using tonsillar lymphocytes and peripheral blood lymphocytes. The localization and expression of IL-17 was differed among several disorders. The B cells inside tonsillar tissues stimulated by pokeweed mitogen resulted in a significant contribution to production of IL-17 antibodies.

Research Products

• [Journal Article] Tonsillar TLR9 expression and efficacy of tonsillectomy with steroid pulse therapy in IgA nephropathy patients (2012)
  • Author(s): Sato D, Suzuki Y, Kano T, Suzuki H, Matsuoka J, Yokoi H, Horikoshi S, Ikeda K, Tomino Y.
  • Journal Title: Nephrol Dial Transplant Volume: 27(3) Pages: 1090-7
  • Peer Reviewed
• [Journal Article] Tonsillar TLR9 expression and efficacy of tonsillectomy with steroid pulse therapy in IgA nephropathy patients. (2012)
  • Author(s): Sato D
  • Journal Title: Nephrol Dial Transplant. Volume: 27(3) Pages: 1090-7
  • Peer Reviewed