Investigation of prostaglandins receptors and their clinicalsignificance in head and neck squamous cell carcinoma

Research Project

Project/Area Number	22591923
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Otorhinolaryngology
Research Institution	Osaka Medical College
Principal Investigator	KAWATA Ryo 大阪医科大学, 医学部, 教授 (40224787)
Co-Investigator(Kenkyū-buntansha)	LEE Kotetsu 大阪医科大学, 医学部, 講師 (10368087)
Project Period (FY)	2010 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	プロスタグランジン / シクロキシゲナーゼ / 頭頸部扁平上皮癌 / PGE 合成酵素PGE 受容体 / 転移 / 組織学的分化度 / PGE合成酵素 / PGE受容体
Research Abstract	Overexpression of both cyclooxygenase (COX) -2 and mPGES-1 were evaluated by immunohistochemistry in head and neck squamous cell carcinoma. Localization of COX-2 and mPGES-1 was very similar, and well-differentiated tumors showed stronger expression than poorly differentiated tumors. The COX-2 and mPGES-1 mRNA were significantly higher in well-differentiated carcinomas and N0 patients.Receptors of PGE2, EP1 to EP4 were all expressed in carcinoma cells, especially in EP2.