Vascular adhesion protein-1 as a prognostic factor in orbital tumor

• Project/Area Number: 22591926
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Hokkaido University
• Principal Investigator: NODA Mika 北海道大学, 北海道大学病院, 助教 (10296668)
• Co-Investigator(Kenkyū-buntansha): KASE Satoru 北海道大学, 大学院・医学研究科, 客員研究員 (60374394) ; NODA Kousuke 北海道大学, 大学院・医学研究科, 講師 (90296666)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 眼窩腫瘍 / 白血球接着分子 / VAP-1

Research Abstract

Conjunctival tumors are one of the most common tumors in the ocular adnexa, in which pyogenic granuloma and extranodal marginal zone B-cell lymphoma (EMZL) are benign and malignant tumors involved with inflammatory cells, respectively. However, little is known about the contribution of inflammation underlying the pathogenesis of pyogenic granuloma and EMZL. We analyzed the expression and immunolocalization of vascular adhesion protein (VAP)-1 in the tumors. Conjunctival tumors including pyogenic granuloma and EMZL, and 2 normal conjunctivas were analyzed by immunohistochemistry for VAP-1 and CD31 expression. Immunoreactivity for VAP-1 was detected in the lumen of microvessels in pyogenic granuloma and in EMZLs. In contrast, normal bulbar conjunctival tissues demonstrated weak cytoplasmic immunoreactivity for VAP-1 in the blood vessels. In sum, the immunolocalization of VAP-1 varied in the histopathology of the conjunctiva, involving the pathology of inflammatory conjunctival disorders.

Research Products

• [Journal Article] Immunolocalization of vascular adhesion protein-1 in human conjunctival tumors (2012)
  • Author(s): Fukuhara J, Kase S, Noda K, Kanda A, Murata M, Noda M, Ando R, Dong Z, Ishida S
  • Journal Title: Ophthalmic Res Volume: 48 Issue: 1 Pages: 33-37
  • DOI: 10.1159/000335983
  • Peer Reviewed
• [Journal Article] Blockade of vascular adhesion protein-1 attenuates choroidal neovasculari--zation (2012)
  • Author(s): Yoshikawa N, Noda K, Ozawa Y, Tsubota K, Mashima Y, Ishida S
  • Journal Title: Mol Vis. Volume: 18 Pages: 593-600
  • Peer Reviewed
• [Journal Article] Soluble vascular adhesion protein-1 accumulates in prolifera--tive diabetic retinopathy (2012)
  • Author(s): Murata M, Noda K, Fukuhara J, Kanda A, Kase S, Saito W, Ozawa Y, Mochizuki S, Kimura S, Mashima Y, Okada Y, Ishida S
  • Journal Title: InvestOphthalmol Vis Sci Volume: 53 Pages: 4055-4062
  • Peer Reviewed
• [Journal Article] Blockade of vascular adhesion protein-1 attenuates choroidal neovascularization (2012)
  • Author(s): Yoshikawa N, Noda K, Ozawa Y, Tsubota K, Mashima Y, Ishida S
  • Journal Title: Molecular Vision Volume: 18 Pages: 593-600
  • NAID: 120005372295
  • Peer Reviewed
• [Journal Article] Soluble vascular adhesion protein-1 accumulates in proliferative diabetic retinopathy (2012)
  • Author(s): Murata M, Noda K, Fukuhara J, Kanda A, Kase S, Saito W, Ozawa Y, Mochizuki S, Kimura S, Mashima Y, Okada Y, Ishida S
  • Journal Title: Investigative Ophthalmology & Visual Science Volume: 53 Pages: 4055-4062
  • Peer Reviewed
• [Journal Article] Extranodal marginal zone B-cell lymphoma involving superior rectus muscle: A clinicopathological case report (2011)
  • Author(s): Fukuhara J, Kase S, Noda M, Ishijima K, Ishida S
  • Journal Title: Oncol Lett Volume: 2 Pages: 489-491
  • NAID: 120005372297
  • Peer Reviewed
• [Journal Article] Conjunctival lymphopr--oliferative disorder (2011)
  • Author(s): Fukuhara J, Kase S, Ishijima K, NodaM, Ishida S
  • Journal Title: Ophthalmology Volume: 118 Issue: 2 Pages: 423-423
  • DOI: 10.1016/j.ophtha.2010.08.031
  • Peer Reviewed
• [Journal Article] Extranodal marginal zone B-cell lymphoma involving superior rectus muscle (2011)
  • Author(s): Fukuhara J, Kase S, Noda M, Ishijima K, Ishida S.
  • Journal Title: Oncol Letter Volume: 2 Pages: 489-491
  • Peer Reviewed
• [Presentation] Expression of vascular endothelial growth factor in human conjunctival lymphoma (2012)
  • Author(s): Kinoshita S, Kase S, Fukuhara J, Dong, Ando R, Lennikov A, Kanda A, Noda K, Ishida S
  • Organizer: ARVO (Association for Research in Vision and Ophthalmology)Annual Meeting
  • Place of Presentation: Broward County convention Center(USA)
• [Presentation] Impact of intravitreal bevacizumab on accumulation of vascular adhesion protein-1 in proliferativediabetic retinopathy (2012)
  • Author(s): Ando R, Noda K, Murata M, Namba S, Kinoshita S, Fukuhara J, Dong Z, Saito W, Kanda A, Ishida S
  • Organizer: ARVO (Association for Research in Vision and Ophthalmology)Annual Meeting
  • Place of Presentation: Broward County convention Center(USA)
• [Presentation] Expression of vascular endothelial growth factor in human conjunctival lymphoma (2012)
  • Author(s): Kinoshita S, Kase S, Fukuhara J, Dong, Ando R, Lennikov A, Kanda A, Noda K, Ishida S.
  • Organizer: ARVO (Association for Research in Vision and Ophthalmology) Annual Meeting
  • Place of Presentation: Broward County convention Center（USA）
• [Presentation] Impact of intravitreal bevacizumab on accumulation of vascular adhesion protein-1 in proliferative diabetic retinopathy (2012)
  • Author(s): Ando R, Noda K, Murata M, Namba S, Kinoshita S, Fukuhara J, Dong Z, Saito W, Kanda A, Ishida S
  • Organizer: ARVO (Association for Research in Vision and Ophthalmology) Annual Meeting
  • Place of Presentation: Broward County convention Center（USA）