| Project/Area Number |
22591927
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Hokkaido University |
|---|
Principal Investigator |
NANBA Kenichi 北海道大学, 北海道大学病院, 講師 (70333599)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NISHIMURA Shinichirou 北海道大学, 先端生命科学研究院, 教授 (00183898)
KITAICHI Nobuyoshi 北海道大学, 大学院・医学研究科, 客員准教授 (40431366)
AMANO Maho 北海道大学, 先端生命科学研究科(研究院), 特任助教 (80365808)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | グライコミクス / ぶどう膜炎 / 糖鎖 / グライコプロッティング / EAU / 実験的自己免疫性ぶどう膜網膜炎 / ベーチェット病 / グライコブロッティング |
|---|
| Research Abstract |
Glycoblottoing which was newly developed carbohydrate structural analysis was performed in uveitis patients. In the serum of uveitis patients, total amount of carbohydrate was increased in uveitis patients, and 3 carbohydrate chains that amount were changed in the active stage were found. In Behcet’s disease, carbohydrate chains that were associated with HLA-B51 or exraocular manifestations were found, however carbohydrate chains that were associated with ocular inflammatory attacks were not found. In mouse model experimental autoimmune uveoretinitis, carbohydrate chains that were changed with immunization were found, but they were not specific changes associated with induced uveitis.
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