Identification for glaucoma related genes and application for diagnosis and pharmacogenomics
| Project/Area Number |
22591928
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Tohoku University |
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Principal Investigator |
FUSE Nobuo 東北大学, 東北メディカル・メガバンク機構, 教授 (10302134)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 遺伝学 / 遺伝子 / ゲノム / 臨床 |
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| Research Abstract |
We have done the screening for the glaucoma genes using the single nucleotide polymorphisms (SNPs). Using association study, we identified the glaucoma susceptibility genes for primary open angle glaucoma, normal tension glaucoma, and exfoliation glaucoma. We also detect the rare amino acid substitutions in glutamate transporter gene GLAST by candidate gene approach. By the association study using SNPs and candidate gene approach, we detected glaucoma susceptibility genes.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Association of HK2and NCK2 with Normal Tension Glaucoma in the Japanese Population2013
Author(s)
Shi D, Funayama T, Mashima Y, Takano Y,Shimizu A, YamamotoK, Mengkegale M, Miyazawa A, Yasuda N, Fukuchi T, Abe H, Ideta H, Nishida K, Nakazawa T, Richards JE, Fuse N.
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Journal Title
PLoS ONE
Volume: 8; e54115
Pages: 1-11
Related Report
Peer Reviewed
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[Journal Article] Association of Toll-like receptor 4 gene polymorphisms in Japanese subjects with primary open angle, normal tension, and exfoliation glaucoma2012
Author(s)
Takano Y, Shi D, Shimizu A, Funayama T, Mashima Y, Yasuda N, Fukuchi T, Abe H, Ideta H, Zheng X, Shiraishi A, Ohashi Y, Nishida K, Nakazawa T, Fuse N.
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Journal Title
Am J Ophthalmol
Volume: 154
Issue: 5
Pages: 825-832
DOI
Related Report
Peer Reviewed
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[Presentation] 遺伝と診断2012
Author(s)
布施昇男
Organizer
第23回緑内障学会シンポジウム小児緑内障
Place of Presentation
金沢
Year and Date
2012-09-28
Related Report
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