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Promyelocytic leukemia tumor suppressor as therapeutic agent for diabetic retinopathy

Research Project

Project/Area Number 22591929
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionThe University of Tokushima

Principal Investigator

MITAMURA Yoshinori  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (30287536)

Co-Investigator(Kenkyū-buntansha) NAGASAWA Toshihiko  徳島大学, 病院, 助教 (00511338)
KATOME Takashi  徳島大学, 病院, 助教 (50464342)
Co-Investigator(Renkei-kenkyūsha) HARADA Takayuki  公益財団法人東京都医学総合研究所, 視覚 病態プロジェクト, 副参事研究員 (90345306)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords外科 / 細胞・組織 / 生体分子 / 糖尿病 / 臨床
Research Abstract

Promyelocytic leukemia tumor suppressor (PML) mRNA expression levels in membrane samples, and the PML protein concentrations in aqueous humor and vitreous fluid samples were significantly lower in PDR patientsthan control patients. We observed a statistically significant inverse correlation between the concentrations of PML and vascular endothelial growth factor in the aqueous humor and vitreous fluid of PDR patients. Taken together, PML may be a good candidate as a diagnostic marker and a therapeutic agent for PDR.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (11 results)

All 2013 2012 2011 2010

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (2 results)

  • [Journal Article] Inhibition of ASK1-p38 pathway prevents neural cell death following optic nerve injury.2013

    • Author(s)
      Katome, T., Namekata, K., Guo, X., Semba, K., Kittaka, D., Kawamura, K., Kimura, A., Harada, C., Ichijo, H., Mitamura, Y. and Harada, T.
    • Journal Title

      Cell Death Differ.

      Volume: 20 Issue: 2 Pages: 270-280

    • DOI

      10.1038/cdd.2012.122

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Photoreceptor impairment and restoration on optical coherence tomographic image.2013

    • Author(s)
      Mitamura Y, et al.
    • Journal Title

      J Ophthalmol

      Volume: Volume 2013 Pages: 1-7

    • DOI

      10.1155/2013/518170

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of promyelocytic leukemia protein and vascular endothelial growth factor in aqueous humor and vitreous fluid in patients with proliferative diabetic retinopathy2012

    • Author(s)
      Katome T、Namekata 、Naito T、Semba K、Guo X、Harada C、Harada T、Mitamura Y
    • Journal Title

      Diabetes Res Clin Pract

      Volume: 98

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative analysis of cystoid macular edema using scanning laser ophthalmoscope in modified dark-field imaging2012

    • Author(s)
      Katome T、Mitamura Y、Nagasawa T、Eguchi H, Naito T
    • Journal Title

      Retina

      Volume: 32 Issue: 9 Pages: 1892-1899

    • DOI

      10.1097/iae.0b013e3182497141

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of promyelocytic leukemia protein and vascular endothelial growth factor in aqueous humor and vitreous fluid in patients with proliferative diabetic retinopathy.2012

    • Author(s)
      Katome T, et al.
    • Journal Title

      Diabetes Res Clin Pract

      Volume: 98 Issue: 2 Pages: 9-11

    • DOI

      10.1016/j.diabres.2012.09.020

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diagnostic imaging in patients with retinitis pigmentosa2012

    • Author(s)
      Mitamura Y, et al
    • Journal Title

      J Med Invest

      Volume: 59 Pages: 1-11

    • NAID

      130004465252

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Foveal microstructure on spectral-domam optical coherence tomographic images and visual function after macular hole surgery2011

    • Author(s)
      Ooka E, et al
    • Journal Title

      Am J Ophthalmol

      Volume: 152 Issue: 2 Pages: 283-290

    • DOI

      10.1016/j.ajo.2011.02.001

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcription factor, SP1, in epiretinal membranes of patients with proliferative diabetic retinopathy2010

    • Author(s)
      Yoshida-Hata N、Mitamura Y、Oshitari T、Namekata K、Harada C、Harada T、Yamamoto S
    • Journal Title

      Diabetes Res Clin Pract

      Volume: 87 Issue: 3 Pages: e26-e28

    • DOI

      10.1016/j.diabres.2009.12.008

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transcription factor, SP1, in epiretinal membranes of patients with proliferative diabetic retinopathy.2010

    • Author(s)
      Yoshida-Hata N, et al
    • Journal Title

      Diabetes Res Clin Pract

      Volume: 87

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 増殖糖尿病網膜症の眼内における PML 発現の解析2012

    • Author(s)
      香留崇
    • Organizer
      第18回日本糖尿病眼学会総会
    • Place of Presentation
      アクロス福岡(福岡市)
    • Year and Date
      2012-11-02
    • Related Report
      2012 Final Research Report
  • [Presentation] 増殖糖尿病網膜症の眼内におけるPML発現の解析2012

    • Author(s)
      香留崇
    • Organizer
      第18回日本糖尿病眼学会総会
    • Place of Presentation
      アクロス福岡(福岡県)
    • Related Report
      2012 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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