Elucidation of the role of ER stress in neuronal abnormalities of diabetic retinopathy
| Project/Area Number |
22591931
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Chiba University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 眼細胞生物学 / AGE / 網膜3次元培養 / 神経細胞死 / 神経突起再生 / NT-4 / AIF / caspase-9 / 糖尿病網膜症 / 小胞体ストレス / c-Jun / JNK / crosstalk / 神経保護 / 高濃度グルコース / ER stress / cross-talk |
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| Research Abstract |
We have demonstrated that mitochondria-caspase dependent cell death pathways are associated with neuronal cell death in cultured rat retinas under diabetic stress. In addition, we have suggested that ER stress-related cell death pathways are related to neuronal cell death in cultured diabetic rat retinas and in human diabetic retinas. Taken together, our results indicate that there are a molecular crosstalk between mitochondria and ER stress cell death pathways in diabetic retinas. Furthermore, BDNF, NT-4 and citicoline rescued neuronal cell death and induce neurite regeneration in cultured diabetic rat retinas. Especially NT-4 showed the most neuroprotective and regenerative effect in damaged retinal neurons of diabetic retinas.
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Report
(4 results)
Research Products
(33 results)
