| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
We have demonstrated that mitochondria-caspase dependent cell death pathways are associated with neuronal cell death in cultured rat retinas under diabetic stress. In addition, we have suggested that ER stress-related cell death pathways are related to neuronal cell death in cultured diabetic rat retinas and in human diabetic retinas. Taken together, our results indicate that there are a molecular crosstalk between mitochondria and ER stress cell death pathways in diabetic retinas. Furthermore, BDNF, NT-4 and citicoline rescued neuronal cell death and induce neurite regeneration in cultured diabetic rat retinas. Especially NT-4 showed the most neuroprotective and regenerative effect in damaged retinal neurons of diabetic retinas.
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