Experimental study of suprachoroidal drug delivery

Research Project

Project/Area Number	22591933
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Ophthalmology
Research Institution	University of Toyama
Principal Investigator	HAYASHI Atsushi 富山大学, 大学院・医学薬学研究部(医学), 教授 (20283773)
Co-Investigator(Kenkyū-buntansha)	MITARAI Keiichi 富山大学, 大学病院, 助教 (50527918) 藤野貴啓富山大学, 大学病院, 助教 (80565052) 張学云富山大学, 大学院・医学薬学研究部(医学), 助教 (40324040)
Project Period (FY)	2010 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	眼組織学 / ドラッグデリバリー / 後眼部
Research Abstract	We designed a method to deliver drugs into the eye for a relatively long term by delivering collagen gel and steroid into the suprachoroidal space between the sclera and the choroid. We examined the injected collagen gel histologically. As results, we found the collagen gel disappeared from the suprachoroidal space by 3 months after injection. The intraocular concentrations of the steroid mixed with the collagen gel were not significantly different from those of the steroid only during 3 months.