Experimental study of suprachoroidal drug delivery
Project/Area Number |
22591933
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Ophthalmology
|
Research Institution | University of Toyama |
Principal Investigator |
HAYASHI Atsushi 富山大学, 大学院・医学薬学研究部(医学), 教授 (20283773)
|
Co-Investigator(Kenkyū-buntansha) |
MITARAI Keiichi 富山大学, 大学病院, 助教 (50527918)
藤野 貴啓 富山大学, 大学病院, 助教 (80565052)
張 学云 富山大学, 大学院・医学薬学研究部(医学), 助教 (40324040)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 眼組織学 / ドラッグデリバリー / 後眼部 |
Research Abstract |
We designed a method to deliver drugs into the eye for a relatively long term by delivering collagen gel and steroid into the suprachoroidal space between the sclera and the choroid. We examined the injected collagen gel histologically. As results, we found the collagen gel disappeared from the suprachoroidal space by 3 months after injection. The intraocular concentrations of the steroid mixed with the collagen gel were not significantly different from those of the steroid only during 3 months.
|
Report
(4 results)
Research Products
(2 results)