Development of novel endothelial keratoplasty (nDSAEK) for bullous keratopathy and its visual function analysis
| Project/Area Number |
22591934
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 角膜移植 / 角膜内皮移植 / 角膜内皮移植術 / DSAEK / nDSAEK / 共焦点顕微鏡 / 水疱性角膜症 |
|---|
| Research Abstract |
According to a research project, we conducted a research to compare the clinical results after DSAEK(Descemet stripping automated endothelial keratoplasty)and nDSAEK(non-Descemet stripping automated endothelial keratoplasty). As a result, no statistical difference was observed between these two groups in terms of the visual acuity, and best corrected visual acuity, endothelial cell density. Also, no differencewas observed for donor adherence rate. In vivo laser confocal microscopy revealed that subepithelial opacity, stromal needle shaped bodies, donor recipient interface opacity and particles. Most notably, giant hyperreflective materials were observed at donor recipient interface only in nDSAEK group; these were considered to be necrotic and aggregated host endothelial cells and seemed to have no side effect to postoperative visual acuity.
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Report
(4 results)
Research Products
(56 results)
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[Journal Article] Mathematical projection model of corneal endothelial cell loss due to Fuchs corneal dystrophy2011
Author(s)
Hatou S, Shimmura S, Shimazaki J, Usui T, Amano S, Yokogawa H, Kobayashi A, Shiraishi A, Ohashi Y, Inatomi T, Kinoshita S, Tsubota K
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Journal Title
Invest Ophthalmol Vis Sci
Volume: 52
Issue: 11
Pages: 7888-7893
DOI
Related Report
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[Journal Article] Mathematical projection model of corneal endothelial cell loss due to Fuchs corneal dystrophy. 2011:52:7888-78932011
Author(s)
Hatou S, Shimmura S, Shimazaki J, Usui T, Amano S, Yokogawa H, Kobayashi A, Shiraishi A, Ohashi Y, Inatomi T, Kinoshita S, Tsubota K
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Journal Title
Invest Ophthalmol Vis Sci
Volume: 52
Pages: 7888-7893
Related Report
Peer Reviewed
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[Presentation] 角膜内皮移植2011
Author(s)
小林 顕
Organizer
第1回 林眼科オープン手術カンファランス
Place of Presentation
林眼科 福岡県
Year and Date
2011-03-05
Related Report
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[Presentation] 角膜内皮移植2011
Author(s)
小林顕
Organizer
第1回林眼科オープン手術カンファランス
Place of Presentation
林眼科福岡県(招待講演)
Year and Date
2011-03-05
Related Report
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