Active site hypothesis for progression of glaucomatous optic neuropathy and optic disc hemorrhage, and research for prediction of progression
| Project/Area Number |
22591936
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
HIGASHIDE Tomomi 金沢大学, 大学病院, 講師 (20291370)
OHKUBO Shinji 金沢大学, 医学系, 講師 (90362003)
TAKEDA Hisashi 金沢大学, 医学系, 協力研究員 (40436811)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 乳頭出血 / 緑内障性視神経症 / ＯＣＴ / 網膜神経線維層欠損 / 正常眼圧緑内障 / 危険因子 / OCT / 緑内障 / 視神経障害 |
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| Research Abstract |
To elucidate the pathogenesis of glaucoma progression, we measured retinal nerve fiber layer defects (RNFLD) angles and divided normal-tension glaucoma (NTG) cases into 2 groups, enlarged RNFLD and stable RNFLD. Disc hemorrhages were found significantly more frequent in the enlarged group than in the stable group. RNFLD enlarged in the direction of disc hemorrhage in over 80% of eyes. In majority of eyes of the enlarged group, the enlargement of RNFLD was toward the fovea. The enlargement of RNFLD in NTG was closely associated with disc hemorrhage occurrence and the deterioration of visual field.
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Report
(5 results)
Research Products
(40 results)
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[Journal Article] 緑内障研究の進歩原発開放隅角緑内障(広義)への挑戦臨床的諸問題とその科学的解決2012
Author(s)
杉山和久, 東出朋巳, 大久保真司, 新田耕治, 武田久, 奥田徹彦, 桜井真由美, 長田敦, 斎藤代志明, 高橋真美, 前田有, 辻屋壮介, 室谷英治, 若林祐佳, 高延琳, 中谷雄介, 馬渡嘉郎, 川口一朗, 川口千晶, 岡村均, 可児一孝, 樋田一徳, 岩瀬愛子, 川瀬和秀, 兼子博章, 福平由佳子
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Journal Title
日本眼科学会雑誌
Volume: 116(3)
Pages: 233-268
NAID
Related Report
Peer Reviewed
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