Identification of candidate genes responsible for an increased susceptibility of age-related macular degeneration using an animal model and its application to gene diagnosis.
| Project/Area Number |
22591939
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Ophthalmology
|
|---|
| Research Institution | Hamamatsu University School of Medicine |
|---|
Principal Investigator |
OHISHI Kentaro 浜松医科大学, メディカルフォトニクス研究センター, 助教 (80345826)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HOSONO Katsuhiro 浜松医科大学, 医学部, 助教 (60402260)
OBANA Akira 浜松医科大学, メディカルフォトニクス研究センター, 客員教授 (40194625)
HOTTA Yoshihiro 浜松医科大学, 医学部, 教授 (90173608)
MINOSHIMA Shinsei 浜松医科大学, メディカルフォトニクス研究センター, 教授 (90181966)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | 網膜光障害 / 連続戻し交配 / モリス水迷路 / 多型解析 / 加齢黄斑変性 / 戻し交配 / ラット / アポトーシス / 1塩基多型 / 感受性 |
|---|
| Research Abstract |
To elucidate the mechanism underlying the molecular pathogenesis of age-related macular degeneration (AMD), we employed a rat experimental model of retinal photic injury induced by bright, white light exposure. Since the injury susceptibility depends on the rat strain, we started to identify a gene responsible for the susceptibility . In this study, we narrowed down the gene-containing region to 0.99 Mb on rat chromosome 5. It is thought that the 0.99 Mb region contains a key gene which also affects the pathogenesis of AMD. In future, we will identify the responsible gene, and eventually to harness it for an etiology of AMD.
|
Report
(4 results)
Research Products
(20 results)
-
-
-
-
-
[Presentation] Genetic Analysis of Rat Strain-dependent Difference in the Susceptibility to Retinal Photic Injury and Mapping Possible Susceptibility Loci2011
Author(s)
Ohishi, K., Hosono, K., Obana, A., Hotta, Y., Hiramitsu, T., Minoshima, T
Organizer
4th International Conference on Health and Longevity Sciences (ICHALS)
Place of Presentation
Shizuoka
Year and Date
2011-10-21
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
