Involvement of Apelin/APJ system in intraocular neovascularizatio
| Project/Area Number |
22591942
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|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Osaka University |
|---|
Principal Investigator |
GOMI Fumi 大阪大学, 医学系研究科, 招へい教員 (80335364)
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|---|
| Co-Investigator(Kenkyū-buntansha) |
OSHIMA Yusuke 大阪大学, 医学系研究科, 講師 (20362717)
SUZUKI Mihoko 大阪大学, 医学部附属病院, 医員 (40611166)
IKUNO Yasushi 大阪大学, 医学系研究科, 講師 (50294096)
SAWA Miki 大阪大学, 医学系研究科, 助教 (50403043)
BABA Akemichii 大阪大学, 薬学部, 教授 (70107100)
KASAI Atushi 摂南大学, 薬学部, 助教 (40454649)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | アペリン / 血管新生 / 網膜 / 脈絡膜 |
|---|
| Research Abstract |
Apelin induces the hypoxia-induced retinal angiogenesisindependent of the VEGF/VEGF receptor 2 signaling pathway. Apelin is also involved in the development of choroidal neovascularization. Therefore, a therapy targeting of apelin possibly rescues nonresponders for anti-VEGF treatment.
|
Report
(4 results)
Research Products
(64 results)
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[Journal Article] Transcriptional Regulation of VEGFA by the Endoplasmic Reticulum Stress Transducer OASIS in ARPE-19 Cells.2013
Author(s)
Miyagi H, Kanemoto S, Saito A, Asada R, Iwamoto H, Izumi S, Kido M, Gomi F, Nishida K, Kiuchi Y, Imaizumi K.
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Journal Title
PLOS ONE
Volume: 8
Issue: 1
Pages: 55155-55155
DOI
Related Report
Peer Reviewed
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[Journal Article] Apelin Is a Crucial Factor for Hypoxia-Induced Retinal Angiogenesis.2010
Author(s)
Kasai A, Ishimaru Y, Kinjo T, Satooka T, Matsumoto N, Yoshioka Y, Yamamuro A, Gomi F, Shintani N, Baba A, Maeda S.
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Journal Title
Arterioscler Thromb Vasc Biol.
Volume: 30
Issue: 11
Pages: 2182-7
DOI
Related Report
Peer Reviewed
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[Presentation] 眼底自発蛍光2011
Author(s)
五味文
Organizer
第115回日本眼科学会総会
Place of Presentation
名古屋(招待講演)
Year and Date
2011-04-15
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