Sex Hormone Effect on FGF7 Signaling andApplication for Dry Eye
| Project/Area Number |
22591943
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Ehime University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OHASHI Yuichi 愛媛大学, 大学院・医学系研究科, 教授 (00116005)
小林 剛 愛媛大学, 医学(系)研究科(研究院), 寄附講座助教 (70380285)
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| Co-Investigator(Renkei-kenkyūsha) |
KOBAYASHI Takeshi 愛媛大学, 大学院・医学系研究科, 寄附講座助教 (70380285)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | マイボーム腺 / 線維芽細胞増殖因子7 / 性ホルモン / ドライアイ / 遺伝子組換えマウス / 線維芽細胞増殖因子７ / 遺伝子組み換えマウス / 眼瞼 / 上皮 / ドキシサイクリン |
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| Research Abstract |
Dry eye disease, a major cause of ocular surface irritation, is not only greatly enhance their vision, but also their quality of life. To elucidate molecular mechanism of the reason why women are more likely to develop dry eyes, in this study, we found the effect on cell proliferation of Meibomian gland tissues by Fibroblast growth factor 7.
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] Important role of epiregulin in inflammatory responses during corneal epithelial wound healing2012
Author(s)
Zhang, Y., Kobayashi, T., Hayashi, Y., Yoshioka, R., Shiraishi,A., Shirasawa, S., Higashiyama, S., Ohashi, Y
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Journal Title
Invest Ophthalmol Vis Sci
Volume: 53
Pages: 2414-2423
Related Report
Peer Reviewed
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[Journal Article] Involvement of stem cell factor and c-kit in corneal wound healing inmice2012
Author(s)
Miyamoto, K., Kobayashi, T., Hayashi, Y., Zhang, Y., Hara, Y., Higashine, M., Shiraishi, A., Ohashi, Y
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Journal Title
Mol Vis
Volume: 18
Pages: 1505-1515
Related Report
Peer Reviewed
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[Journal Article] Assessment of real-time polymerase chain reaction detection of Acanthamoeba and prognosis determinants of Acanthamoeba keratitis2012
Author(s)
Ikeda, Y., Miyazaki, D., Yakura, K., Kawaguchi, A., Ishikura, R., Inoue, Y., Mito, T., Shiraishi, A., Ohashi, Y., Higaki, S., Itahashi, M., Fukuda, M., Shimomura, Y., Yagita
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Journal Title
K.Ophthalmology
Volume: 119
Pages: 1111-1119
Related Report
Peer Reviewed
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[Journal Article] Crosstalk between TGF-beta and MAPK signaling during corneal wound healing2011
Author(s)
Terai, K., Call, M. K., Liu, H., Saika, S., Liu, C. Y., Hayashi, Y., Chikama, T., Zhang, J., Terai, N., Kao, C. W., Kao
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Journal Title
W. W. Invest Ophthalmol Vis Sci
Volume: 52
Pages: 8208-8215
Related Report
Peer Reviewed
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[Journal Article] Anterior segment optical coherence tomography analysis of clinically unilateral pseudoexfoliation syndrome: evidence of bilateral involvement and morphologic factors related to asymmetry.2011
Author(s)
Zheng, X., Sakai, H., Goto, T., Namiguchi, K., Mizoue, S., Shiraishi, A., Sawaguchi, S., Ohashi, Y
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Journal Title
Invest Ophthalmol Vis Sci
Volume: 52
Pages: 5679-5684
Related Report
Peer Reviewed
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[Journal Article] In vivo confocal microscopic evidence of keratopathy in patients with pseudoexfoliation syndrome2011
Author(s)
Zheng, X., Shiraishi, A., Okuma, S., Mizoue, S., Goto, T., Kawasaki, S., Uno, T., Miyoshi, T., Ruggeri, A., Ohashi, Y
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Journal Title
Invest Ophthalmol Vis Sci
Volume: 52
Pages: 1755-1761
Related Report
Peer Reviewed
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[Journal Article] Lumican is required for neutrophil extravasation following corneal injury and wound healing2010
Author(s)
Hayashi Y, Call MK, Chikama T, Liu H, Carlson EC, Sun Y, Pearlman E, Funderburgh JL, Babcock G, Liu CY, Ohashi Y, Kao W
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Journal Title
Journal of Cell Science
Volume: 123
Pages: 2987-2995
Related Report
Peer Reviewed
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