| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
We investigated the analysis of neural metabolites in optic nerve diseases in vivo by proton magnetic resonance spectroscopy(1H-MRS) on 3-Tesal high resolution MRI. We could measure the concentration of cortical metabolites in the human visual cortex (V1). The N-acetyl aspartate (NAA) of the V1 in the severe optic atrophy reduced compared with normal control group. In glaucomatous optic atrophy, the reduction of NAA was associated with the severity of visual field defects. In an experimental in vitro study, 1H-MRS using 7-Tesla MRI revealed reduced NAA in V1 of glaucoma model rats during the chronic disease phase by.
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