Analysis of neural metabolites of optic nerve disease using high-spatial-resolution MRI
| Project/Area Number |
22591944
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OHGURO Hiroshi 札幌医科大学, 医学部, 教授 (30203748)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 視神経 / MR スペクトロスコピー / 緑内障 / 視中枢 / MRスペクトロスコピー / MRI / NMDA / N-アセチルアスパラギン酸 |
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| Research Abstract |
We investigated the analysis of neural metabolites in optic nerve diseases in vivo by proton magnetic resonance spectroscopy(1H-MRS) on 3-Tesal high resolution MRI. We could measure the concentration of cortical metabolites in the human visual cortex (V1). The N-acetyl aspartate (NAA) of the V1 in the severe optic atrophy reduced compared with normal control group. In glaucomatous optic atrophy, the reduction of NAA was associated with the severity of visual field defects. In an experimental in vitro study, 1H-MRS using 7-Tesla MRI revealed reduced NAA in V1 of glaucoma model rats during the chronic disease phase by.
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Report
(4 results)
Research Products
(17 results)
