Study on molecular mechanism causing cancer-associated retinopathy by aberrant expression of photoreceptor specific recoverin
| Project/Area Number |
22591945
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ISHIKAWA Futoshi 札幌医科大学, 医学部, 講師 (00419962)
MAEDA Kimihito 札幌医科大学, 医学部, 助教 (00452970)
OHGURO Ikuyo 札幌医科大学, 医学部, 研究員 (90305235)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 癌関連網膜症 / リカバリン / 異所性発現 / 自己免疫 / Ca^<2+>結合蛋白質 / カベオリン / 網膜色素変性 |
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| Research Abstract |
T o elucidate the molecular pathology in CAR, expressions of recoverin were examined. Recoverin was identified to be expressed in 30-70% of cancer tissues. We observed co-precipitation of G-protein-coupled-kinases (GRKs) and caveolin-1 with Rec from cell lysates of 293 or SSTW cells. Immunocytechemistry revealed that immunoreactivitiestoward recoverin within the cancer cells were almost identical to those toward GRKs and caveolin-1. The present data strongly suggests that aberrantly expressed recoverin should be involved in the GRK-dependent cellular regulation in cancer cells.
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Report
(4 results)
Research Products
(57 results)
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[Journal Article] Identification of autoantibodies against TRPM1 in patients with paraneoplastic retinopathy associated with ON bipolar cell dysfunction2011
Author(s)
Kondo M, Sanuki R, Ueno S, Nishizawa Y, Hashimoto N, Ohguro H, Yamamoto S, Machida S, Terasaki H, Adamus G, Furukawa T
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Journal Title
PLOS ONE
Volume: 6(5)
Pages: 1-7
Related Report
Peer Reviewed
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