Research of pathophysiology of age-related macular degeneration using quantitative analysis of retinal photoreceptor and retinal pigment epithelial function
Project/Area Number |
22591946
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Ophthalmology
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Research Institution | Tokyo Women's Medical University (2012) Fukushima Medical University (2010-2011) |
Principal Investigator |
IIDA Tomohiro 東京女子医科大学, 医学部, 教授 (50241881)
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Co-Investigator(Kenkyū-buntansha) |
SEKIRYU Tetsuju 福島県立医科大学, 医学部, 教授 (00216540)
MARUKO Ichiro 福島県立医科大学, 医学部, 講師 (10443871)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2011: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2010: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
|
Keywords | 加齢黄斑変性 / 眼底自発蛍光 / 定量化 / 視細胞 / 網膜色素上皮細胞 |
Research Abstract |
We made a new filter (>555nm) to record green fundus autofluorescence (FAF) to remove the influence the crystalline lens condition and macular pigment. To quantify the intensity of FAF, we built in a fluorescent reference board into the scanning laser ophthalmoscope (SLO). However, the intensity of FAF varied depending on the grade of cataract. We added on another new correction system. The intensity of light on the retina was corrected by the ratio of infrared/green light. Infrared reference was built into the SLO for this aim.
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Report
(4 results)
Research Products
(59 results)
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[Journal Article] Significance of C2/CFB variants in age-related macular degeneration and polypoidal choroidal vasculopathy in a Japanese population2012
Author(s)
Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, Akagi-Kurashige Y, Tsujikawa A, Otani A, Saito M, Iida T, Oishi A, Matsuo K, Tajima K, Matsuda F, Yoshimura N
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Journal Title
Invest Ophthalmol Vis Sci
Volume: 53
Issue: 2
Pages: 794-798
DOI
Related Report
Peer Reviewed
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[Journal Article] Epidemiological and virological features of epidemic keratoconjunctivitis due to new human adenovirus type 54 in Japan2011
Author(s)
Kaneko H, Suzutani T, Aoki K, Kitaichi N, Ishida S, Ishiko H, Ohashi T, Okamoto S, Nakagawa H, Hinokuma R, Asato Y, Oniki S, Hashimoto T, Iida T, Ohno S.
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Journal Title
Br J Ophthalmol
Volume: 95
Issue: 1
Pages: 32-36
DOI
Related Report
Peer Reviewed
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[Journal Article] Long-term efficacy and safety of ranibizumab administered pro renata in Japanese patients with neovascular age-related macular degeneration2011
Author(s)
Tano Y, Ohji M; EXTEND-1 study group (Iida T, Ishibashi T, Ishida S, Kishi S, Ohji M, Okada AA, Sato Y, Shiraga F, Shiraki K, Tano Y, Terasaki H, Yuzawa M)
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Journal Title
Acta Ophthalmol
Volume: 89
Issue: 3
Pages: 208-217
DOI
Related Report
Peer Reviewed
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[Journal Article] Genetic variants in pigment epithelium-derived factor influence response of polypoidal choroidal vasculopathy to photodynamic therapy2011
Author(s)
Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, Tsujikawa A, Otani A, Ooto S, Tamura H, Saito M, Saito K, Iida T, Oishi A, Kurimoto Y, Matsuda F, Yoshimura N
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Journal Title
Ophthalmology
Volume: 118
Issue: 7
Pages: 1408-15
DOI
Related Report
Peer Reviewed
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[Journal Article] Association between the SERPING1 gene and age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese2011
Author(s)
Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, Tsujikawa A, Otani A, Saito M, Iida T, Oishi A, Matsuo K, Tajima K, Matsuda F, Yoshimura N
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Journal Title
PLoS One
Volume: 6
Issue: 4
Pages: e19108-e19108
DOI
Related Report
Peer Reviewed
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[Journal Article] Association of elastin gene polymorphism to age-related macular degeneration and polypoidal choroidal vasculopathy2011
Author(s)
Yamashiro K, Mori K, Nakata I, Tsuchihashi T, Horie-Inoue K, Nakanishi H, Tsujikawa A, Saito M, Iida I, Yamada R, Matsuda F, Inoue S, Awata T, Yoneya S, Yoshimura N
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Journal Title
Invest Ophthalmol Vis Sci
Volume: 52
Issue: 12
Pages: 8780-8784
DOI
Related Report
Peer Reviewed
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[Journal Article] ARMS2/HTRA1 and CFH polymorphisms are not associated with choroidal neovascularization in highly myopic eyes of elderly Japanese population.2010
Author(s)
Nakanishi H, Gotoh N, Yamada R, Yamashiro K, Otani A, Hayashi H, Tsujikawa A, Shimada N, Obno-Matsui K, Mochizuki M, Saito M, Saito K, Iida T, Matsuda F, Yoshimura N.
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Journal Title
Eye
Volume: 24
Pages: 1078-1084
Related Report
Peer Reviewed
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[Journal Article] Single nucleotide polymorphisms in promoter region of matrix metalloproteinase 1,2, and 3 in Japanese with high myopia.2010
Author(s)
Nakanishi H, Hayashi H, Yamada R, Yamashiro K, Nakata I, Shimada N, Ohno-Matsui K, Mochizuki M, Ozaki M, Yoshitake S, Kuriyama S, Saito M, Iida T, Matsuo K, Matsuda F, Yoshimura N.
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Journal Title
Invest Ophthalmol Vis Sci
Volume: 51
Pages: 4432-4436
Related Report
Peer Reviewed
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[Journal Article] CFH and ARMS2 variations in age-related macular degeneration, polypoidal choroidal vasculopathy, and retinal angiomatous proliferation.2010
Author(s)
Hayashi H, Yamashiro K, Gotoh N, Nakanishi H, Nakata I, Tsujikawa A, Otani A, Saito M, Iida T, Matsuo K, Tajima K, Yamada R, Yoshimura N.
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Journal Title
Invest Ophthalmol Vis Sci
Volume: 51
Pages: 5914-5919
Related Report
Peer Reviewed
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[Journal Article] Epidemiological and virological features of epidemic keratoconjunctivitis due to new human adenovirus type 54 in Japan.2010
Author(s)
Kaneko H, Suzutani T, Aoki K, Kitaichi N, Ishida S, Ishiko H, Ohashi T, Okamoto S, Nakagawa H, Hinokuma R, Asato Y, Oniki S, Hashimoto T, Iida T, Ohno S.
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Journal Title
Br J Ophthalmol
Volume: 95
Pages: 32-36
Related Report
Peer Reviewed
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[Journal Article] Joint effect of cigarette smoking, CFH and LOC387715/HTRA1 polymorphisms on polypoidal choroidal vasculopathy.2010
Author(s)
Nakanishi H, Yamashiro K, Yamada R, Gotoh N, Hayashi H, Nakata I, Saito M, Iida T, Oishi A, Kurimoto Y, Matsuo K, Tajima K, Matsuda F, Yoshimura N.
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Journal Title
Invest Ophthalmol Vis Sci
Volume: 51
Pages: 6183-6187
Related Report
Peer Reviewed
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