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Development of a new strategy for the prevention of ocular tissue fibrosis by targeting integrin-Smad craootalks

Research Project

Project/Area Number 22591948
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionWakayama Medical University

Principal Investigator

SAIKA Shizuya  和歌山県立医科大学, 医学部, 教授 (40254544)

Co-Investigator(Kenkyū-buntansha) OKADA Yuka  和歌山県立医科大学, 医学部, 講師 (50264891)
SHIRAI Kumi  和歌山県立医科大学, 医学部, 講師 (70326370)
MIYAMOTO Takeshi  和歌山県立医科大学, 医学部, 講師 (20336879)
Project Period (FY) 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsインテグリン / Smad / 線維化 / 眼 / マウス / オステオポンチン / 中和抗体 / 創傷治癒 / 組織線維化 / アルカリ角膜外傷 / 水晶体外傷 / ミドルリンカー / テネイシン
Research Abstract

The expression of extracellular matrix components and fibrotic cytokines in fibroblasts, which were from either osteopontin (OPN) or tenascin C (TNC), both of which are ligands of a9 integrin, knock-out and wild-type mice, were examined. Lacking OPN or TNC decreased the expression of type I collagen, TGF-b1, and alpha-smooth muscle actin. However OPN signaling is directly involved in phosphorylation of Smad3 and p38, the lack of TNC did not affect Smad3 expression levels or phosphorylation. The effects of TNC knock-out on wound healing models, which were scar healing after corneal incision and corneal angiogenesis, were examined. The lack of TNC inhibited both scarring and angiogenesis. The effects of OPN knock-out on another wound healing models associated with angiogenesis, which were angiogenesis and scar tissue formation after laser irradiation on choroid and retina, were examined. The effects of dose of OPN neutralizing antibody were also examined before intraperitoneal administration of a9 integrin neutralizing antibody .Lacking OPN or blocking its signaling induced by systemic administration of an OPN neutralizing antibody suppressed the expression of inflammatory cytokines, choroidal neovascularization and scar tissue formation. Controlling OPN or TNC signaling would be a new treatment strategy for ocular scarring or diseases associated with angiogenesis.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (74 results)

All 2013 2012 2011 2010 Other

All Journal Article (42 results) (of which Peer Reviewed: 41 results) Presentation (32 results) (of which Invited: 4 results)

  • [Journal Article] Errors in the prediction of postoperative refraction following intraocular lens implantation in eyes with pseudoexfoliation syndrome2013

    • Author(s)
      Ishikawa N, Hayashi Y, Miyamoto T, Saika S
    • Journal Title

      J Cataract Refract Surg

      Volume: 39(4) Issue: 4 Pages: 649-650

    • DOI

      10.1016/j.jcrs.2013.02.023

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cannabinoid receptor 1 suppresses transient receptor potential vanilloid 1-induced inflammatory responses to corneal injury.2012

    • Author(s)
      Yang Y, Yang H, Wang Z, Varadaraj K, Kumari SS, Mergler S, Okada Y, Saika S, Kingsley PJ, Marnett LJ, Reinach PS.
    • Journal Title

      Cell Signal

      Volume: 25(2) Issue: 2 Pages: 501-11

    • DOI

      10.1016/j.cellsig.2012.10.015

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impaired cornea wound healing in a tenascin C-deficient mouse model2012

    • Author(s)
      Sumioka T, Kitano A, Flanders KC, Okada Y, Yamanaka O, Fujita N, Iwanishi H, Kao WW, Saika S
    • Journal Title

      Lab Invest

      Volume: 93(2) Issue: 2 Pages: 207-17

    • DOI

      10.1038/labinvest.2012.157

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Wakayam symposium: epithelial-mesenchymal interaction regulates tissue formation and characteristics:insights for corneal development2012

    • Author(s)
      Suzuki K, Yokoyama C, Higashi Y, Daikoku T, Mizoguchi S, Saika S, Yamada G.
    • Journal Title

      Ocul Surf

      Volume: 10(4) Issue: 4 Pages: 217-20

    • DOI

      10.1016/j.jtos.2012.07.007

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Wakayama symposium: current concepts of ocular surface.cell biology2012

    • Author(s)
      Saika S
    • Journal Title

      Ocul Surf

      Volume: 10(4) Issue: 4 Pages: 210-1

    • DOI

      10.1016/j.jtos.2012.07.006

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A patient with corneal epithelial disorder that developed after administration of a latanoprost generic, but not a brand-name drug, eye drop.2012

    • Author(s)
      Takada Y, Okada Y, Fujita N, Saika S.
    • Journal Title

      Case Rep Ophthalmol Med

      Volume: N/A Pages: 536746-536746

    • DOI

      10.1155/2012/536746

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endogenous osteopontin involvement in laser-induced choroidal neovascularization in mice.2011

    • Author(s)
      Fujita N, Fujita S, Ogata N, Matsuoka M, Okada Y, Kon S, Uede T, Saika S.
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 52(13) Pages: 9310-5

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Crosstalk between TGF-beta and MAPK signaling during corneal wound healing.2011

    • Author(s)
      Terai K, Call MK, Liu H, Saika S, Liu CY, Hayashi Y, Chikama T, Zhang J, Terai N, Kao CW, Kao WW.
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 52(11) Pages: 8208-15

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] TRPV1 involvement in inflammatory tissue fibrosis in mice.2011

    • Author(s)
      Okada Y, Reinach PS, Shirai K, Kitano A, Kao WW, Flanders KC, Miyajima M, Liu H, Zhang J, Saika S.
    • Journal Title

      Am Jpathol

      Volume: 178(6) Pages: 2654-64

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impaired angiogenic response in the cornea of mice lacking tenascin C2011

    • Author(s)
      Sumioka T, Fujita N, Kitano A, Okada Y, Saika S
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 52(5) Pages: 2462-7

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impaired Angiogenic Response in the Cornea of Mice Lacking Tenascin C2011

    • Author(s)
      Sumioka T, Fujita N, Kitano A, Okada Y, Saika S
    • Journal Title

      Investigative Ophthalmology and Visual Science

      Volume: 52 Issue: 5 Pages: 2462-2467

    • DOI

      10.1167/iovs.10-5750

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] TRPV1 involvement in inflammatory tissue fibrosis in mice2011

    • Author(s)
      Okada Y, Reinach PS, Shirai K, Kitano A, Kao WW, Flanders KC, Miyajima M, Liu H, Zhang J, Saika S
    • Journal Title

      Am JPathol

      Volume: 178(6) Issue: 6 Pages: 2654-64

    • DOI

      10.1016/j.ajpath.2011.02.043

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cell adhesion on explanted intraocular lenses : part 1 : analysis of explanted IOL2011

    • Author(s)
      Ishikawa N, Miyamoto T, Okada Y, Saika S
    • Journal Title

      J Cataract Refract Surg

      Volume: 37(7) Issue: 7 Pages: 1333-8

    • DOI

      10.1016/j.jcrs.2011.04.001

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cell adhesion on explanted intraocular lenses part 2 : experimental study of a surfece-modified IOL in rabbits2011

    • Author(s)
      Ishikawa N, Miyamoto T, Okada Y, Saika S
    • Journal Title

      J Cataract Refract Surg

      Volume: 37(7) Issue: 7 Pages: 1339-42

    • DOI

      10.1016/j.jcrs.2011.04.002

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crosstalk between TGF-beta and MAPK signaling during corneal wound healing2011

    • Author(s)
      Terai K, Call MK, Liu H, Saika S, Liu CY, Hayashi Y, Chikama T, Zhang J, Terai N, Kao CW, Kao WW
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 52(11) Issue: 11 Pages: 8208-15

    • DOI

      10.1167/iovs.11-8017

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endogenous osteopontin involvement in laser-induced choroidal neovascularization in mice2011

    • Author(s)
      Fujita N, Fujita S, Ogata N, Matsuoka M, Okada Y, Kon S, Uede T, Saika S
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 52(13) Issue: 13 Pages: 9310-5

    • DOI

      10.1167/iovs.10-7050

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 自傷によると思われる角膜障害の1例2011

    • Author(s)
      小門正英, 宮本武, 岡田由香, 雑賀司珠也
    • Journal Title

      眼科臨床紀要

      Volume: 4巻4号 Pages: 279-279

    • NAID

      10031162531

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PPARδの角膜上皮細胞の創傷治癒に及ぼす影響2011

    • Author(s)
      井上晃宏, 岡田由香, 北野愛, 雑賀司珠也
    • Journal Title

      日本眼科学会雑誌

      Volume: 52(11) Pages: 8208-15

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PPARδの角膜上皮細胞の創傷治癒に及ぼす影響2011

    • Author(s)
      高田幸尚, 岡田由香, 北野愛, 石川伸之, 藤田識人, 雑賀司珠也
    • Journal Title

      日本眼科学会雑誌

      Volume: 115巻臨増 Pages: 279-279

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] マウス三叉神経障害モデルの作製2011

    • Author(s)
      岡田由香, 仙波恵美子, 白井久美, 藤田識人, 北野愛, 雑賀司珠也
    • Journal Title

      日本眼科学会雑誌

      Volume: 115巻臨増 Pages: 283-283

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NOS2欠損マウスにおける脈絡膜神経血管の動態2011

    • Author(s)
      藤田識人, 岡田由香, 雑賀司珠也
    • Journal Title

      日本眼科学会雑誌

      Volume: 115巻臨増 Pages: 296-296

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epiplakin欠損での角膜創傷治癒2011

    • Author(s)
      小門正英, 岡田由香, 石川一志, 後藤瑞生, 藤原作平, 雑賀司珠也
    • Journal Title

      日本結合組織学会学術大会・マトリックス研究会大会合同学術集会プログラム・抄録集43回・58回Page136(2011.05)

      Pages: 136-136

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 自己強膜片移植を行った角膜穿孔症例2011

    • Author(s)
      北野愛、岡田由香、白井久美、雑賀司珠也
    • Journal Title

      眼科臨床紀要

      Volume: 4(2) Pages: 148-150

    • NAID

      10031162510

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] インスリン治療後早期に一過性の調節障害を呈した小児I型糖尿病の一例2011

    • Author(s)
      白井久美、岡田由香、北野愛、小久保奈津、乙井あや、雑賀司珠也
    • Journal Title

      眼科臨床紀要

      Volume: 4(2) Pages: 177-179

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 救後麻酔による一過性の眼球運動障害がみられた2症例2011

    • Author(s)
      住岡孝吉、岡田由香、雑賀司珠也
    • Journal Title

      眼科臨床紀要

      Volume: 4(2) Pages: 129-131

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 生体吸収性骨固定プレートを用いたKroenlein手術の1例2011

    • Author(s)
      宮崎賢一、藤田識人、友寄勝夫、田中才一、山中修、森田展雄、雑賀司珠也
    • Journal Title

      臨床眼科

      Volume: 65(1) Pages: 79-83

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 抗菌薬を用いて外来通院で保存的に治療した遅発性術後眼内炎の7症例2011

    • Author(s)
      宮崎賢一、山中修、井上貴久彦、住岡孝吉、西本周子、雑賀司珠也
    • Journal Title

      眼科臨床紀要

      Volume: 4(1) Pages: 34-37

    • NAID

      10031162493

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tissue fibrosis.2010

    • Author(s)
      Saika S
    • Journal Title

      Endocr Metab Immune Disord Drug Targets

      Volume: 10(4) Pages: 301-301

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic potential of Trichostatin A to control inflammatory and fibrogenic disorders of the ocular surface.2010

    • Author(s)
      Kitano A, Okada Y, Yamanka O, Shirai K, Mohan RR, Saika S.
    • Journal Title

      Mol Vis

      Volume: 16 Pages: 2964-73

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transforming growth factor beta signal transduction: a potential target for maintenance/restoration of transparency of the cornea.2010

    • Author(s)
      Saika S, Yamanaka O, Sumioka T, Okada Y, Miyamoto T, Shirai K, Kitano A, Tanaka S.
    • Journal Title

      Eye Contact Lens

      Volume: 36(5) Pages: 286-9

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of injury-induced epithelial-mesenchymal transition in a mouse lens epithelium lacking tenascin-C.2010

    • Author(s)
      Tanaka S, Sumioka T, Fujita N, Kitano A, Okada Y, Yamanaka O, Flanders KC, Miyajima M, Saika S.
    • Journal Title

      Mol Vis

      Volume: 16 Pages: 1194-205

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neurotrophic keratopathy; its pathophysiology and treatment.2010

    • Author(s)
      kada Y, Reinach PS, Kitano A, Shirai K, Kao WW, Saika S.
    • Journal Title

      Histol Histopathol

      Volume: 25(6) Pages: 771-80

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 脈絡膜悪性黒色腫の浸潤、遠隔転移での TGFβ/Smad2/3 シグナル(C 末端およびミドルリンカー領域のリン酸化)と各種MAP キナーゼ系とのクロストークの役割の探索とそれに基づいた治療法の研究(原著論文)2010

    • Author(s)
      雑賀 司珠也
    • Journal Title

      上原記念生命科学財団研究報告集

      Volume: 24巻 Pages: 1-3

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neurotrophic keratopathy ; its pathophysiology and treatment.2010

    • Author(s)
      Okada Y, Reinach PS, Kitano A, Shirai K, Kao WW, Saika S.
    • Journal Title

      Histol Histopathol

      Volume: 25(6) Pages: 771-80

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of injury-induced epithelial-mesenchymal transition in a mouse lens epithelium lacking tenascin-C.2010

    • Author(s)
      Tanaka S, Sumioka T, Fujita N, Kitano A, Okada Y, Yamanaka O, Flanders KC, Miyajima M, Saika S.
    • Journal Title

      Mol Vis.

      Volume: 1(16) Pages: 1194-205

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transforming growth facter beta signal transduction : a potential target for maintenance/restoration of transparency of the cornea.2010

    • Author(s)
      Saika S, Yamanaka O, Sumioka T, Okada Y, Miyamoto T, Shirai K, Kitano A, Tanaka S
    • Journal Title

      Eye Contact Lens.

      Volume: 36(5) Pages: 286-9

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impaired angiogenic response in the cornea of mice lacking tenascin C.2010

    • Author(s)
      Sumioka T, Fujita N, Kitano A, Okada Y, Saika S.
    • Journal Title

      Invest Ophthalmol Via Sci

      Volume: 42(4)(Epub ahead of print)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic potential of Trichostatin A to control inflammatory and fibrogenic disorders of the ocular surface.2010

    • Author(s)
      Kitano A, Okada Y, Yamanka O, Shirai K, Mohan RR, Saika S.
    • Journal Title

      Mol Vis.

      Volume: 31(16) Pages: 2964-2973

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tissue fibrosis.Endocr Metab Immune Disord Drug Targets.2010

    • Author(s)
      Saika S.
    • Journal Title

      Drug Targets.

      Volume: 10(4) Pages: 301-301

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 双生児にみられた網膜血管走行異常2010

    • Author(s)
      宮崎賢一, 山中修, 河島義治, 雑賀司珠也
    • Journal Title

      眼科臨床紀要

      Volume: 64(5) Pages: 797-800

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 免疫再構築症候群の一例2010

    • Author(s)
      洪成勲, .岡田由香, 雑賀司珠也
    • Journal Title

      眼科臨床紀要

      Volume: 3(8) Pages: 768-770

    • NAID

      10030250889

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 脈絡膜悪性黒色腫の浸潤、遠隔転移でのTGFβ/Smad2/3シグナル(C末端およびミドルリンカー領域のリン酸化)と各種MAPキナーゼ系とのクロストークの役割の探索とそれに基づいた治療法の研究2010

    • Author(s)
      雑賀司珠也
    • Journal Title

      上原記念生命科学財団研究報告集

      Volume: 24 Pages: 1-3

    • Related Report
      2010 Annual Research Report
  • [Presentation] 薬剤性角膜上皮障害に関連して2012

    • Author(s)
      雑賀司珠也
    • Organizer
      第67回徳島眼科研究会
    • Place of Presentation
      徳島
    • Year and Date
      2012-03-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 糖尿病網膜症特に黄斑浮腫の病態治療2012

    • Author(s)
      雑賀司珠也
    • Organizer
      和歌山市医師会第13班(吹上地区)勉強会
    • Place of Presentation
      和歌山
    • Year and Date
      2012-01-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] Cornea Endothelium &Storoma2012

    • Author(s)
      雑賀 司珠也
    • Organizer
      Kyoto Cornea Club
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] EMT in the Corneal Endothelium;Involvement of in Diseases and Lts Treatment Strategy.2012

    • Author(s)
      Shizuya Saika
    • Organizer
      ASIA The 27th Asia Pacfic Academy of Ophthalmology Congress
    • Place of Presentation
      Busan
    • Related Report
      2012 Final Research Report
  • [Presentation] イオンチャンネル受容体と実質炎症2012

    • Author(s)
      雑賀 司珠也
    • Organizer
      第116回日本眼科学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] EMT in the Corneal Endothelium;Involvement of in Diseases and Lts Treatment Strategy2012

    • Author(s)
      Shizuya Saika
    • Organizer
      Asia Pacfic Academy of Ophthalmology Congress
    • Place of Presentation
      Busan Korea
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Roles of macrophages and fibroblasts in tissue repair of cornea2011

    • Author(s)
      Shizuya Saika
    • Organizer
      The Ophthalmological Society of Taiwan
    • Place of Presentation
      Taiwan
    • Year and Date
      2011-11-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] 角膜創傷治癒:実質細胞と炎症細胞2011

    • Author(s)
      雑賀司珠也
    • Organizer
      第32回西中国眼疾患フォーラム
    • Place of Presentation
      山口
    • Year and Date
      2011-11-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] ICCEの基本/応用と注意点2011

    • Author(s)
      雑賀司珠也
    • Organizer
      第50回日本白内障学会総会・第26回日本白内障屈折矯正手術学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2011-06-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] 創傷治癒における線維芽細胞と炎症細胞の役割2011

    • Author(s)
      雑賀司珠也
    • Organizer
      第168回発生研セミナー講演会
    • Place of Presentation
      熊本
    • Year and Date
      2011-06-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] Roles of macrophages and fibroblasts in the tissue repair in cornea2011

    • Author(s)
      Shizuya Saika
    • Organizer
      Seoul St.Mary Hospital定期講演会
    • Place of Presentation
      Seoul
    • Year and Date
      2011-05-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] Epithelial-Mesenchymal Transition as a Therapeutic Target in Ocular Fibrotic Diseases2011

    • Author(s)
      Shizuya Saika
    • Organizer
      Seoul St.Mary Hospital定期講演会
    • Place of Presentation
      Seoul
    • Year and Date
      2011-05-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] Post-operative endophthalmitis : Pathology and treatment2011

    • Author(s)
      Shizuya Saika
    • Organizer
      University of California Irvine
    • Place of Presentation
      Los Angeles
    • Year and Date
      2011-04-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Epithelial-mesenchymal transition as a therapeutic target in ocular fibrotic diseases2011

    • Author(s)
      Shizuya Saika
    • Organizer
      University of California Irvine
    • Place of Presentation
      Los Angeles
    • Year and Date
      2011-04-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] 薬剤性角膜上皮障害とその周辺2011

    • Author(s)
      雑賀司珠也
    • Organizer
      第12回とやま眼科学術講演会
    • Place of Presentation
      富山
    • Year and Date
      2011-03-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 糖尿病と眼2011

    • Author(s)
      雑賀司珠也
    • Organizer
      最新の医療カンファランス
    • Place of Presentation
      和歌山
    • Year and Date
      2011-03-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 角膜と創傷治癒2011

    • Author(s)
      雑賀司珠也
    • Organizer
      角膜カンファランス2011
    • Place of Presentation
      東京
    • Year and Date
      2011-02-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] 実質創傷治癒の制御機構:実質細胞と炎症細胞2011

    • Author(s)
      雑賀 司珠也
    • Organizer
      第32回西中国眼疾患フォーラム
    • Place of Presentation
      山口
    • Related Report
      2012 Final Research Report
  • [Presentation] Roles of macrophages and fibroblasts in tissue repair of cornea2011

    • Author(s)
      Shizuya Saika
    • Organizer
      The Ophthalmological Society of Taiwan.
    • Place of Presentation
      Taiwan
    • Related Report
      2012 Final Research Report
  • [Presentation] 創傷治癒における線維芽細胞と炎症細胞の役割2011

    • Author(s)
      雑賀 司珠也
    • Organizer
      第168回発生研セミナー.
    • Place of Presentation
      熊本
    • Related Report
      2012 Final Research Report
  • [Presentation] Epithelial-Mesenchymal Transition as a Therapeutic Target in Ocular Fibrotic Diseases.2011

    • Author(s)
      Shizuya Saika
    • Organizer
      St.Mary hospital 定期講演会
    • Place of Presentation
      Seoul
    • Related Report
      2012 Final Research Report
  • [Presentation] Roles of macrophages and fibroblasts in the tissue repair in cornea2011

    • Author(s)
      Shizuya Saika
    • Organizer
      St.Mary hospital 定期講演会
    • Place of Presentation
      Seoul
    • Related Report
      2012 Final Research Report
  • [Presentation] Post-operative endophthalmitis2011

    • Author(s)
      Shizuya Saika
    • Organizer
      Pathology and treatment University of California Irvine.
    • Place of Presentation
      Los Angeles
    • Related Report
      2012 Final Research Report
  • [Presentation] Epithelial-mesenchymal transition as a therapeutic target in ocular fibrotic diseases.2011

    • Author(s)
      Shizuya Saika
    • Organizer
      University of California Irvine
    • Place of Presentation
      Los Angeles
    • Related Report
      2012 Final Research Report
  • [Presentation] 眼組織の透明治癒をめざして2011

    • Author(s)
      雑賀 司珠也
    • Organizer
      南燈会講演会
    • Place of Presentation
      和歌山
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] 薬剤性角膜上皮障害とその周辺2010

    • Author(s)
      雑賀司珠也
    • Organizer
      第3回北大阪眼科フォーラム
    • Place of Presentation
      大阪
    • Year and Date
      2010-11-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] 糖尿病網膜症、とくに黄斑浮腫の治療2010

    • Author(s)
      雑賀司珠也
    • Organizer
      日医生涯教育講座
    • Place of Presentation
      和歌山
    • Year and Date
      2010-09-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] 上皮-間葉系移行:線維化疾患の治療標的2010

    • Author(s)
      雑賀 司珠也
    • Organizer
      北大遺制研セミナー
    • Place of Presentation
      札幌
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] 上皮-間葉系移行と眼疾患2010

    • Author(s)
      雑賀 司珠也
    • Organizer
      関西眼疾患研究会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] 薬剤性角膜上皮障害

    • Author(s)
      雑賀司珠也
    • Organizer
      第6回山形Visual Science 研究会
    • Place of Presentation
      山形
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 薬剤性角膜上皮障害とその周辺

    • Author(s)
      雑賀司珠也
    • Organizer
      第12回眼科生体防御研究会
    • Place of Presentation
      島根
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 緑内障点眼薬と眼表面

    • Author(s)
      雑賀司珠也
    • Organizer
      2013年水虹会総会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
    • Invited

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Published: 2010-08-23   Modified: 2019-07-29  

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