The effect of Hydrogen gas in irrigating solution in ophthalmic surgery

• Project/Area Number: 22591952
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Nippon Medical School
• Principal Investigator: TAKAHASHI Hiroshi 日本医科大学, 大学院・医学研究科, 大学院教授 (00188046)
• Co-Investigator(Kenkyū-buntansha): OHARAZAWA Hideaki 日本医科大学, 医学部, その他 (20350035) ; IGARASHI Tutomu 日本医科大学, 医学部, 講師 (10421190)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 眼細胞生物学 / 酸化ストレス / 水素ガス / 網膜障害 / 細胞・組織 / 病理学 / 生理学 / 眼科学

Research Abstract

The anti-oxidative effect of irrigating solution containing hydrogen gas in the ophthalmic surgery was investigated. The effect was not clearly shown in phacoemulsification, while the protective influence was found in the vitro-retinal surgery.

Research Products

• [Journal Article] Direct comparison of the administration routesfor AAV8-mediated ocular gene therapy (2013)
  • Author(s): Igarashi T, Miyake K, Asakawa N, Miyake N, Shimada T, Takahashi H
  • Journal Title: Curr Eye Res Pages: 569-77
  • Peer Reviewed
• [Journal Article] Simultaneous treatment of pterygium and temporalconjunctivochalasis (2013)
  • Author(s): Suzuki H, Shiwa T, Oharazawa H, Igarashi T,Takahashi H.
  • Journal Title: Journal of Nippon Medical School Pages: 74-77
  • Peer Reviewed
• [Journal Article] Mometasone Furoate Nasal Spray Relieves the Ocular Symptoms of Seasonal Allergic Rhinoconjunctivitis (2013)
  • Author(s): Igarashi T, Nakazato Y, Kunishige T, Fujita M, Yamada Y, Fujimoto C, Okubo K, Takahashi H
  • Journal Title: Journal of Nippon Medical School Volume: 182-189
  • NAID: 130004147162
  • Peer Reviewed
• [Journal Article] Direct comparison of the administration routes for AAV8-mediated ocular gene therapy. (2013)
  • Author(s): Igarashi T, Miyake K, Asakawa N, Miyake N, Shimada T, Takahashi T
  • Journal Title: Current eye research Volume: in press Pages: 0-0
  • Peer Reviewed
• [Journal Article] Simultaneous treatment of pterygium and temporal conjunctivochalasis. (2013)
  • Author(s): Suzuki H, Shiwa T, Oharazawa H, Igarashi T, Takahashi H.
  • Journal Title: Journal of Nippon Medical School. Volume: 80 Pages: 74-77
  • NAID: 130004147209
  • Peer Reviewed
• [Journal Article] A new mutation in RP1L1 gene in occult macular dystrophy patient associated with a depolarizingpattern of focal macular ERG (2012)
  • Author(s): Kabuto T, Takahashi H, Goto-Fukuura Y, Igarashi T, Akahori M, Kameya S, Iwata T, Mizota A, Yamaki K, Miyake Y, Takahashi H.
  • Journal Title: Molecular Vision Pages: 1031-9
  • Peer Reviewed
• [Journal Article] Rapid and Transient Upregulation of CCL11 (Eotaxin-1) in Mouse Ovary During Terminal Stages of Follicular Development. (2012)
  • Author(s): Kuwabara Y, Katayama A, Igarashi T, Tomiyama R, Piao H, Kaneko R, Abe T, Mine K, Akira S, Orimo H, Takeshita T.
  • Journal Title: Am J Reprod Immunol. Volume: 67 Pages: 358-68
  • Peer Reviewed
• [Journal Article] A case of juvenile Sjögren’s syndrome with interstitial nephritis. (2012)
  • Author(s): Igarashi T, Itoh Y, Shimizu A, Igarashi T, Yoshizaki K, Fukunaga Y.
  • Journal Title: Journal of Nippon Medical School Volume: 79 Pages: 286-90
  • NAID: 130004147180
  • Peer Reviewed
• [Journal Article] A new mutation in RP1L1 gene in occult macular dystrophy patient associated with a depolarizing-pattern of focal macular ERG. (2012)
  • Author(s): Kabuto T, Takahashi H, Goto-Fukuura Y, Igarashi T, Akahori M, Kameya S, Iwata T, Mizota A, Yamaki K, Miyake Y, Takahashi H.
  • Journal Title: Molecular Vision. Volume: 18 Pages: 1031-9
  • Peer Reviewed
• [Journal Article] Mean hemoglobin levels in venous blood samples and prevalence of anemia in Japanese elementary and junior high school students. (2012)
  • Author(s): Igarashi T, Itoh Y, Maeda M, Igarashi T, Fukunaga Y.
  • Journal Title: Journal of Nippon Medical School. Volume: 79 Pages: 232-235
  • NAID: 130004147171
  • Peer Reviewed
• [Journal Article] Mometasone Furoate Nasal Spray Relieves the Ocular Symptoms of Seasonal Allergic Rhinoconjunctivitis.
  • Author(s): Igarashi T, Nakazato Y, Kunishige T, Fujita M, Yamada Y, Fujimoto C, Okubo K, Takahashi H.
  • Journal Title: Journal of Nippon Medical School Volume: 79 Pages: 182-189
  • NAID: 130004147162
  • Peer Reviewed
• [Presentation] 老視治療としての水晶体再建術における眼内レンズの現在と今後の展望 (2013)
  • Author(s): 鈴木久晴、稲毛道憲、志和利彦、高橋浩
  • Organizer: 第4回先進医療フォーラム
  • Place of Presentation: 東京
• [Presentation] EllipsFX(AMO)を用いた超音波乳化吸引における切開創の温度と前房温度の検討 (2012)
  • Author(s): 鈴木久晴、大木孝太郎、志和利彦、高橋浩
  • Organizer: 第27回日本眼内レンズ学会
• [Presentation] Antiseptic Effect of Ozonated Solution During Cataract Surgery (2012)
  • Author(s): Tomoyuki Kunishige, Hisaharu Suzuki, Toshihiko Shiwa, Hiroshi Takahashi
  • Organizer: ASCRS
• [Presentation] Semicircle-shaped capsulotomy marker (2012)
  • Author(s): Hisaharu Suzuki, Toshihiko Shiwa, HideakiOharazawa, Hiroshi Takahashi
  • Organizer: ASCRS
• [Presentation] EllipsFX(AMO)による虹彩色素脱出を予防するための曲り超音波チップの効果 (2012)
  • Author(s): 鈴木久晴、坂西京子、稲毛道憲、志和利彦、高橋浩
  • Organizer: 第66回日本臨床眼科学会
• [Presentation] 老視治療としての水晶体再建術における眼内レンズの現在と今後の展望 (2012)
  • Author(s): 鈴木久晴、稲毛道憲、志和利彦、高橋浩
  • Organizer: 第4回先進医療フォーラム
• [Presentation] 異なる投与法によるAAVtype8ベクターの遺伝子導入効率と安全性の比較検討 (2012)
  • Author(s): 五十嵐勉、三宅弘一、浅川なぎさ、三宅紀子、島田隆、高橋浩
  • Organizer: 第51回日本網膜硝子体学会
• [Presentation] 角膜移植後の免疫寛容における Tim-3 / Gal-9 経路の抑制的役割 (2012)
  • Author(s): 榛村真智子、堀 純子、王明聡、谷口ヒロ子、高橋浩、梯彰弘、 秋葉久弥、八木田秀雄
  • Organizer: 第 46 回日本眼炎症学会
  • Place of Presentation: 横浜
• [Presentation] マイトマイシンC併用線維柱帯切除術後眼の長期眼圧変動 (2012)
  • Author(s): 中元兼二、高橋 浩
  • Organizer: 第23回日本緑内障学会
  • Place of Presentation: 金沢
• [Presentation] Semicircle-shaped capsulotomy marker (2012)
  • Author(s): Hisaharu Suzuki, Toshihiko Shiwa, Hideaki Oharazawa, Hiroshi Takahashi
  • Organizer: ASCRS
  • Place of Presentation: シカゴ
• [Presentation] Ellips FX（AMO）を用いた超音波乳化吸引における切開創の温度と前房温度の検討 (2012)
  • Author(s): 鈴木久晴、大木考太郎、志和利彦、高橋浩
  • Organizer: 第27回JSCRS
  • Place of Presentation: 東京
• [Presentation] 白内障手術中におけるオゾン水点眼の消毒効果 (2012)
  • Author(s): 國重智之、鈴木久晴、芹澤元子、志和利彦、高橋浩
  • Organizer: 第27回JSCRS
  • Place of Presentation: 東京
• [Presentation] Semicircle-shaped capsulotomy marker (2012)
  • Author(s): Hisaharu Suzuki, Toshihiko Shiwa, Hideaki Oharazawa, Hiroshi Takahashi
  • Organizer: ESCRS
  • Place of Presentation: ミラノ
• [Presentation] Ellips FX（AMO)による虹彩色素脱出を予防するための曲り超音波チップの効果 (2012)
  • Author(s): 鈴木久晴、坂西京子、稲毛道憲、志和利彦、高橋浩
  • Organizer: 第66回日本臨床眼科学会
  • Place of Presentation: 京都
• [Book] 眼科 (2012)
  • Author(s): 高橋 浩
  • Publisher: 金原出版