Structural and Functional Evaluation of Blood-Ocular-Barrier
| Project/Area Number |
22591953
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Aichi Medical University |
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Principal Investigator |
ZAKO Masahiro 愛知医科大学, 医学部, 教授 (80298596)
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| Co-Investigator(Kenkyū-buntansha) |
YONEDA Masahiko 愛知県立看護大学, 看護学部, 教授 (80201086)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 血液房水関門 / ぶどう膜炎 / 腫瘍壊死因子 / 抗腫瘍壊死因子抗体 / マトリックスメタ ロプロテアーゼ(MMP) / ベーチェット病 / TNF-α / infliximab / マトリックスメタロプロテアーゼ / 毛様体無色素上皮細胞 / 血液眼関門 / 血液網膜関門 / 網膜色素上皮細胞 / 網膜血管内皮細胞 / MMP / TIMP / 細胞外マトリックス |
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| Research Abstract |
Induction of matrix metalloproteinases (MMPs) in non-pigmented ciliary epithelium (HNPCECs) by tumor necrosis factor-alpha (TNF-α) was counteracted by infliximab. Immunostaining showed that the MMPs degraded claudin-1 and occludin, major components of the tight junctions in the blood-aqueous barrier, in HNPCECs and in non-pigmented ciliary epithelial cells of the swine ciliary body.
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Report
(4 results)
Research Products
(15 results)
