| Project/Area Number |
22591964
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Okayama University |
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Principal Investigator |
OHTSUKI Hiroshi 岡山大学, 大学院・医歯薬学総合研究科, 教授 (70093672)
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| Co-Investigator(Kenkyū-buntansha) |
MIYATA Manabu 岡山大学, 岡山大学病院, 助教 (00548505)
KONO Reika 岡山大学, 医学部, 客員研究員 (40301296)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 上斜筋麻痺 / 遺伝子多型 / 表現型 / 高解像度MRI / 眼窩プリー / Listing平面 / 眼球反対回旋 / 眼窩MRI撮影 / 上斜筋低形成 / ARIX遺伝子 / PHOX2B遺伝子 / 立体感覚 / 斜筋手術 / Bielschowsky頭部傾斜試験 / 高解像度MRI撮像 |
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| Research Abstract |
Patients with ARIX and/or PHOX2B polymorphisms had significantly greater paretic-side/normal-side ratios of the muscle compared with patients without the polymorphisms. Superior oblique muscle atrophy could be defined quantitatively as a ratio of 0.75 or less. Approximately 50% of patients exhibited superior oblique atrophy in the MRI images. The effect of oblique muscle surgery on rectus muscle pulleys was the amount ocular torsion, not the difference in surgical procedure induced by oblique muscle surgery. The wide range of difference in orientation of Listing plane can be measured with a Synoptometer, and can differentiate superior oblique muscle palsy into 2 types. Hyperdeviation between ipsilesional head tilt and the upright position can be explained by decreased compensatory ocular counterrolling due to the decreased torque of the paretic superior oblique muscle.
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