| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
We analyzed the proliferative capacity of Muller glia in rodent models of photoreceptor damage. No proliferation was observed in the mouse retina whereas almost all Muller glia reentered the cell cycle in the rat retina; however, rat Mullerglia underwent the DNA damage response and p53 activation, leading to cell death. Thus, the DNA damage response in Muller glia may be one of the mechanisms underlying the limitedregenerative capacity of the mammalian retina
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