| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Research Abstract |
In this study, using experimental allergic conjunctivitis mouse model, we have showed that EP3, a subtype of PGE2 receptors, was dominantly expressed in ocular surface epithelium, and that it could suppress the ocular surface inflammation and might contribute the homeostasis of ocular surface. Moreover, we have also showed that EP3 was dominantly expressed in human ocular surface epithelium, and that in the conjunctival epithelium of human ocular surface inflammatory disease such as Stevens-Johnson syndrome and cicatricial ocular pemphigoid, the expression of EP3 were remarkably down-regulated. Our findings suggest that PG receptors might contribute in human ocular surface diseases.
|
