Analysis of mechanisms of the inflammation regulated by receptors of prostaglandins in ocular surface epithelial cells
| Project/Area Number |
22591971
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Doshisha University |
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Principal Investigator |
UETA Mayumi 同志社大学, 生命医科学部, 准教授 (60398386)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 眼免疫学 / 眼表面上皮細胞 / プロスタグランジン / アレルギー / 炎症 / 眼表面上皮 |
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| Research Abstract |
In this study, using experimental allergic conjunctivitis mouse model, we have showed that EP3, a subtype of PGE2 receptors, was dominantly expressed in ocular surface epithelium, and that it could suppress the ocular surface inflammation and might contribute the homeostasis of ocular surface. Moreover, we have also showed that EP3 was dominantly expressed in human ocular surface epithelium, and that in the conjunctival epithelium of human ocular surface inflammatory disease such as Stevens-Johnson syndrome and cicatricial ocular pemphigoid, the expression of EP3 were remarkably down-regulated. Our findings suggest that PG receptors might contribute in human ocular surface diseases.
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Report
(4 results)
Research Products
(79 results)
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[Journal Article] Epistatic interaction between Toll-like receptor 3 (TLR3) and prostaglandin E receptor 3 (PTGER3) genes2012
Author(s)
Ueta M, Tamiya G, Tokunaga K, Sotozono C, Ueki M, Sawai H, Inatomi T, Matsuoka T, Akira S, Narumiya S, Tashiro K, Kinoshita S
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Journal Title
J Allergy Clin Immunol.
Volume: 129(5)
Pages: 1413-1416
Related Report
Peer Reviewed
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[Journal Article] Epistatic interaction between Toll-like receptor 3 (TLR3) and prostaglandin E receptor 3 (PTGER3) genes2012
Author(s)
Ueta M, Tamiya G, Tokunaga K, Sotozono C, Ueki M, Sawai H, Inatomi T, Matsuoka T, Akira S, Narumiya S, Tashiro K, Kinoshita S
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Journal Title
J Allergy Clin Immunol Peer-Reviewed papers
Volume: 129(5)
Issue: 5
Pages: 1413-1416
DOI
Related Report
Peer Reviewed
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[Journal Article] Association between prostaglandin E receptor 3 polymorphisms and Stevens-Johnson syndrome identified by means of a genome-wide association study2010
Author(s)
Ueta M, Sotozono C, Nakano M, Taniguchi T, Yagi T, Tokuda Y, Fuwa M, Inatomi T, Yokoi N, Tashiro K, Kinoshita S
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Journal Title
J Allergy Clin Immunol
Volume: 126(6)
Pages: 1218-1225
Related Report
Peer Reviewed
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[Presentation] Epistatic interaction between TLR3 and PTGER3 confers an increased risk for Stevens-Johnson syndrome with ocular complications2012
Author(s)
Ueta M, Tamiya G, Tokunaga K, Sotozono C, Ueki M,Sawai H, Inatomi T, Matsuoka T, Akira S, Narumiya S, Kinoshita S
Organizer
2012 Gordon Research Conference:Biology & Pathobiology of the Cornea
Place of Presentation
Ventura, California, USA
Year and Date
2012-03-28
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[Presentation] FP localization and expression in ocular tissue2011
Author(s)
Imai K, Ueta M, Mori K, Ikeda Y, Ueno M, Yokoi N, Koga T, Narumiya S, Kinoshita S
Organizer
2011 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO)
Place of Presentation
Fort Lauderdale, Florida, USA
Year and Date
2011-05-04
Related Report
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[Presentation] FP localization and expression in ocular tissue2011
Author(s)
Imai K, Ueta M, Mori K, Ikeda Y, Ueno M, Yokoi N, Koga T, Narumiya S, Kinoshita S
Organizer
2011 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO)
Place of Presentation
Broward County Convention Center (Florida, USA)
Year and Date
2011-05-04
Related Report
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[Presentation] Stevens-Johnson症候群に対する全遺伝子アプローチによる遺伝子多型解析2010
Author(s)
木下茂, 上田真由美, 外園千恵, 稲富勉, 横井則彦, 中野正和, 谷口孝純, 八木知人, 徳田雄市, 不破正博, 田代啓
Organizer
第31回日本炎症・再生医学会
Place of Presentation
東京
Year and Date
2010-08-05
Related Report
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[Presentation] Association between prostaglandin E receptor 3 polymorphisms and Stevens-Johnson syndrome with ocular involvement identified by genome-wide association study in a Japanese population2010
Author(s)
Ueta M, Sotozono C, Nakano M, Taniguchi T, Yagi T, Tokuda Y, Fuwa M, Inatomi T, Yokoi N, Tashiro K, Kinoshita S
Organizer
Keystone Symposia, Bioactive Lipids, Biochemistry and Diseases
Place of Presentation
Kyoto, JAPAN
Year and Date
2010-06-09
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