| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Research Abstract |
We aimed to identify small molecules that can induce neuronal cell differentiation. As the results, we show that 1) the p38 MAPK-specific inhibitor SB203580 blocks the spontaneous differentiation of ES cells into cardiomyocytes, and instead induces the differentiation of these ES cells into neurons 2) p38 regulates BMP2 gene expression through the transcription factor MEF2C, and 3) JNK signaling pathway regulates axon elongation. Furthermore, 4) we screened 1,600 well-characterized small molecule compounds and identified about 20 drugs that stimulate neuronal differentiation.
|
