| Project/Area Number |
22591976
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | Chiba University |
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Principal Investigator |
YOSHIDA Hideo 千葉大学, 大学院・医学研究院, 教授 (60210712)
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| Co-Investigator(Kenkyū-buntansha) |
HISHIKI Tomoro 千葉大学, 大学院・医学研究院, 講師 (00375776)
KAMIJO Takehiko 千葉県がんセンター(研究所), 発がん研究グループ, 部長 (90262708)
SHIRASAWA Hiroshi 千葉大学, 大学院・医学研究院, 教授 (00216194)
SAITO Takeshi 千葉大学, 大学院・医学研究院, 講師 (20406044)
佐藤 嘉治 千葉大学, 医学部附属病院, 助教 (60375772)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 神経芽腫 / 腫瘍融解ウイルス / がん幹細胞 / ヘルペスウイルス１型 / 癌幹細胞 / sphere形成細胞 / 抗癌剤耐性 |
|---|
| Research Abstract |
Cancer stem cells have potentials of self-renewal and differentiate. Cancer stem cell-like cells could be extracted through the sphere culture method. Neuroblastoma cell line IMR32 and sIMR32 (cells extracted through sphere culture) were compared for chemosensitivity. IMR32 were more susceptible to cisplatin treatment. However, there was no difference in the cytotoxicity by HSV-1.
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