Development of minimally invasive treatment for severe tracheomalacia using drug delivery system and growth factors

• Project/Area Number: 22591977
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatric surgery
• Research Institution: The University of Tokyo
• Principal Investigator: SUGIYAMA Masahiko 東京大学, 医学部附属病院, 講師 (00270877)
• Co-Investigator(Kenkyū-buntansha): KOMURA Makoto 埼玉医科大学, 医学部, 教授 (10422289) ; TABATA Yasuhiko 京都大学, 再生医科学研究所, 教授 (50211371)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 気管軟化症 / 成長因子 / ドラッグデリバリーシステム / 小児

Research Abstract

This study showed that slowly released b-FGF enlarges the tracheal lumen and thickens the cartilage dose-dependently. Symptoms of tracheomalacia usually improve with age. Rapid growth of tracheal cartilage inducedby slowly released b-FGF could possibly act as a novel treatment for tracheaomalacia.

Research Products

• [Journal Article] Slow release of basic fibroblast growth factor (b-FGF) promotes growth of tracheal cartilage. (2013)
  • Author(s): Ishimaru T, Komura M, Sugiyama M, Tabata Y.
  • Journal Title: J Pediatr Surg Volume: 48(2) Pages: 288-92
  • Peer Reviewed
• [Journal Article] Slow Release of Basic Fibroblast Growth Factor (b-FGF) Promotes Growth of Tracheal Cartilage (2013)
  • Author(s): Ishimaru T
  • Journal Title: Journal of Pediatric Suregery Volume: 48 Issue: 2 Pages: 288-292
  • DOI: 10.1016/j.jpedsurg.2012.11.003
  • Peer Reviewed
• [Presentation] b-FGF徐放による気管の成長促進 重症気管軟化症に対する新治療法開発 (2013)
  • Author(s): 石丸哲也,古村眞,杉山正彦,田畑泰彦
  • Organizer: 横浜
  • Year and Date: 2013-03-23
• [Presentation] b-FGF徐放による気管の成長促進 重症気管軟化症に対する新治療法開発 (2013)
  • Author(s): 石丸哲也
  • Organizer: 第12回 日本再生医療学会
  • Place of Presentation: 横浜
• [Presentation] Slow Release of Basic Fibroblast Growth Factor (b-FGF) Promotes Growth of Tracheal Cartilage (2012)
  • Author(s): Ishimaru T, Komura M, Masahiko Sugiyama M, Tabata Y
  • Organizer: EUPSA/BAPS joint meeting 2012
  • Place of Presentation: Rome, Italy
  • Year and Date: 2012-06-14