| Project/Area Number |
22591978
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | Kinki University (2012)
Osaka University (2010-2011) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
USUI Noriaki 大阪大学, 医学系研究科, 准教授 (30273626)
TANI Gakuto 大阪大学, 医学部附属病院, 医員 (60467561)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 再生医療 / 機能的層構造 / 気管軟骨 / 細胞積層化 / 細胞シート工学 / Tissue engineering / Cylindrical cartilage / 回転培養 |
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| Research Abstract |
Auricular chondrocytes were harvested from rabbits and cultivated to form a chondrocyte sheet. We manufactured cylindrical cartilage structure from the sheet by the in vitro roller tube culture. Furthermore, we made the fibroblast layer sheet and column cilia epithelial layer sheet with the different function that varied in each. We tried laminating these three kinds of seats (We placed column cilia epithelial layers, a cartilage cell layer and the fibroblast layer sequentially from the inside), and tried to manufacture cylindrical functional structure, however resulted in failure of regeneration. If tracheal regeneration having functional laminar structure is enabled by this method, a new therapy for pediatric airway disease will be developed using the regeneration trachea.
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