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Molecular biological resolution of hindgut embryogenesis with a rescue program for anorectal malformations induced by retinoic acid in mice

Research Project

Project/Area Number 22591982
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatric surgery
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

SASAKI Yasunari  京都府立医科大学, 医学(系)研究科(研究院), 客員講師 (30405253)

Co-Investigator(Kenkyū-buntansha) ONO Shigeru  自治医科大学, 医学部, 准教授 (00315962)
岩井 直躬  明治国際医療大学, 教授 (90128695)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords先天性消化器疾患学 / 直腸肛門奇形 / 遺伝的組織系譜解析 / 発生分化 / シグナル伝達 / 発現制御 / 発生・分化
Research Abstract

In the embryos administered ATRA only, over 95% demonstrated ARM. In the embryos administered both ATRA and LE135, however, 44% of the embryos demonstrated normal development of the rectum and anus. Therefore, these findings indicate that RA receptor antagonist prevents disturbance of the cell signaling pathway between the epithelium and the mesenchyme layers because RA receptor antagonist inhibits RA receptor from forming heterodimers with retinoid X receptors.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (21 results)

All 2012 2011 2010 Other

All Journal Article (13 results) (of which Peer Reviewed: 5 results) Presentation (8 results)

  • [Journal Article] Hirschsprung 病の標準的診断法について2011

    • Author(s)
      佐々木康成、津田知樹、古川泰三、 小野 滋、木村 修、岩井直躬
    • Journal Title

      小児外科

      Volume: 43(6) Pages: 623-626

    • Related Report
      2012 Final Research Report
  • [Journal Article] 直腸内に大きな便塊が形成2011

    • Author(s)
      佐々木康成、岩井直躬、古川泰三、 小野 滋、木村 修
    • Journal Title

      小児外科

      Volume: 43(7) Pages: 781-784

    • Related Report
      2012 Final Research Report
  • [Journal Article] 慢性便秘2011

    • Author(s)
      佐々木康成、岩井直躬、木村 修、 小野 滋、古川泰三
    • Journal Title

      小児外科

      Volume: 43(8) Pages: 876-877

    • Related Report
      2012 Final Research Report
  • [Journal Article] Establishment of a rescue program for anorectal malformations induced by retinoic acid in mice2011

    • Author(s)
      Yasunari Sasaki, Naomi Iwai, Osamu Kimura, Shigeru Ono, Tomoki Tsuda
    • Journal Title

      J Pediatr Surg

      Volume: 46(7) Pages: 1396-1399

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] PCSK5 and GDF11 Expression in the Hindgut Region of Mouse Embryos with Anorectal Malformations2011

    • Author(s)
      T. Tsuda, N. Iwai, E. Deguchi, O. Kimura, S. Ono, T. Furukawa, Y. Sasaki, S. Fumino, Y. Kubota
    • Journal Title

      Eur J Pediatr Surg

      Volume: 21 (4) Pages: 238-241

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hirschsprung病の標準的診断法について2011

    • Author(s)
      佐々木康成
    • Journal Title

      小児外科

      Volume: 43 Pages: 623-626

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 慢性便秘2011

    • Author(s)
      佐々木康成
    • Journal Title

      小児外科

      Volume: 43 Pages: 876-877

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Establishment of a rescue program for anorectal malformations induced by retinoic acid in mice.2011

    • Author(s)
      Sasaki Y, Iwai N, Kimura O
    • Journal Title

      Journal of Pediatric Surgery

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 遺伝的組織系譜解析2010

    • Author(s)
      佐々木康成、岩井直躬、木村 修、 小野 滋、津田知樹
    • Journal Title

      小児外科

      Volume: 42(7)

    • Related Report
      2012 Final Research Report
  • [Journal Article] 直腸肛門奇形術後の長期フォローアップ‐20歳以上‐2010

    • Author(s)
      岩井直躬、佐々木康成、出口英一、岩田譲司、木村 修、久保田良浩、深田良一、小野 滋
    • Journal Title

      周産期医学

      Volume: 40(8) Pages: 1245-1249

    • Related Report
      2012 Final Research Report
  • [Journal Article] 腹会陰式直腸肛門形成術術後成人例における QOL2010

    • Author(s)
      津田知樹、岩井直躬、木村 修、 小野 滋、古川泰三、佐々木康成、出口英一、久保田良浩
    • Journal Title

      小児外科

      Volume: 42(11) Pages: 1201-1204

    • Related Report
      2012 Final Research Report
  • [Journal Article] Long-term outcomes after hepaticojejunostomy for choledochal cyst : a 10- to 27- year follow up2010

    • Author(s)
      Ono S, Fumino S, Iwai N
    • Journal Title

      Journal of Pediatric Surgery

      Volume: 45 Pages: 376-378

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Laparoscopic versus open abdominoperineal rectoplasty for infants with high-type anorectal malformation.2010

    • Author(s)
      Kimura O, Iwai N, Sasaki Y
    • Journal Title

      Journal of Pediatric Surgery

      Volume: 45 Pages: 2390-2393

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 直腸肛門奇形術後成人例における性・生殖機能の問題2012

    • Author(s)
      佐々木康成、木村 修、 小野 滋、古川泰三、文野誠久、岩井直躬
    • Organizer
      第112回日本外科学会定期学術集会
    • Place of Presentation
      千葉
    • Year and Date
      2012-04-13
    • Related Report
      2012 Final Research Report
  • [Presentation] Hirschsprung 病の術式からみた術後排便機能評価2011

    • Author(s)
      佐々木康成、木村 修、 小野 滋、古川泰三、文野誠久、岩井直躬
    • Organizer
      第48回日本小児外科学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-07-21
    • Related Report
      2012 Final Research Report
  • [Presentation] Hirschsprung病の術式からみた術後排便機能評価2011

    • Author(s)
      佐々木康成
    • Organizer
      第48回日本小児外科学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-07-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Establishment of a rescue program for anorectal malformations induced by retinoic acid in mice.2010

    • Author(s)
      Sasaki Y, Iwai N, Kimura O
    • Organizer
      第57回英国小児外科学会
    • Place of Presentation
      アバディーン(英国)
    • Year and Date
      2010-07-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] Establishment of a rescue program for anorectal malformations induced by retinoic acid in mice2010

    • Author(s)
      Y. Sasaki, N. Iwai, O. Kimura, S. Ono, T. Tsuda, T. Tanaka
    • Organizer
      British Association of Pediatric Surgeons 57th Annual International Congress
    • Place of Presentation
      Aberdeen UK
    • Related Report
      2012 Final Research Report
  • [Presentation] PCSK5 and GDF expression in the hindgut region of mouse embryo with anorectal malformations2010

    • Author(s)
      T. Tsuda, N. Iwai, O. Kimura, S. Ono, Y. Sasaki, S. Fumino
    • Organizer
      British Association of Pediatric Surgeons 57th Annual International Congress
    • Place of Presentation
      Aberdeen UK
    • Related Report
      2012 Final Research Report
  • [Presentation] Laparoscopic vs. open Abdominoperineal anorectoplasty for infants with the high type of anorectal malformation2010

    • Author(s)
      O. Kimura, N. Iwai, Y. Sasaki, T. Tsuda, E. Deguchi, S. Ono, T. Furukawa, S. Fumino
    • Organizer
      43rd Annual Meeting of Pacific Association of Pediatric Surgeons
    • Place of Presentation
      Kobe, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] 直腸肛門奇形術後成人例における性・生殖機能の問題

    • Author(s)
      佐々木康成
    • Organizer
      第112回日本外科学会定期学術集会
    • Place of Presentation
      ホテルニューオータニ幕張
    • Related Report
      2012 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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