| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
The identification and analysis of hepatoblastoma Cancer stem cells（CSCs） can be significantly challenging in elucidating the carcinogenic mechanism of childhood cancerand developing a prognosis for a new therapy. CSCs in hepatoblastoma cells were separated,and these cells were identified in an in vivo experiment into mice. We also examined distribution of CD133 in a human hepatoblastoma cell-line. The results suggest that CD133 membrane localization plays a role in tumor cell adhesion and migration. Furthermore, the findings imply that CD133 is involved in tumor angiogenesis.
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