Functional analysis of specific activation factor and elucidation of the tumorangiogenesis in hepatoblastoma stem cells
| Project/Area Number |
22591985
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | Saitama Medical University |
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Principal Investigator |
FUJITA Keiko 埼玉医科大学, 医学部, 准教授 (80173425)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 肝芽腫 / 癌幹細胞 / 培養 / CD133 / 腫瘍血管 / 血管新生 / 癌 / 小児癌 / side popul ation / CD44 |
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| Research Abstract |
The identification and analysis of hepatoblastoma Cancer stem cells（CSCs） can be significantly challenging in elucidating the carcinogenic mechanism of childhood cancerand developing a prognosis for a new therapy. CSCs in hepatoblastoma cells were separated,and these cells were identified in an in vivo experiment into mice. We also examined distribution of CD133 in a human hepatoblastoma cell-line. The results suggest that CD133 membrane localization plays a role in tumor cell adhesion and migration. Furthermore, the findings imply that CD133 is involved in tumor angiogenesis.
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Report
(4 results)
Research Products
(15 results)
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[Presentation] ヒト肝芽腫細胞株における癌幹細胞の特徴2011
Author(s)
藤田恵子、林信一、里見昭、松本幸子、大島晋、穐田真澄、永島雅文
Organizer
第88回 日本生理学会大会/第116回日本解剖学会総会・全国学術集会合同大会
Place of Presentation
東北地方太平洋沖地震のため集会は中止し、Journal of Physiological Science 誌上開催
Related Report
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