| Project/Area Number |
22591991
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | Osaka University |
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Principal Investigator |
HOSOKAWA Ko 大阪大学, 医学系研究科, 教授 (20181498)
|
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| Co-Investigator(Kenkyū-buntansha) |
SAKAI Yasuo 大阪大学, 医学系研究科, 准教授 (50272315)
MATSUDA Ken 大阪大学, 医学系研究科, 助教 (50423166)
KIKUCHI Mamoru 大阪大学, 医学系研究科, 助教 (20437677)
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | レチノイン酸 / 骨発生 / 軟骨発生 / 頭蓋顔面骨 / CYP26 / 軟骨形成 / 骨形成 / 再生医療 / CYP26B1 |
|---|
| Research Abstract |
We analyzed the CYP26B1 conditional knockout mice driven by cartilage precursor specific Cre. The mice were normally born, but revealed severe growth impairment at three or four weeks after birth. The facial bone was rounder and smaller in shape, including the deficiency of dental occlusion caused by the imbalance between the maxilla and the mandible. The decrease of chondrocytes in the growth plate resembled a phenotype of complications induced by retinoid therapy, which was thought to be clinically important.
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