Horizontal bony outgrowth for mandibular bone using tissue engineering technology

• Project/Area Number: 22592005
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Plastic surgery
• Research Institution: Nippon Medical School
• Principal Investigator: HYAKUSOKU Hiko 日本医科大学, 医学研究科, 教授 (00165135)
• Co-Investigator(Kenkyū-buntansha): MIZUNO Hiroshi 順天堂大学, 医学部, 教授 (80343606)
• Co-Investigator(Renkei-kenkyūsha): TOBITA Morikuni 順天堂大学, 医学部, 助教 (10599038)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 脂肪組織幹細胞 / 骨増生 / 多血小板血漿 / β-TCP / α-TCP / 頭蓋骨欠損モデル / 水平性骨吸収 / 顎骨

Research Abstract

The purpose of this study is to establish the method for bony outgrowth on the original bone with the combination of adipose-derived stem cells (ASCs), platelet-rich plasma (PRP) and the compression molding tri-calcium phosphate (TCP). The implantation of ASCs/PRP and the compression molding α-TCP scaffold might be having a potential for the bony outgrowth method.

Research Products

• [Journal Article] Adipose-derived stem cells as a novel tool for future regenerative medicine (2012)
  • Author(s): Mizuno H, Tobita M, Uysal AC
  • Journal Title: Stem Cells Volume: 30 Pages: 804-810
  • Peer Reviewed
• [Journal Article] Adipose-derived stem cells as a novel tool for future regenerative medicine (2012)
  • Author(s): Mizuno H, Tobita M, Uysal AC
  • Journal Title: Stem Cells Volume: 30 Issue: 5 Pages: 804-810
  • DOI: 10.1002/stem.1076
  • Peer Reviewed
• [Journal Article] Effects of adipose-derived stem cells on improving the viability of diced cartilage grafts (2012)
  • Author(s): Orbay H, et al
  • Journal Title: Plast Reconstr Surg Volume: 129 Pages: 369-77
  • Peer Reviewed
• [Journal Article] Adipose-derived stem cells: current findings and future perspectives (2011)
  • Author(s): Tobita M, Orbay H, Mizuno H
  • Journal Title: Discov Med Volume: 11 Pages: 160-170
  • Peer Reviewed
• [Journal Article] Effect of adipose-derived stem cells on improving the viability of diced cartilage graft (2011)
  • Author(s): Orbay H, Tobita M, Hyakusoku H, Mizuno H
  • Journal Title: Plast Reconstr Surg Volume: 129 Pages: 369-377
• [Journal Article] Adipose-derived stem cells : current findings and future perspectives (2011)
  • Author(s): Tobita M, et al
  • Journal Title: Discov Med Volume: 11 Pages: 160-70
  • Peer Reviewed
• [Journal Article] Periodontal Disease and Periodontal Tissue Regeneration (2010)
  • Author(s): Tobita M, Mizuno H
  • Journal Title: Curr Stem Cell Res Ther Pages: 168-174
  • Peer Reviewed
• [Journal Article] Adipose-derived stem and stromal cells for cell-based therapy : current status of preclinical studies and clinical trials. (2010)
  • Author(s): Mizuno H
  • Journal Title: Curr Opin Mol Ther. Volume: 12 Pages: 442-9
  • Peer Reviewed
• [Journal Article] Periodontal Disease and Periodontal Tissue Regeneration. (2010)
  • Author(s): Tobita, et al
  • Journal Title: Curr Stem Cell Res Ther. Volume: 5 Pages: 168-74
  • Peer Reviewed
• [Journal Article] Fat grafting to the breast and adipose-derived stem cells : recent scientific consensus and controversy. (2010)
  • Author(s): Mizuno, et al
  • Journal Title: Aesthet Surg J. Volume: 30 Pages: 381-7
  • Peer Reviewed
• [Presentation] ラット頭蓋骨における脂肪組織幹細胞と多血小板血漿による骨再生能の免疫学的検証 (2013)
  • Author(s): 田島聖士、飛田護邦、ハカンオルバイ、百束比古、水野博司
  • Organizer: 第12回日本再生医療学会総会
  • Place of Presentation: 神奈川・日本
  • Year and Date: 2013-03-21
• [Presentation] ラット頭蓋骨における脂肪組織幹細胞と多血小板血漿を用いた硬組織再生への効果 (2012)
  • Author(s): 飛田護邦、田島聖士、ハカンオルバイ、百束比古、水野博司
  • Organizer: 第42回日本創傷治癒学会
  • Place of Presentation: 北海道・日本
  • Year and Date: 2012-12-04
• [Presentation] 多血小板血漿を移植キャリアーとして用いた脂肪組織幹細胞の硬組織再生能 (2012)
  • Author(s): 飛田護邦、田島聖士、ハカンオルバイ、百束比古、水野博司
  • Organizer: 第4回PRP療法研究会
  • Place of Presentation: 大阪・日本
  • Year and Date: 2012-11-25
• [Presentation] ラット頭蓋骨における脂肪組織幹細胞と多血小板血漿を用いた硬組織再生への効果 (2012)
  • Author(s): 飛田護邦
  • Organizer: 第42回日本創傷治癒学会
  • Place of Presentation: 札幌
• [Presentation] The effect for bone regeneration with combination of adipose-derived stem cells and platelet-rich plasma (2012)
  • Author(s): Morikuni Tobita
  • Organizer: 10th Annual Meeting of the International Federation for Adipose Therapeutics and Science
  • Place of Presentation: Quebec
• [Presentation] 脂肪組織幹細胞と多血小板血漿によるラット頭蓋骨における骨再生能の検証 (2012)
  • Author(s): 田島聖士
  • Organizer: 第21回日本形成外科学会 基礎学術集会
  • Place of Presentation: 福島
• [Presentation] 形成外科領域における脂肪組織由来幹細胞を用いた再生医学の現状 (2011)
  • Author(s): 水野博司
  • Organizer: 第53回歯科基礎医学会
  • Place of Presentation: 岐阜・日本
  • Year and Date: 2011-10-02
• [Presentation] 形成外科領域における脂肪組織由来幹細胞を用いた再生医学の現状 (2011)
  • Author(s): 水野博司
  • Organizer: 第53回歯科基礎医学会
  • Place of Presentation: 長良川国際会議場
  • Year and Date: 2011-10-02
• [Presentation] Therapeutic strategy and future perspective using adipose-derived stem cells in regenerative medicine (2010)
  • Author(s): Mizuno H
  • Organizer: 3rd Annual World Congress of Regenerative Medicine and Stem Cells
  • Place of Presentation: Shanghai, Republic of China
  • Year and Date: 2010-12-06
• [Presentation] ラット頭蓋骨における脂肪組織幹細胞と多血小板血漿による骨再生能の免疫学的検証
  • Author(s): 田島聖士
  • Organizer: 第１2回日本再生医療学会総会
  • Place of Presentation: 横浜
• [Presentation] 多血小板血漿を移植キャリアーとして用いた脂肪組織幹細胞の硬組織再生能
  • Author(s): 飛田護邦
  • Organizer: 第4回PRP療法研究会
  • Place of Presentation: 大坂
• [Book] (分担)Adipose-derived stem cells for skin regeneration "Adipose-Derived Stem Cells : Methods and Protocols, Methods in Molecular Biology" (2010)
  • Author(s): Mizuno, et al
  • Total Pages: 7
  • Publisher: Springer, New York, NY
• [Remarks]
  • URL: http://web.me.com/nmsprs/lab/SCBTR_jp.html