Experimental study of the effectiveness of CO2 for the brain protection after cardiopulmonary arrest

• Project/Area Number: 22592008
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Gunma University
• Principal Investigator: OSHIMA Kiyohiro 群馬大学, 医学(系)研究科(研究院), 教授 (60361375)
• Co-Investigator(Kenkyū-buntansha): HAGIWARA Shuichi 群馬大学, 大学院医学系研究科, 助教 (20455992)
• Project Period (FY): 2010-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 心肺停止 / 心肺蘇生 / 脳保護 / 二酸化炭素 / 虚血再灌流傷害 / 自己心拍再開 / アニオンギャップ / アルブミン補正アニオンギャップ / 温阻血 / ATP感受性Kチャンネル

Research Abstract

WE reported the effectiveness of the introduction of percutaneous cardiopulmonary support system (PCPS) and hemodialysis in patients with cardiopulmonary arrest (CPA) due to accidental hypothermia. We aiso reported that anion gap (AG) and albumin-corrected AG (ACAG) were useful predictors of return of spontaneous circulation (ROSC) in patients with CPA. In addition, we evaluated the usefulness of fibrin degradation products (FDP) and D-dimer levels in blood to predict ROSC in patients with CPA compared with AG and ACAG.

Research Products

• [Journal Article] The significance of albumin corrected anion gap in patients with cardiopulmonary arrest (2013)
  • Author(s): Hagiwara S, Oshima K, Furukawa K, Nakamura T, Ohyama Y, Tamura J
  • Journal Title: Annals of Thoracic and Cardiovascular Surgery Volume: Vol.19, No.4 Pages: 283-288
  • NAID: 130002583824
  • Peer Reviewed
• [Journal Article] The Significance of Albumin Corrected Anion Gap in Patients with Cardiopulmonary Arrest (2013)
  • Author(s): Hagiwara S, Oshima K, Furukawa K, Nakamura T, Ohyama Y, Tamura J.
  • Journal Title: Annals of Thoracic and Cardiovascular Surgery Volume: 19 Issue: 4 Pages: 283-288
  • DOI: 10.5761/atcs.oa.12.01942
  • NAID: 130002583824
  • ISSN: 1341-1098, 2186-1005
  • Peer Reviewed
• [Journal Article] Usefulness of fibrin degradation products and d-dimer levels as biomarkers that reflect the severity of trauma (2013)
  • Author(s): Hagiwara S, Oshima K, Aoki M, Murata M, Ishihara K, Kaneko M, Furukawa K, Nakamura T, Ohyama Y, Tamura J.
  • Journal Title: The journal of trauma and acute care surgery Volume: 74 Issue: 5 Pages: 1275-1278
  • DOI: 10.1097/ta.0b013e31828cc967
  • Peer Reviewed
• [Journal Article] Septic shock caused by Klebsiella oxytoca: An autopsy case and a survival case with driving Extracorporeal Membrane Oxygenation (2013)
  • Author(s): Hagiwara S, Murata M, Aoki M, Kaneko M, Oshima K.
  • Journal Title: Hippokratia Volume: 17 Pages: 171-173
  • Peer Reviewed
• [Journal Article] オートプシー・イメージング（Ai）実施のケーススタディ 救急医学の立場から (2012)
  • Author(s): 大嶋清宏
  • Journal Title: INNERVISION Volume: 27 Pages: 22-23
• [Journal Article] Survival after 385 min of cardiopulmonary resuscitation with extracorporeal membrane oxygenation and rewarming with haemodialysis for hypothermic cardiac arrest (2011)
  • Author(s): Hagiwara S, Yamada T, Furukawa K, Ishihara K, Nakamura T, Ohyama Y, Tamura J, Oshima K
  • Journal Title: Resuscitation Volume: Vol.82, No.6 Issue: 6 Pages: 790-791
  • DOI: 10.1016/j.resuscitation.2010.11.032
  • Peer Reviewed
• [Journal Article] The effect of nicorandil on small intestinal ischemia-reperfusion injury in a canine model (2011)
  • Author(s): Suto Y, Oshima K, et al.
  • Journal Title: Digestive Diseases and Science Volume: Vol.56 Issue: 8 Pages: 2276-2282
  • DOI: 10.1007/s10620-011-1623-0
  • Peer Reviewed
• [Journal Article] The effect of nicorandil on small intestinal ischemia-reperfusion injury in a canine model (2011)
  • Author(s): Suto Y, Oshima K, et al.
  • Journal Title: Digestive Disease and Science Volume: (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Evaluation of prognosis in patients with respiratory failure requiring venovenous extracorporeal membrane oxygenation (ECMO) (2010)
  • Author(s): Oshima K, et al
  • Journal Title: Annals of Thoracic and Cardiovascular Surgery Volume: 16 Pages: 156-162
  • Peer Reviewed
• [Journal Article] Postoperative cardiac troponin (cTnI) level and its prognostic value for patients undergoing mitral valve surgery (2010)
  • Author(s): Oshima K, et al
  • Journal Title: International Heart Journal Volume: 51 Pages: 166-169
  • Peer Reviewed
• [Journal Article] Usefulness of serum fibrin degradation products and D-dimer levels as biomarkers to predict return of spontaneous circulation in patients with cardiopulmonary arrest on arrival : comparison with acid-base balance
  • Author(s): Hagiwara S, Murata M, Kaneko M, Aoki M, Kanbe M, Ohyama Y, Tamura J, Oshima K
  • Journal Title: Acute Medicine & Surgery Volume: (in press)
  • Peer Reviewed
• [Journal Article] The significance of albumin corrected anion gap in patients with cardiopulmonary arrest
  • Author(s): Hagiwara S, Oshima K, et al.
  • Journal Title: Annals of Thoracic and Cardiovascular Surgery Volume: (印刷中)
  • NAID: 130002583824
  • Peer Reviewed
• [Presentation] The influence of the ECG pattern in patients treated with ECPR (SOS-KANTO 2012 study interim report) (2014)
  • Author(s): Kaneko K, Hagiwara S, Oshima K, Ogasawara T, Tahara Y, Nagao K, Yaguchi A, Morimura N
  • Organizer: 43rd Society of Critical Care Medicine
  • Place of Presentation: San Francisco
  • Year and Date: 2014-01-10
• [Presentation] The influence of the ECG pattern in Patients Treated with ECPR (SOS-KANTO 2012 Study Interim Report) (2014)
  • Author(s): Kaneko M, Hagiwara S, Oshima K, Ogasawara T, Tahara Y, Nagao K, Yaguchi A, Morimura N.
  • Organizer: 43rd Critical Care Congress
  • Place of Presentation: San Francisco, CA, USA
• [Presentation] Fulminant myocarditis requiring percutaneous cardiopulmonary support system (PCPS) for the maintenance of hemodynamics (2013)
  • Author(s): Oshima K, Hagiwara S, Murata M, Aoki M, Kaneko M, Furukawa K, Nakamura T, Kunimoto F
  • Organizer: The 7^<th> Asian Conference on Emergency Medicine
  • Place of Presentation: Tokyo
  • Year and Date: 2013-10-25
• [Presentation] CPAOAのROSC予測因子の検討 (2013)
  • Author(s): 萩原周一、金子稔、青木誠、村田将人、神戸将彦、古川和美、中村卓郎、大山良雄、田村遵一、大嶋清宏
  • Organizer: 第41回日本救急医学会総会
  • Place of Presentation: 東京
  • Year and Date: 2013-10-22
• [Presentation] Fulminant myocarditis requiring percutaneous cardiopulmonary support system (PCPS) for the maintenance of hemodynamics (2013)
  • Author(s): Oshima K, Hagiwara S, Murata M, Aoki M, Kaneko M, Furukawa K, Nakamura T, Kunimoto F.
  • Organizer: The 7th Asian Conference on Emergency Medicine
  • Place of Presentation: Tokyo, Japan
• [Presentation] CPAOAのROSC予測因子の検討 (2013)
  • Author(s): 萩原周一、金子稔、青木誠、村田将人、神戸将彦、古川和美、中村卓郎、大山良雄、田村遵一、大嶋清宏
  • Organizer: 第41回ニホン救急医学会総会・学術集会
  • Place of Presentation: 東京
• [Presentation] 補助循環を用いた心肺蘇生 (2011)
  • Author(s): 大嶋清宏
  • Organizer: 第58回北関東医学会総会
  • Place of Presentation: 前橋
  • Year and Date: 2011-09-30
• [Presentation] 集中治療室入室症例におけるアポリポ蛋白CI(ApoCI)測定の意義 (2011)
  • Author(s): 大嶋清宏, 他
  • Organizer: 第38回日本集中治療医学会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-02-24
• [Book] 救急・集中治療ガイドライン2014-’15（担当：蘇生後の全身管理の指針） (2014)
  • Author(s): 大嶋清宏(岡元和文 編集・企画、分担執筆）
  • Total Pages: 3
  • Publisher: 総合医学社
• [Book] 緊急処置・蘇生・手技10.蘇生後の全身管理の指針, (救急・集中治療最新ガイドライン2012-'13 (2012)
  • Author(s): 大嶋清宏, (岡元和文編著)
  • Publisher: 総合医学社
• [Book] 蘇生後の全身管理の指針(救急・集中治療最新ガイドライン2012-13) (2012)
  • Author(s): 大嶋清宏(岡元和文編著)
  • Total Pages: 3
  • Publisher: 総合医学社
• [Remarks]
  • URL: http://emergency.dept.med.gunma-u.ac.jp/