| Project/Area Number |
22592010
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Emergency medicine
|
|---|
| Research Institution | Tokyo Medical and Dental University |
|---|
Principal Investigator |
MITAKA Chieko 東京医科歯科大学, 医歯(薬)学総合研究科, 准教授 (20126254)
|
|---|
| Project Period (FY) |
2010-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
|
|---|
| Keywords | 急性腎傷害 / 心房性ナトリウム利尿ペプチド / サイトカイン / 炎症 / 虚血再灌流傷害 / 造影剤 / 腎虚血•再灌流 / 造影剤腎症 / 虚血・再灌流傷害 / 多臓器障害症候群 / 抗炎症反応 / 虚血・再灌流障害 / 多臓器不全症候群 |
|---|
| Outline of Final Research Achievements |
We investigated whether atrial natriuretic peptide (ANP) attenuates renal ischemia-reperfusion injury (IRI)-induced acute kidney injury (AKI) or contrast-induced AKI. ANP prevented renal IRI-induced metabolic acidosis, pulmonary edema, increased plasma concentrations of lactate, creatinine and potassium in rats. In addition, ANP attenuated renal IRI-induced increases in plasma concentrations of IL-1beta and IL-6 as well as elevation of TNF-alpha, IL-1beta, IL-6 mRNA and TNF-alpha, IL-6, NF-kappaB protein expressions in kidney and lung. These findings suggest that ANP prevents kidney-lung cross talk by inhibiting inflammatory cytokines in rat renal IRI model. Furthermore, pretreatment of ANP attenuated contrast-induced AKI in rats.
|
