Cardioprotective effect of intravascular mild hypothermia against ischemia/reperfusion injury in rat isolated heart model
| Project/Area Number |
22592012
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
浦岡 雅博 浜松医科大学, 医学部付属病院, 助教 (30402332)
余 樹春 浜松医科大学, 医学部, リサーチアシスタント (00464115)
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| Co-Investigator(Renkei-kenkyūsha) |
YU Shuchun 浜松医科大学, 医学部, RA (00464115)
URAOKA Masahiro 浜松医科大学, 医学部付属病院, 助教 (30402332)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 救急蘇生学 / 虚血再灌流障害 / 心筋保護 / 低体温 / ERK / 心肺蘇生 / infarct size / viability / ischemia/reperfusion injury / reactive oxygen species (ROS) / cooling / nitric oxide (NO) / Phosphoinositide 3-kinase (PI3K) / reactive oxygen species |
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| Research Abstract |
A cardioprotective effect was present when hypothermia at 34 ℃ was induced during ischemia, and this effect still occurred when induction of hypothermia was early after reperfusion. Futhermore, the cardioprotective effect of hypothermia, was not observed when 10 min of 15 mmHg low-reperfusion immediately after ischemia was added to reperfusion period, but did occur when 10 min of 40 mmHg low-reperfusion immediately after ischemia was added. The phosphoinositide 3'kinase(PI3K)/nitric oxide (NO) pathway, and extracellular signal-regulated kinase(ERK) pathway were involved in the mechanism underlying the effect of hypothermia.
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Report
(4 results)
Research Products
(31 results)
