| Project/Area Number |
22592016
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAWAKITA Kenya 香川大学, 医学部附属病院, 講師 (10505803)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 心停止後症候群 / 重症頭部外傷 / マイクロダイアリシス / glycerol / glutamate / glucose / lactate/pyruvate 比 / Targeted temperature management / 神経集中治療 / 低体温療法 / 急性重症脳障害 / 常温療法 / 重症脳障害 / 嫌気性代謝 |
|---|
| Research Abstract |
This study evaluates the neurochemical changes in patients with traumatic brain injury (TBI) or post cardiac arrest syndrome (PCAS) using brain microdialysis. In TBI, large fluctuation of lactate/pyruvate ratio indicating poor outcome may related to cortical spreading depression. Lower cerebral perfusion pressure (CPP) under 60 mmHg relates increase of MD glycerol and decrease of MD glucose in TBI. In CPA patients, MD glycerol rose immediately and transiently after every intravenous glycerol (osmotic diuretic) administration, especially in poor outcome case. Lower CPP under 60 mmHg relates increase of MD glutamate in CPA. Plasma lactate and glucose relates MD lactate and MD glucose, respectively in CPA. Intracerebral MD parameter values must be analyzed with systemic parameters and the location of MD probe (the severity of the brain damage).
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