Preventive measure development for complications from Therapeutic Hypothermia.

• Project/Area Number: 22592017
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Ehime University
• Principal Investigator: AIBIKI Mayuki 愛媛大学, 大学院・医学系研究科, 教授 (70148162)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 低体温療法 / 心停止後症候群 / 頭部外傷 / 好中球機能 / 肺合併症 / 急性肺障害

Research Abstract

We have found a tendency of lowering pulmonary involvements in patients undergoing hypothermia treated with daily dexamethasone (DX) administration of 5 mg for 7 days as compared to those in historical controls undergoing normothermia without DX treatment. ThisDX effect may be mediated through neutrophil depressions, which was revealed by experiments of evaluating the effects of DX on human neutrophils in vitro and in vivo.

Research Products

• [Journal Article] Sepsis-induced cardiac dysfunction-病態から診断 (2012)
  • Author(s): 相引眞幸, 馬越健介、菊池聡他
  • Journal Title: 治療まで- 救急・集中治療 Volume: 24巻 Pages: 9-10
• [Journal Article] Good neurological recovery of a post-cardiac arrest patient with very low bispectral index values and high suppression ratios after resumption of spontaneous circulation (2012)
  • Author(s): M. Aibiki, S. Kikuchi, K. Umakoshi, et al.
  • Journal Title: Resuscitation Volume: 83 Issue: 3 Pages: 1399-1399
  • DOI: 10.1016/j.resuscitation.2011.09.033
  • Peer Reviewed
• [Journal Article] Sepsis-induced cardiac dysfunction-病態から診断、治療まで- (2012)
  • Author(s): 相引眞幸、馬越健介、菊池聡
  • Journal Title: 救急・集中治療 Volume: 24 Pages: 9-10
• [Journal Article] 心拍再開後の循環管理-Early Goal-directed Therapy (EGDT)- 心肺蘇生術ガイドライン2010に準拠して (2012)
  • Author(s): 相引眞幸、馬越健介、菊池聡、他
  • Journal Title: 蘇生 Volume: 31 Pages: 79-80
  • Peer Reviewed
• [Journal Article] カリウム補正の指標 (2012)
  • Author(s): 相引眞幸
  • Journal Title: 救急医学 Volume: 36 Pages: 1297-1300
• [Journal Article] JRC Resuscitation Guidelines 2010 -ALS Part of Post-arrest care- (English Version) (2012)
  • Author(s): Mayuki Aibiki, et al
  • Journal Title: ILCOR Homepage (Uploaded) Volume: -
  • Peer Reviewed
• [Journal Article] 日本版敗血症診療ガイドラインー分担、敗血症性DICー (2012)
  • Author(s): 相引眞幸（分担）
  • Journal Title: 日本集中治療医学会 Volume: -
  • Peer Reviewed
• [Journal Article] 日本版敗血症診療ガイドラインを読み解く (2012)
  • Author(s): 相引眞幸
  • Journal Title: ICUとCCU Volume: 36 Pages: 1007-1011
• [Journal Article] DICを合併した急性重症病態におけるAT製剤使用の工夫 (2011)
  • Author(s): 相引眞幸
  • Journal Title: 侵襲と免疫 Volume: 20 Pages: 34-36
• [Journal Article] Good neurological recovery of a post-cardiac arrest patient with very low bispectral index values and high suppression ratios after resumption of spontaneous circulation (2011)
  • Author(s): M.Aibiki, S.Kikuchi, K.Umakoshi, S.Ohtsubo, M.Ohshita, H.Matsumoto, T.Nishiyama
  • Journal Title: Resuscitation Volume: (Ahead of Print) Issue: 8 Pages: 1399-1399
  • DOI: 10.1007/s00134-011-2281-6
  • Peer Reviewed
• [Journal Article] 低体温療法は効くのか?二つの大規模RCTからの教訓 (2010)
  • Author(s): 相引眞幸、馬越健介、菊池聡, 他
  • Journal Title: 日本蘇生学会雑誌 Volume: 29 Pages: 6-12
  • NAID: 130004561603
  • Peer Reviewed
• [Journal Article] 心停止後症候群(PCAS)という病態-自己心拍再開後状態の新たなとらえ方- (2010)
  • Author(s): 相引眞幸
  • Journal Title: 救急医療ジャーナル Volume: 18 Pages: 6-6
• [Journal Article] Post Cardiac Arrest Syndrome(PCAS:心停止後症候群)に関するILCOR Consensus Statement (2010)
  • Author(s): 相引眞幸
  • Journal Title: ICUとCCU Volume: 34 Pages: 669-672
• [Journal Article] 意識障害を伴う心停止後症候群の神経学的予後判定におけるBispectral Index(BIS)の有用性 (2010)
  • Author(s): 相引眞幸、菊池聡、馬越健介, 他
  • Journal Title: ICUとCCU Volume: 34 Pages: 713-716
• [Journal Article] Post-cardiac arrest syndrome : epidemiology, pathophysiology, treatment, and prognostication : a scientific statement from the International Liaison Committee on Resuscitation ; the American Heart Association Emergency Cardiovascular Care Committee ; the Council on Cardiovascular Surgery and Anesthesia ; the Council on Cardiopulmonary, Perioperative, and Critical Care ; the Council on Clinical Cardiology ; the Council on Stroke (Part II). (2010)
  • Author(s): Nolan JP, Neumar RW, Adrie C, Aibiki M, et al
  • Journal Title: Int Emerg Nurs. Volume: 18 Pages: 8-28
  • Peer Reviewed
• [Presentation] Cooling Methods for Inducing Therapeutic Hypothermia in Patients with Post-Cardiac Arrest Syndrome. (2012)
  • Author(s): Mayuki Aibiki
  • Organizer: 1^<st> Pan-Pacific Emergency Medicine Congress. 特別講演
  • Place of Presentation: ソウル、大韓民国
  • Year and Date: 2012-10-25
• [Presentation] 心停止後症候群における神経蘇生を意識した集学的治療 (2012)
  • Author(s): 相引眞幸
  • Organizer: 第15回臨床救急医学会, シンポジュウム
  • Place of Presentation: 熊本
  • Year and Date: 2012-06-16
• [Presentation] JRC心肺蘇生術ガイドライン2010-心拍再開後の集中治療- (2011)
  • Author(s): 相引眞幸、大坪沙織、馬越健介、菊池聡、大下宗亮、松本紘典、西山隆
  • Organizer: 第30回日本蘇生学会
  • Place of Presentation: 福島市
  • Year and Date: 2011-11-18
• [Presentation] 敗血症性DICとトロンボモジュリン (2011)
  • Author(s): 相引眞幸
  • Organizer: 第28回日本集中治療医学会-中国四国地方会
  • Place of Presentation: 米子市
  • Year and Date: 2011-09-19
• [Presentation] Surface Cooling for inducing Therapeutic Hypothermia in Post-Cardiac Arrest Syndrome Patients (2011)
  • Author(s): Aibiki M, Kikuchi S, Umakoshi K, Ohtsubo S, Ohshita M, Matsumoto H, Nishiyama T
  • Organizer: The 4th International Hypothermia Symposium
  • Place of Presentation: Tokyo
  • Year and Date: 2011-09-16
• [Presentation] SERIAL CHANGES IN BISPECTRAL INDEX FROM SOON AFTER ROSCIN POST-CARDIAC ARREST SYNDROME PATINETS (2010)
  • Author(s): M.Aibiki, S.Kikuchi, K.Umakoshi, M.Ohshita, H.Matsumoto, S.Ohtsubo, T.Nishiyama
  • Organizer: Resuscitation Science Symposium
  • Place of Presentation: Chicago, IL, USA
  • Year and Date: 2010-11-13
• [Presentation] 低体温療法中の使用薬物-その薬理・生理学的検討- (2010)
  • Author(s): 相引眞幸
  • Organizer: 第13回 日本脳低温療法学会
  • Place of Presentation: 大阪
  • Year and Date: 2010-07-02
• [Presentation] 心停止後症候群について (2010)
  • Author(s): 相引眞幸
  • Organizer: 第23回脳死・脳蘇生学会
  • Place of Presentation: 東京
  • Year and Date: 2010-06-19
• [Presentation] Neurological Outcome for Unconscious Post-Cardiac Arrest Sydrome Patients can be Predicted by Bispectral Index (2010)
  • Author(s): M.Aibiki, S.Kikuchi, K.Umakoshi, M.Ohshita, H.Matsumoto, S.Ohtsubo, T.Nishiyama
  • Organizer: 33rd Annual Conference on Shock
  • Place of Presentation: Portland, Oregon, USA
  • Year and Date: 2010-06-12
• [Presentation] 心停止後症候群 (2010)
  • Author(s): 相引眞幸
  • Organizer: 第57回 日本麻酔科学会
  • Place of Presentation: 福岡
  • Year and Date: 2010-06-03
• [Presentation] 心停止後症候群(Post-Cardiac Arrest Syndrome : PCAS)に対する治療戦略 (2010)
  • Author(s): 相引眞幸
  • Organizer: 脳神経外科救急医学会
  • Place of Presentation: 東京
  • Year and Date: 2010-02-26
• [Presentation] 意識障害を伴う心停止後症候群の神経学的予後判定におけるBispectral Index(BIS)の有用性 (2010)
  • Author(s): 相引眞幸
  • Organizer: 第37回日本集中治療医学会学術集会
  • Place of Presentation: 広島
  • Year and Date: 2010-02-03
• [Presentation] 心停止後症候群における神経蘇生を意識した集学的治療
  • Author(s): 相引眞幸
  • Organizer: 第15回臨床救急医学会、シンポジュウム
  • Place of Presentation: 熊本
  • Invited
• [Presentation] Cooling Methods for Inducing Therapeutic Hypothermia in Patients withPost-Cardiac Arrest Syndrome
  • Author(s): Mayuki Aibiki
  • Organizer: 1st Pan-Pacific Emergency Medicine Congress
  • Place of Presentation: 大韓民国、ソウル
  • Invited
• [Presentation] 救急医療体制の現況と問題点
  • Author(s): 相引眞幸
  • Organizer: 第53回日本放射線技術学会 中国・四国部会学術大会 基調講演
  • Place of Presentation: 松山
  • Invited
• [Presentation] 急性病態における薬物動態
  • Author(s): 相引眞幸
  • Organizer: 第50回日本薬学・薬剤師学会 教育セミナー
  • Place of Presentation: 松江市
  • Invited
• [Presentation] 低体温療法中の各種モニタリング
  • Author(s): 相引眞幸、大下宗亮、大坪里織、他
  • Organizer: 第31回日本蘇生学会、シンポジウム
  • Place of Presentation: 大津市
  • Invited
• [Book] 救急蘇生法の指針(医療従事者用) (2012)
  • Author(s): 相引眞幸(分担執筆者)
  • Publisher: へるす出版
• [Book] 救急蘇生法の指針（医療従事者用） (2012)
  • Author(s): 相引眞幸
  • Publisher: へるす出版
• [Book] 心肺蘇生術ガイドラインーILGOR(ERC),RCA(JRC),AHAのガイドライン2010-2011救急診療指針、改訂第4版(日本救急医学会編) (2011)
  • Author(s): 相引眞幸, 他
  • Publisher: へるす出版
• [Book] JRCガイドライン2010-成人の2次救命処置-心拍再開後の集中治療-JRC心肺蘇生術ガイドライン2010 (2011)
  • Author(s): 相引眞幸, 他
  • Publisher: へるす出版
• [Book] Best of the Best Oral Abstract Presentations Resuscitation Sience Symposium (ReSS) Report 2010-AHA Pre-symposium- (2011)
  • Author(s): Mayuki Aibiki, et al
  • Publisher: Kyowa Kikaku
• [Book] Resuscitation Science Symposium (ReSS) Report (2010)
  • Author(s): 相引眞幸
  • Total Pages: 82
  • Publisher: Luncheon and Presentation of the 2009 Award for Lifetime Achievement in Trauma Ressuscitation Science