Assessment of brain damage after carbon monoxide poisoning using diffusion tensor imaging

• Project/Area Number: 22592020
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Iwate Medical University
• Principal Investigator: BEPPU Takaaki 岩手医科大学, 医学部, 准教授 (70275543)
• Co-Investigator(Kenkyū-buntansha): FUJIWARA Shunrou 岩手医科大学, 医学部, 助教 (60405842)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: CO中毒 / 大脳白質障害 / 拡散テンソル画像 / MRS / 一酸化炭素中毒 / MRI / 脱髄 / magnetic resonance spectroscopy / myelin basic protein

Research Abstract

The aim of this study is whether neuroimaging techniques such as diffusion tensor imaging (DTI) and magnetic resonance spectroscopy (MRS) are able to show quantitatively brain damage after carbon monoxide poisoning. We clarified that DTI and MRS demonstrate objectively and quantitatively pathological changes of the cerebral white matter after carbon monoxide poisoning, and also predict afterward prognoses in patients.

Research Products

• [Journal Article] 一酸化炭素中毒による脳損傷をコンベンショナルMRIはどこまで評価できるか (2013)
  • Author(s): 別府高明
  • Journal Title: 日本高気圧環境・潜水医学会雑誌 Volume: 48（1） Pages: 1-9
  • Peer Reviewed
• [Journal Article] Two patients with delayed neuropsychiatric sequelae caused by exposure to carbon monoxide under the same conditions. (2012)
  • Author(s): Kudo K, Sanjo K, Koizumi N, Koeda A, Otsuka K, Beppu T, Endo S, Sakai A.
  • Journal Title: Prim Care Companion CNS Disord. Volume: 14(3)
  • DOI: 10.4088/pcc.11l01316
  • Peer Reviewed
• [Journal Article] Fractional anisotropy in the centrum semiovale as a quantitative indicator of cerebral white matter damage in the subacute phase in patients with carbon monoxide poisoning: correlation with concentration of myelin basic protein in cerebrospinal fluid. (2012)
  • Author(s): Beppu T, Fujiwara S, Nishimoto H, KoedaA, NarumiS, Mori K, Ogasawara K, SasakiM:
  • Journal Title: J Neurol Volume: 259(8) Issue: 8 Pages: 1698-705
  • DOI: 10.1007/s00415-011-6402-5
  • Peer Reviewed
• [Journal Article] Detecting damaged regions of cerebral white matter in the subacute phase after carbon monoxide poisoning using voxel-based analysis with diffusion tensor imaging. (2012)
  • Author(s): Fujiwara S, Beppu T, Nishimoto H, Sanjo K, Koeda A, Mori K, Kudo K, Sasaki S, OgasawaraK:
  • Journal Title: Neuroradiology Volume: 54 Issue: 7 Pages: 681-689
  • DOI: 10.1007/s00234-011-0958-8
  • Peer Reviewed
• [Journal Article] 1H-magnetic resonance spectroscopy indicates damage to cerebral white matter in the subacute phase after CO poisoning. (2011)
  • Author(s): Beppu T, Nishimoto H, Fujiwara S , Kudo K, Sanjo K, Narumi S, Oikawa H, Onodera M, Ogasawara K, Sasaki M
  • Journal Title: J Neurol Neurosurg Psychiatry Volume: 82(8) Issue: 8 Pages: 869-75
  • DOI: 10.1136/jnnp.2010.222422
  • Peer Reviewed
• [Journal Article] 拡散テンソル画像を用いたCO中毒後大脳白質障害の評価日本高気圧環境・ (2011)
  • Author(s): 別府高明、西本英明、藤原俊朗、小笠原邦昭、鎌田 桂
  • Journal Title: 潜水医学会雑誌 Volume: 45 Pages: 208-208
  • Peer Reviewed
• [Journal Article] Prediction of malignancy grading using computed tomography perfusion imaging in nonenhancing supratentorial gliomas (2011)
  • Author(s): Beppu T, Sasaki M, Kudo K, Kurose A, Takeda M, et al
  • Journal Title: J Neurooncol Volume: 103 Issue: 3 Pages: 619-627
  • DOI: 10.1007/s11060-010-0433-0
  • Peer Reviewed
• [Journal Article] Assessment of damage to cerebral white matter fiber in the subacute phase after carbon monoxide poisoning using fractional anisotropy in diffusion tensor imaging (2010)
  • Author(s): Beppu T, NishimotoH, IshigakiD, FujiwaraS, YoshidaY, OikawaH, KamadaK, SasakiM, OgasawaraK:
  • Journal Title: Neuroradiology Volume: 52 (8) Issue: 8 Pages: 735-743
  • DOI: 10.1007/s00234-009-0649-x
  • Peer Reviewed
• [Journal Article] 急性一酸化炭素(CO)中毒におけるCOガスの暴露時間と頭部CT/MRI異常所見の関連性 (2010)
  • Author(s): 小野寺 誠、藤野靖久、井上義博、菊池哲、及川博隆、別府高明、遠藤重厚
  • Journal Title: 日本救急医学会雑誌 Volume: 21 Pages: 951-955
  • NAID: 10029086560
  • Peer Reviewed
• [Journal Article] Assessment of damage to cerebral white matter fiber in the subacute phase after carbon monoxide poisoning using fractional anisotropy in diffusion tensor imaging. (2010)
  • Author(s): Beppu T, Nishimoto H, Ishigaki D, Fujiwara S, et al.
  • Journal Title: Neuroradiology Volume: 52 Pages: 735-743
  • Peer Reviewed
• [Journal Article] The role of MR imaging in assessing brain damage from carbon monoxide poisoning: a review of the literature.
  • Author(s): Beppu T
  • Journal Title: AJNR Am J Neuroradiol Volume: (in press)
  • Peer Reviewed
• [Journal Article] ^1H-magnetic resonance spectroscopy indicates damage to cerebral white matter in the subacute phase after CO poisoning.
  • Author(s): Beppu T, Nishimoto H, Fujiwara S, et al.
  • Journal Title: Journal of Neurology Neurosurgery & Psychiatry Volume: (In press)
  • Peer Reviewed
• [Journal Article] Prediction of malignancy grading using computed tomography perfusion imaging in nonenhancing supratentorial gliomas.
  • Author(s): Beppu T, Sasaki M, Kudo K, et al.
  • Journal Title: Journal of Neurooncology Volume: (In press)
  • Peer Reviewed
• [Presentation] CO中毒に対するエダラボンによる抗酸化作用の臨床的評価 (2012)
  • Author(s): 別府高明
  • Organizer: 第47回日本高気圧環境・潜水医学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2012-11-16
• [Presentation] 悪性グリオーマにおける18F-FRP170 PETによる腫瘍内低酸素細胞検出ー酸素電極による腫瘍内酸素分圧との相関ー (2012)
  • Author(s): 別府高明
  • Organizer: 18回NMCC共同利用研究成果発表会
  • Place of Presentation: 盛岡
• [Presentation] Assessment of intratumoral vasculature using computed tomography perfusion imaging in supratentorial nonenhancing gliomas. (2012)
  • Author(s): Takaaki Beppu
  • Organizer: The Third Russian-Japanese Neurosurgical Symposium
  • Place of Presentation: ロシア
• [Presentation] 悪性グリオーマにおける18F-FRP170 PETによる腫瘍内低酸素細胞検出ー酸素電極による腫瘍内酸素分圧との相関ー (2012)
  • Author(s): 別府高明
  • Organizer: 第72回日本脳神経外科学会総会
  • Place of Presentation: 大阪
• [Presentation] 悪性グリオーマにおける18F-FRP170 PETによる腫瘍内低酸素細胞検出ー酸素電極による腫瘍内酸素分圧との相関ー. (2012)
  • Author(s): 別府高明
  • Organizer: 第30回日本脳神経外科学会総会
  • Place of Presentation: 広島
• [Presentation] 拡散テンソル画像を用いたCO中毒後大脳白質障害の評価 (2010)
  • Author(s): 別府高明、他
  • Organizer: 第45回日本高気圧環境・潜水医学会学術総会岡山
  • Place of Presentation: 岡山
  • Year and Date: 2010-11-26
• [Presentation] 拡散テンソル画像を用いたCO中毒後大脳白質障害の評価 (2010)
  • Author(s): 別府高明, 他
  • Organizer: 第45回日本高気圧環境・潜水医学会学術総会
  • Place of Presentation: 岡山
  • Year and Date: 2010-11-26
• [Presentation] 一酸化炭素中毒による大脳白質障害の神経画像解析 -治療戦略とHBO2有用性の実証のために- (2010)
  • Author(s): 別府高明
  • Organizer: 第2回日本高気圧環境・潜水医学会中国地方会
  • Place of Presentation: 山口
  • Year and Date: 2010-03-06