Analysis of extravascular lung water dynamics and exhaustive evaluation of pulmonary epithelial metabolites to establish a novel therapeutic approach for acute lung injury/ acute respiratory distress syndrome
| Project/Area Number |
22592023
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MASUNO Tomohiko 日本医科大学, 医学部, 助教 (00318528)
SATO Norio 日本医科大学, 医学部, 助教 (30409205)
MIYAUCHI Masato 日本医科大学, 医学部, 助教 (60312063)
HIRAKAWA Keiko 日本医科大学, 医学部, 助教 (30165162)
YOKOTA Hiroyuki 日本医科大学, 医学研究科, 教授 (60182698)
YAMANOUCHI Satoshi 東北大学, 大学院・医学系研究科, 教授 (00307638)
ENDO Tomoyuki 東北大学, 病院, 助教 (00400317)
KUDO Daisuke 東北大学, 病院, 助教 (30455844)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 急性肺損傷 / 急性呼吸窮迫症候群 / 肺血管外水分量 / 肺血管透過性 / 診断基準 / 急性肺水腫 |
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| Research Abstract |
Acute respiratory distress syndrome (ARDS) is characterized by acute pulmonary edema secondary to increased pulmonary vascular permeability. Although diagnostic criterion of ARDS reflecting the pathophysiological features of this condition has not been defined, we established a novel quantitative criterion of ARDS, using pulmonary vascular permeability combined with increased extravascular lung water content by a prospective, multi-institutional, observational study. We also demonstrated that the stages of ARDS by the Berlin definition predict increases in both the amount of extravascular lung water and the degree of pulmonary vascular permeability. The Berlin stages of disease progression are also associated with the severity of physiological derangements and damage-associated molecular patterns may be involved in the pathophysiology of ARDS.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] PiCCO Pulmonary Edema Study Group. Relationship between extravascular lung water and severity categories of acute respiratory distress syndrome by the Berlin definition2013
Author(s)
Kushimoto S, Endo T, Yamanouchi S, Sakamoto T, Ishikura H, Kitazawa Y, Taira Y, Okuchi K, Tagami T, Watanabe A, Yamaguchi J, Yoshikawa K, Sugita M, Kase Y, Kanemura T, Takahashi H, Kuroki Y, Izumino H, Rinka H, Seo R, Takatori M, Kaneko T, Nakamura T, Irahara T, Saito N
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] PiCCO Pulmonary Edema Study Group. The clinical usefulness of extravascular lung water and pulmonary vascular permeability index to diagnose and characterize pulmonary edema: a prospective multicenter study on the quantitative differential diagnostic definition for acute lung injury/acute respiratory distress syndrome2012
Author(s)
Kushimoto S, Taira Y, Kitazawa Y, Okuchi K, Sakamoto T, Ishikura H, Endo T, Yamanouchi S, Tagami T, Yamaguchi J, Yoshikawa K, Sugita M, Kase Y, Kanemura T, Takahashi H, Kuroki Y, Izumino H, Rinka H, Seo R, Takatori M, Kaneko T, Nakamura T, Irahara T, Saito N, Watanabe A
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Implementation of the Fifth Link of the Chain of Survival Concept for Out-of-Hospital Cardiac Arrest2012
Author(s)
Tagami T, Hirata K, Takeshige T, Matsui J, Takinami M, Satake M, Satake S, Yui T, Itabashi K, Sakata T, Tosa R, Kushimoto S, Yokota H, Hirama H.
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Journal Title
Circulation
Volume: 126
Issue: 5
Pages: 589-597
DOI
Related Report
Peer Reviewed
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[Journal Article] Validation of extravascular lung water measurement by single transpulmonary thermodilution: human autopsy study2010
Author(s)
Tagami T, Kushimoto S, Yamamoto Y, Atsumi T, Tosa R, Matsuda K, Oyama R, Kawaguchi T, Masuno T, Hirama H, Yokota H
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Journal Title
Critical Care
Volume: 14
Issue: 5
DOI
Related Report
Peer Reviewed
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