The role of gut derived arachidonic acid in post-hemorrhagic shock mesenteric lymph on the development of distant organ injury

Research Project

Project/Area Number	22592025
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Emergency medicine
Research Institution	Nippon Medical School
Principal Investigator	MASUNO Tomohiko 日本医科大学, 医学部, 講師 (00318528)
Co-Investigator(Kenkyū-buntansha)	SATO Norio 京都大学, 医学部, 講師 (30409205) KUSHIMOTO Shigeki 東北大学, 医学研究科, 教授 (50195434) YOKOTA Hiroyuki 日本医科大学, 医学研究科, 教授 (60182698)
Project Period (FY)	2010 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	腸管リンパ液 / 脂質メディエータ / 腸管虚血 / アラキドン酸 / 臓器障害 / 出血性ショック
Research Abstract	The purpose of this study is to determine the role of arachidonic acid in post-hemorrhagic shock mesenteric lymph (PSML) on the development of distant organ injury. We have shown that mesenteric ischemia generates phospholipase A2 protein in PSML, which induce neutrophil priming and acute lung injury in a two-event model. We have been investigating further mechanism of post-hemorrhagic shock mesenteric lymph inducedorgan injury including arachidonic acid.