The role of extracellular matrix degradation enzymes, MMP and ADAM in tumor micro environment (stem cell niche)

• Project/Area Number: 22592030
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Morphological basic dentistry
• Research Institution: National Center for Geriatrics and Gerontology (2011-2012); Tokyo Medical and Dental University (2010)
• Principal Investigator: NAKAMURA Hiroyuki 独立行政法人国立長寿医療研究センター, 再生歯科医療研究部, 副部長 (30542253)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: ADAM / MMP / TIMP3 / 癌幹細胞

Research Abstract

In oral tumor micro environment (stem cell niche), the role of extracellular matrix degradation enzymes, MMP and ADAM which is critical for tumor invasion and metastasis, is not clear. To address this question, we establish transgenic mice which overexpress MMP or ADAM specific inhibitor in niche cells specifically, and try to identify which protease is involved in regulation of oral tumor micro environment

Research Products

• [Journal Article] The anti-inflammatory effects of matrix metalloproteinase-3 on irreversible pulpitis of mature erupted teeth. (2012)
  • Author(s): Eba, H., Murasawa, Y., Iohara, K., Isogai, Z., Nakamura, H., Nakamura, H. and Nakashima, M.
  • Journal Title: PloS one Volume: 7
• [Journal Article] The anti-inflammatory effects of matrix metalloproteinase-3 on irreversible pulpitis of mature erupted teeth. (2012)
  • Author(s): Eba, H., Murasawa, Y., Iohara, K., Isogai, Z.,Nakamura, H., and Nakashima, M
  • Journal Title: PloS one Volume: 7 Issue: 12 Pages: e52523-e52523
  • DOI: 10.1371/journal.pone.0052523
  • Peer Reviewed
• [Journal Article] Microchimeric fetal cells are recruited to maternal kidney following injury and activate collagen type I transcription. (2011)
  • Author(s): Bou-Gharios, G., Amin, F., Hill, P., Nakamura, H., Maxwell, P., and Fisk, NM.
  • Journal Title: Cells Tissues Organs Volume: 193 Pages: 379-392
• [Journal Article] Microchimeric fetal cells are recruited to maternal kidney following injury and activate collagen type I transcription (2011)
  • Author(s): Bou-Gharios G., Amin F., Hill P., Nakamura H., Maxwell P., Fisk NM
  • Journal Title: Cells Tissues Organs Volume: 193 Issue: 6 Pages: 379-392
  • DOI: 10.1159/000321172
  • Peer Reviewed
• [Journal Article] Microchimeric fetal cells are recruited to maternal kidney following injury and activate collagen type 1 transcription. (2011)
  • Author(s): Hiroyuki Nakamura
  • Journal Title: Cells Tissues Organs Volume: In press
  • Peer Reviewed
• [Journal Article] Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis. (2010)
  • Author(s): Sonnylal, S., Shi-Wen, X., Leoni, P., Naff, K., Van Pelt, CS., Nakamura, H., Leask, A., Abraham, D., Bou-Gharios, G., and de Crombrugghe, B.
  • Journal Title: Arthritis Rheum Volume: 62 Pages: 1523-1532
• [Presentation] 歯の再生医療 (2013)
  • Author(s): 中村博幸
  • Organizer: 平成25年度九州歯科大同窓会北陸支部学術講演会
  • Place of Presentation: 福井
  • Year and Date: 2013-03-02
• [Presentation] 歯の再生医療 (2012)
  • Author(s): 中村博幸
  • Organizer: 平成24年度九州歯科大東京都同窓会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2012-10-13
• [Presentation] MMP-3の歯髄炎での抗炎症, 組織再生作用の検討 (2012)
  • Author(s): 中村博幸
  • Organizer: 第10回日本再生歯科医学会(シンポジウムI)
  • Place of Presentation: 神戸
  • Year and Date: 2012-09-01
• [Presentation] 歯科再生医療の背景と最先端事情 (2012)
  • Author(s): 中村博幸
  • Organizer: 第22回金沢歯科口腔外科懇話会
  • Place of Presentation: 金沢
  • Year and Date: 2012-02-25
• [Presentation] MMP-3 の歯髄炎での抗炎症, 組織再生作用の検討 (2012)
  • Author(s): 中村博幸
  • Organizer: 第10回日本再生歯科医学会（シンポジウムI）
  • Place of Presentation: 神戸
  • Invited
• [Presentation] 細胞外マトリックス分解最近の知見 (2011)
  • Author(s): 中村博幸
  • Organizer: 平成23年愛知医科大学分子医科学研究所フォーラム
  • Place of Presentation: 愛知
  • Year and Date: 2011-04-20
• [Presentation] 細胞外マトリックス分解最近の知見 (2010)
  • Author(s): 中村博幸
  • Organizer: 第17回プロテオグリカンフォーラム
  • Place of Presentation: 東京
  • Year and Date: 2010-02-27
• [Book] 炎症メディエーターメタロプロテアーゼ (2010)
  • Author(s): 中村博幸, 岡田保典
  • Publisher: 日本臨床
• [Book] メタロプロテアーゼ関節リウマチ(寛解を目指す治療の新時代)第2版 (2010)
  • Author(s): 中村博幸、岡田保典
  • Publisher: 日本臨床増刊