| Project/Area Number |
22592036
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
IKEGAME Mika 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (70282986)
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| Co-Investigator(Kenkyū-buntansha) |
KITAMURA Keiichiro 金沢大学, 保健学系, 准教授 (80283117)
TABUCHI Yoshiaki 富山大学, 生命科学先端研究センター, 准教授 (20322109)
河井 まりこ 岡山大学, 医歯(薬)学総合研究科, 助教 (40379839)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 骨形成・機械的刺激 / 局所因子 / サイトカイン / 骨縫合部組織 / Wnt / 骨形成 / 機械的刺激 / BMP / 骨芽細胞 / 網羅的遺伝子解析 / βカテニン |
|---|
| Research Abstract |
We can stimulate bone formation with tensile stress on a suture of mouse calvaria. Gene expressions of many factors, especially Wnt/beta-catenin family which are involved in bone-cell activity were examined during the stimulated bone formation. We could show the relative expression ratios of some factors at each time point of the experiment. Those results suggested which factors were more important at each stage of the stimulated bone formation.
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