• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The identification of cell surface antigen of oral streptococcus for development of vaccine for oral cancer

Research Project

Project/Area Number 22592046
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Morphological basic dentistry
Research InstitutionIwate Medical University

Principal Investigator

SASAKI Minoru  岩手医科大学, 歯学部, 准教授 (40187133)

Co-Investigator(Renkei-kenkyūsha) KIMURA Shigenobu  岩手医科大学, 歯学部, 教授 (10177917)
SHIMOYAMA Yu  岩手医科大学, 歯学部, 助教 (90453331)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
KeywordsStreptococcus anginosus / フィブロネクチン結合タンパク質 / 上皮細胞 / 付着因子 / S. anginosus / 口腔レンサ球菌 / 口腔癌 / ワクチン開発 / 粘膜上皮細胞 / 付着
Research Abstract

Streptococcus anginosus inhabits dental plaques, and its infection in oral mucosa could be closely related with some squamous cell carcinoma. In this study for the development of vaccine, the fibronectin binding protein gene of S. anginosus, designated fbp62 was cloned, and the pathogenic involvement of Fbp62 in S. anginosusinfection was investigated. The results indicated that the adhesive ability of an fbp62knockout mutan t (Dfbp62) of S. anginosus to mucosal epithelial cells diminished significantly, and that the Dfbp62-infected mice showed considerably lower mortality and abscess formation rates, compared to the wild type S. anginosus-infected mice. Thus, a novel fibronectin binding protein of S. anginosus, Fbp62, could be an effective vaccine candidate for the S. anginosus-related oral cancer.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (63 results)

All 2013 2012 2011 2010 Other

All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (38 results) Book (11 results) Remarks (1 results)

  • [Journal Article] Subcutaneous tissue reactions against nano-apatite collagen composites.2012

    • Author(s)
      Hatakeyama, W., Taira, M., Y., Kihara, H., Sasaki, M., Kimura, S., Kondo, H.
    • Journal Title

      Nano Biomedicine

      Volume: 4 Pages: 118-124

    • NAID

      130004679846

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Quantatative real -time RT -PCR analyses of DNA-damage-recovery-related gene expressions of mouse macrophage-like cell line RAW264 when exposed to IC50 nickel ions.2012

    • Author(s)
      Taira, M., Y., Kagiya, T., Sasaki, M., Kimura, S.
    • Journal Title

      Nano Biomedicine

      Volume: 3 Pages: 294-299

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Quantatative real-time RT-PCR analyses of DNA-damage-recovery-related gene expressions of mouse macrophage-like cell line RAW264 when exposed to IC50 nickel ions.2012

    • Author(s)
      Taira, M.
    • Journal Title

      Nano Biomedicine

      Volume: 3 Pages: 294-299

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proteome analyses of human macrophages exposed to low cytotoxic IC90 copper (2+) ions2011

    • Author(s)
      Taira, M., Shimoyama, Y ., Kagiya, T., Sasaki, M., Nezu, T., Harada, H. and Kimura, S.
    • Journal Title

      Dent. Mater. J.

      Volume: 30 Pages: 293-299

    • NAID

      10029136627

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative real-time RT-PCR analyses of DNA-damage-recovery-related gene expressions of mouse macrophage-like cell line RAW264 when exposed to IC 50 nickel ions.2011

    • Author(s)
      Taira, M., Kagiya, T., Sasaki, M. and Kimura, S
    • Journal Title

      Nano Biomed

      Volume: 3 Pages: 294-299

    • NAID

      130004555811

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative real-time RT-PCR analyses of DNA-damage-recovery-related gene expressions of mouse macrophage-like cell line RAW264 when exposed to IC_<50> nickel ions2011

    • Author(s)
      Taira, M.
    • Journal Title

      Nano Biomedicine

      Volume: 3 Pages: 294-299

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proteome analyses of human macrophages exposed to low cytotoxic IC90 copper (2+) ions2011

    • Author(s)
      Taira, M.
    • Journal Title

      Dent.Mater.J.

      Volume: 30 Pages: 293-299

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Microscopic observations and inflammatory cytokine productions of human macrophage phagocytising submicron titanium particles2010

    • Author(s)
      Taira, M., Kagiya, T., Harada, H., Sasaki, M., Kimura, S., Narushima, T., Nezu, T. and Araki, Y.
    • Journal Title

      J. Mater. Sci. Mater. Med.

      Volume: 21 Pages: 267-275

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between oral status and prevalence of periodontopathic bacteria on the tongues of elderly individuals2010

    • Author(s)
      Kishi, M., Ohara -Nemoto, Y., Takahashi, M., Kishi, K., Kimura, S. and Yonemitsu, M
    • Journal Title

      J. Med. Microbiol.

      Volume: 59 Pages: 1354-1359

    • NAID

      120006984948

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Amino acid residues modulating the activities of staphylococcal glutamyl endopeptidases2010

    • Author(s)
      Ono, T., Ohara-Nemoto, Y., Shimoyama, Y., Okawara, H., Kobayakawa, T., Baba, T. T., Kimura, S. and Nemoto, T. K.:
    • Journal Title

      Biol. Chem

      Volume: 391 Pages: 1221-1232

    • NAID

      120006984895

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Histological and TEMobservation of subcutaneous tissues exposed to particulate copper,nickel and titanium2010

    • Author(s)
      Saitoh, S., Sasaki, K., Nezu, T., Taira, M., Shimoyama, Y. , Sasaki, M., Kimura, S.and Ishizeki, K
    • Journal Title

      J. Oral Tissue Engin

      Volume: 8 Pages: 102-106

    • NAID

      130004941170

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Microscopic observations and inflammatory cytokine productions of human macrophage phagocytising submicron titanium particles.2010

    • Author(s)
      Taira, M., Kagiya, T., Harada, H., Sasaki, M., Kimura, S., Narushima, T., Nezu, T., Araki, Y.
    • Journal Title

      J.Mater.Sci.Mater.Med.

      Volume: 21 Pages: 267-275

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histological and TEM observation of subcutaneous tissues exposed to particulate copper, nickel and titanium.2010

    • Author(s)
      Saitoh, S., Sasaki, K., Nezu, T., Taira, M., Shimoyama, Y., Sasaki, M., Kimura, S., Ishizeki, K.
    • Journal Title

      J.Oral Tissue Engin.

      Volume: 8 Pages: 102-106

    • NAID

      130004941170

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] The aciduricity inStreptococcus anginosus2013

    • Author(s)
      Sasaki, M., Kodama, Y., Shimoyama, Y ., Kimura, S.:
    • Organizer
      91th Genera l Session & Exhibition of the International Association of Dental Research (IADR)
    • Place of Presentation
      Siattle, USA
    • Year and Date
      2013-03-21
    • Related Report
      2012 Final Research Report
  • [Presentation] Nested PCRを用いた小児口腔へのPorphyromonas gingivalis 線毛タイプ別感染実態の検討.2013

    • Author(s)
      下山 佑,木村美澄,佐々木実,根本優子,古玉芳豊,上戸幸美,田中光郎,木村重信
    • Organizer
      第86回日本細菌学会総会
    • Place of Presentation
      幕張
    • Year and Date
      2013-03-20
    • Related Report
      2012 Final Research Report
  • [Presentation] The aciduricity in Streptococcus anginosus.2013

    • Author(s)
      Sasaki, M.
    • Organizer
      91th General Session & Exhibition of the International Association of Dental Research
    • Place of Presentation
      Seattle, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Nested PCRを用いた小児口腔へのPorphyromonas gingivalis 線毛タイプ別感染実態の検討2013

    • Author(s)
      下山 佑
    • Organizer
      第86回日本細菌学会総会
    • Place of Presentation
      幕張,千葉
    • Related Report
      2012 Annual Research Report
  • [Presentation] Streptococcus anginosusの耐酸性に関わる酵素の役割2012

    • Author(s)
      佐々木実,古玉芳豊,下山 佑,木村重信
    • Organizer
      第54回歯科基礎医学会学術大会
    • Place of Presentation
      郡山
    • Year and Date
      2012-09-16
    • Related Report
      2012 Final Research Report
  • [Presentation] A Novel Fibronectin Binding Protein of Streptococcus intermedius.2012

    • Author(s)
      Sasaki, M., Kodama, Y., Shimoyama, Y., Kimura, S
    • Organizer
      90th General Session & Exhibition of the International Association of Dental Research (IADR)
    • Place of Presentation
      Iguacu Falls, Brazil
    • Year and Date
      2012-06-21
    • Related Report
      2012 Final Research Report
  • [Presentation] Streptococcus intermediusのフィブロネクチン結合タンパク質による上皮細胞付着機序2012

    • Author(s)
      古玉芳豊,佐々木 実,下山 佑,上戸幸美,木村重信
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎
    • Year and Date
      2012-03-27
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] Streptococcus anginosusの耐酸性に関わる酵素の役割2012

    • Author(s)
      佐々木実
    • Organizer
      第54回歯科基礎医学会学術大会
    • Place of Presentation
      郡山,福島
    • Related Report
      2012 Annual Research Report
  • [Presentation] A Novel Fibronectin Binding Protein of Streptococcus intermedius.2012

    • Author(s)
      Sasaki, M
    • Organizer
      90th General Session & Exhibition of the International Association of Dental Research
    • Place of Presentation
      Iguas Falls, Brzil
    • Related Report
      2012 Annual Research Report
  • [Presentation] Streptococcus anginosusのフィブロネクチン結合タンパク質のマウスにおける病原性の解析2011

    • Author(s)
      佐々木 実,古玉芳豊,下山 佑,木村重信
    • Organizer
      第53回歯科基礎医学会学術大会
    • Place of Presentation
      岐阜
    • Year and Date
      2011-10-01
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] The pathogenic involvement of the fibronectin binding protein, Fbp62, in Streptococcus anginosus infection.2011

    • Author(s)
      Sasaki, M., Kodama, Y., Shimoyama, Y ., Agato, S. and Kimura, S.
    • Organizer
      International Union of Microbiological Societies 2011 Congress (IUMS 2011)
    • Place of Presentation
      Sapporo, Japan
    • Year and Date
      2011-09-07
    • Related Report
      2012 Final Research Report
  • [Presentation] The pathogenic involvement of the fibronectin binding protein, Fbp62, in Streptococcus anginosus infection2011

    • Author(s)
      Sasaki, M.
    • Organizer
      International Union of Microbiological Societies 2011 Congress
    • Place of Presentation
      Sapporo
    • Year and Date
      2011-09-07
    • Related Report
      2011 Annual Research Report
  • [Presentation] Fbp62, fibronectin binding protein of Streptococcus anginosus involves the virulence in mouse infection2011

    • Author(s)
      Sasaki, M.
    • Organizer
      10th World Congress on Inflammation 2011
    • Place of Presentation
      Paris
    • Year and Date
      2011-06-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Fbp62, fibronectin binding protein of Streptococcus anginosus involves the virulence in mouse infection.2011

    • Author(s)
      Sasaki, M., Kodama, Y., Shimoyama, Y., Ishikawa, T. and Kimura, S.
    • Organizer
      10th World Congress on Inflammation 2011
    • Place of Presentation
      Paris, France
    • Year and Date
      2011-06-26
    • Related Report
      2012 Final Research Report
  • [Presentation] Auto-catalytic propeptide processing facilitates the final hetero-catalytic maturation of glutamyl endopeptidase GluV8.2011

    • Author(s)
      Ohara -Nemoto, Y., Rouf, S.M.A., Shimoyama, Y., Kimura, S. , Ono, T. and Nemoto, T.K.
    • Organizer
      111th General Meeting of the American Society for Microbiology.
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2011-05-24
    • Related Report
      2012 Final Research Report
  • [Presentation] Fibronectin binding activity of Streptococcus anginosus promotes the adherence to mucosal epithelial cells.2011

    • Author(s)
      Sasaki, M., Kodama, Y., Shimoyama, Y., Ishikawa, T. and Kimura, S.
    • Organizer
      4th International Symposium for Interface Oral Health Science in Sendai
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      2011-03-08
    • Related Report
      2012 Final Research Report
  • [Presentation] Rapid identification of Abiotrophia/Granulicatella species using by 16S rRNA based PCR and RFLP.2011

    • Author(s)
      Shimoyama, Y., Sasaki, M., Ohara-Nemoto, Y., Nemoto, T. K., Ishikawa, T. and Kimura, S
    • Organizer
      4th International Symposium for Interface Oral Health Science in Sendai
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      2011-03-08
    • Related Report
      2012 Final Research Report
  • [Presentation] Maternal transmission of mutans and other oral streptococcal species2011

    • Author(s)
      Otake -Asakawa, A., Harada-Oikawa, R., Ohara-Nemoto, Y., Tanaka, M. and Kimura, S.
    • Organizer
      4th International Symposium for Interface Oral Health Science in Sendai
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      2011-03-08
    • Related Report
      2012 Final Research Report
  • [Presentation] In vitro adherence of Candida albicans to acrylic resin with different surface status2011

    • Author(s)
      Nomura, T., Suzuki, T., Furuya, J., Shimoyama, Y., Sasaki, M. and Kimura, S.
    • Organizer
      4th International Symposium for Interface Oral Health Science in Sendai.
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      2011-03-08
    • Related Report
      2012 Final Research Report
  • [Presentation] Macrophage reaction against sub-micron titanium particles2011

    • Author(s)
      Taira, M., Sasaki, M. and Kimura, S.
    • Organizer
      4th International Symposium for Interface Oral Health Science in Sendai.
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      2011-03-08
    • Related Report
      2012 Final Research Report
  • [Presentation] Fibronectin binding activity of Streptococcus anginosus promotes the adherence to mucosal epithelial cells.2011

    • Author(s)
      Sasaki, M., Kodama, Y., Shimoyama, Y., Ishikawa, T., Kimura, S.
    • Organizer
      4th International Symposium for Interface Oral Health Science
    • Place of Presentation
      Sendai
    • Year and Date
      2011-03-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Rapid identification of Abiotrophia/Granulicatella species using by 16S rRNA based PCR and RFLP.2011

    • Author(s)
      Shimoyama, Y., Sasaki, M., Ohara-Nemoto, Y., Nemoto, T.K., Ishikawa, T., Kimura, S.
    • Organizer
      4th International Symposium for Interface Oral Health Science
    • Place of Presentation
      Sendai
    • Year and Date
      2011-03-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] In vitro adherence of Candida albicans to acrylic resin with different surface status.2011

    • Author(s)
      Nomura, T., Suzuki, T., Furuya, J., Shimoyama, Y., Sasaki, M., Kimura, S.
    • Organizer
      4th International Symposium for Interface Oral Health Science
    • Place of Presentation
      Sendai
    • Year and Date
      2011-03-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Macrophage reaction against sub-micron titanium particles.2011

    • Author(s)
      Taira, M., Sasaki, M., Kimura, S.
    • Organizer
      4th International Symposium for Interface Oral Health Science
    • Place of Presentation
      Sendai
    • Year and Date
      2011-03-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Nutritionally variant streptococciの新規迅速同定法の開発2010

    • Author(s)
      下山 佑,佐々木 実,石河太知,古玉芳豊,木 村 重 信
    • Organizer
      第36回岩手医科大学歯学会総会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-12-04
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] ストレプトアビジン付き磁性マイクロビーズを用いた単球の磁気回収に関する研究2010

    • Author(s)
      平 雅之,佐々木 実, 木村重信
    • Organizer
      第52回歯科基礎医学会学術大会総会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-22
    • Related Report
      2012 Final Research Report
  • [Presentation] Anginosus group streptococciのフィブロネクチン結合タンパク質の解析2010

    • Author(s)
      古玉芳豊,佐々木 実,下山 佑,石河太知,木村重信
    • Organizer
      第52回歯科基礎医学会学術大会総会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-22
    • Related Report
      2012 Final Research Report
  • [Presentation] Nutritionally variant streptococciの新規迅速同定法の開発2010

    • Author(s)
      下山 佑,佐々木 実,石河太知,根本優子,根 本 孝 幸 ,木 村 重 信
    • Organizer
      第52回歯科基礎医学会学術大会・総会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-22
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] ストレプトアビジン付き磁性マイクロビーズを用いた単球の磁気回収に関する研究2010

    • Author(s)
      平雅之, 佐々木実, 木村重信
    • Organizer
      第52回歯科基礎医学会学術大会・総会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] Anginosus group streptococciのフィブロネクチン結合タンパク質の解析2010

    • Author(s)
      古玉芳豊, 佐々木実, 下山佑, 石河太知, 木村重信
    • Organizer
      第52回歯科基礎医学会学術大会・総会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] Nutritionally variant streptococci の新規迅速同定法2010

    • Author(s)
      下山 佑,佐々木 実,石河太知,木村重信
    • Organizer
      第64回日本細菌学会 東北支部総会
    • Place of Presentation
      仙台
    • Year and Date
      2010-08-19
    • Related Report
      2012 Final Research Report
  • [Presentation] Nutritionally variant streptococciの新規迅速同定法2010

    • Author(s)
      下山佑, 佐々木実, 石河太知, 木村重信
    • Organizer
      第64回日本細菌学会 東北支部総会
    • Place of Presentation
      仙台
    • Year and Date
      2010-08-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] Structural chemistry of Staphylo coccus aureus glutamyl endopeptidase.2010

    • Author(s)
      Ohara -Nemoto, Y., Rouf, S.M.A., Shimoyama, Y., Kimura, S. and Nemoto, T.K.
    • Organizer
      88th General Session & Exhibition of the IADR
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2010-07-16
    • Related Report
      2012 Final Research Report
  • [Presentation] SLPI production from gingival epithelial cells against Porphyromonas gingivalis infection.2010

    • Author(s)
      Ishikawa, T., Ohara-Nemoto, Y., Shimoyama, Y., Sasaki, M., Kimura, S.
    • Organizer
      88th General Session & Exhibition of the IADR
    • Place of Presentation
      Barcelona (Spain)
    • Year and Date
      2010-07-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] SLPI production from gingival epithelial cells against Porphyromonas gingivalis infection.2010

    • Author(s)
      Ishikawa, T., Ohara-Nemoto, Y., Shimoyama, Y., Sasaki, M. and Kimura, S
    • Organizer
      88th General Session & Exhibition of the IADR.
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2010-07-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Maternal transmission of mutans and other oral streptococcal species.2010

    • Author(s)
      Otake -Asakawa, A., Kimura, S. , Asakawa, T. and Tanaka, M.
    • Organizer
      88th General Session & Exhibition of the IADR.
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2010-07-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Adhesion mechanism of Streptococcus anginosus to mucosal epithelial cells.2010

    • Author(s)
      Kodama, Y., Sasaki, M., Shimoyama, Y., Tajika, S. and Kimura, S.
    • Organizer
      20th European Congress of Clinical Microbiology and Infectious Diseases (20th ECCMID 2010)
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2010-04-13
    • Related Report
      2012 Final Research Report
  • [Presentation] Adhesion mechanism of Streptococcus anginosus to mucosal epithelial cells.2010

    • Author(s)
      Kodama, Y., Sasaki, M., Shimoyama, Y., Tajika, S., Kimura, S.
    • Organizer
      20th European Congress of Clinical Microbiology and Infectious Diseases
    • Place of Presentation
      Vienna (Austria)
    • Year and Date
      2010-04-13
    • Related Report
      2010 Annual Research Report
  • [Book] Pathogenesis and Treatment of Periodontitis2012

    • Author(s)
      Kimura, S., Ohara-Nemoto, Y., Shimoyama, Y., Ishikawa, T., and Sasaki, M.
    • Publisher
      In Periodontitis, InTech:Pathogenic factors of Porphyromonas gingivalis and the host difence mechanisms.
    • Related Report
      2012 Final Research Report
  • [Book] Fibronectin binding activity of Streptococcus anginosus promotes the adherence to mucosa l epithelial cells. In Interface Oral Health Science 20112012

    • Author(s)
      Sasaki, M., Kodama, Y., Shimoyama, Y. , Ishikawa, T. and Kimura, S
    • Publisher
      Springer Japan, Tokyo
    • Related Report
      2012 Final Research Report
  • [Book] Rapid identification of Abiotrophia/Gr anulicatella species using by 16S rRNA based PCR and RFLP In Interface Oral Health Science 20112012

    • Author(s)
      Shimoyama, Y., Sasaki, M. , Ohara -Nemoto, Y., Nemoto, T. K., Ishikawa, T. and Kimura, S.
    • Publisher
      Springer Japan, Tokyo
    • Related Report
      2012 Final Research Report
  • [Book] Mate rnal transmission of mutans and other oral streptococcal species. In Interface Oral Health Science 20112012

    • Author(s)
      Otake-Asakawa, A., Harada-Oikawa, R., Ohara-Nemoto, Y., Tanaka, M. and Kimura, S.
    • Publisher
      Springer Japan, Tokyo
    • Related Report
      2012 Final Research Report
  • [Book] In vitro adherence of Candida albicans to acrylic resin with different surface status. In Interface Oral Health Science 20112012

    • Author(s)
      Nomura, T., Suzuki, T., Furuya, J., Shimoyama, Y. , Sasaki, M. and Kimura, S.
    • Publisher
      Springer Japan, Tokyo
    • Related Report
      2012 Final Research Report
  • [Book] Macrophage reaction against sub-micron titanium particles.In Interface Oral Health Science 20112012

    • Author(s)
      Taira, M., Sasaki, M. and Kimura, S.
    • Publisher
      Springer Japan, Tokyo
    • Related Report
      2012 Final Research Report
  • [Book] Pathogenesis and Treatment of Periodontitis2012

    • Author(s)
      Kimura, S.
    • Total Pages
      200
    • Publisher
      InTech
    • Related Report
      2012 Annual Research Report
  • [Book] Interface Oral Health Science 20112012

    • Author(s)
      Sasaki, M.
    • Publisher
      Springer(in press)
    • Related Report
      2011 Annual Research Report
  • [Book] Interface Oral Health Science 20112012

    • Author(s)
      Shimoyama, Y.
    • Publisher
      Springer(in press)
    • Related Report
      2011 Annual Research Report
  • [Book] Interface Oral Health Science 20112012

    • Author(s)
      Taira, M.
    • Publisher
      Springer(in press)
    • Related Report
      2011 Annual Research Report
  • [Book] Interface Oral Health Science 20112012

    • Author(s)
      Nomura, T.
    • Publisher
      Springer(in press)
    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://hitech-d.iwate-med.ac.jp/micr/index.htm

    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi