| Project/Area Number |
22592046
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
|
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| Research Institution | Iwate Medical University |
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Principal Investigator |
SASAKI Minoru 岩手医科大学, 歯学部, 准教授 (40187133)
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| Co-Investigator(Renkei-kenkyūsha) |
KIMURA Shigenobu 岩手医科大学, 歯学部, 教授 (10177917)
SHIMOYAMA Yu 岩手医科大学, 歯学部, 助教 (90453331)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | Streptococcus anginosus / フィブロネクチン結合タンパク質 / 上皮細胞 / 付着因子 / S. anginosus / 口腔レンサ球菌 / 口腔癌 / ワクチン開発 / 粘膜上皮細胞 / 付着 |
|---|
| Research Abstract |
Streptococcus anginosus inhabits dental plaques, and its infection in oral mucosa could be closely related with some squamous cell carcinoma. In this study for the development of vaccine, the fibronectin binding protein gene of S. anginosus, designated fbp62 was cloned, and the pathogenic involvement of Fbp62 in S. anginosusinfection was investigated. The results indicated that the adhesive ability of an fbp62knockout mutan t (Dfbp62) of S. anginosus to mucosal epithelial cells diminished significantly, and that the Dfbp62-infected mice showed considerably lower mortality and abscess formation rates, compared to the wild type S. anginosus-infected mice. Thus, a novel fibronectin binding protein of S. anginosus, Fbp62, could be an effective vaccine candidate for the S. anginosus-related oral cancer.
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